Paramagnetic liposomes as MRI contrast agents: Influence of liposomal physicochemical properties on the in vitro relaxivity

Magnetic Resonance Imaging

Volumn 17, Issue 1, 1999, Pages 83-89

  Fossheim, Sigrid L ^a   Fahlvik, Anne Kjersti ^a   Klaveness, Jo ^a   Muller, Robert N ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF MONS   (Belgium)

Author keywords

Dipolar relaxation; Liposome composition; Liposome encapsulated GdHPDO3A; Liposome size; Susceptibility effects; Water exchange

Indexed keywords

GADOTERIDOL; LIPOSOME; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT;

ARTICLE; CONTRAST ENHANCEMENT; MICROENCAPSULATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; CHEMISTRY, PHYSICAL; CONTRAST MEDIA; GADOLINIUM; HETEROCYCLIC COMPOUNDS; LIPOSOMES; MAGNETIC RESONANCE IMAGING; ORGANOMETALLIC COMPOUNDS; PARTICLE SIZE; PHOSPHATIDYLGLYCEROLS;

EID: 0032897966     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0730-725X(98)00141-6     Document Type: Article

References (25)

1. Gore J.C., Sostmann H.D., Caride V.J. Liposomes for paramagnetic contrast enhancement in NMR imaging. J. Microencapsulation. 3:1986;251-264.
2. Krause W., Klopp R., Leike J., Sachse A., Schuhmann-Giamperi G. Liposomes in diagnostic imaging - Comparison of modalities - In vivo visualization of liposomes. J. Liposome Res. 5:1995;1-26.
3. Gregoriadis G., Florence A.T. Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential. Drugs. 45:1993;15-28.
4. Unger E., Fritz T., Wu G., Shen D., Kulik B., New T., Crowell M., Wilke N. Liposomal MR contrast agents. J. Liposome Res. 4:1994;811-834.
5. Tilcock C. Liposomal blood pool agents for nuclear medicine and magnetic resonance imaging. J. Liposome Res. 4:1994;909-936.
6. Bogdanov A.A., Martin C., Weissleder R., Brady T.J. Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: Preparation of ferrosomes. Biochim. Biophys. Acta. 1193:1994;212-218.
7. Storrs R.W., Tropper F.D., Li H.Y., Song C.K., Sipkins D.A., Kuniyoshi J.K., Bednarski M.D., William Strauss H., Li K.C.P. Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J. Magn. Reson. Imaging. 5:1995;719-724.
8. Pütz B., Barsky D., Schulten K. Mechanisms of liposomal contrast agents in magnetic resonance imaging. J. Liposome Res. 4:1994;771-808.
9. Unger E.C., Fritz T.A., Tilcock C., New T.E. Clearance of liposomal gadolinium in vivo decomplexation . J. Magn. Reson. Imaging. 1:1991;689-693.
10. Vander Elst L., Van Haverbeke Y., Goudemant J.F., Muller R.N. Stability assessment of gadolinium complexes by P-31 and H-1 relaxometry. Magn. Reson. Med. 31:1994;437-444.
11. Lasic D.D. Preparation of liposomes. Lasic D.D. Liposomes from Physics to Applications. 1993;67-73 Elsevier Science Publishers B.V, Amsterdam.
12. 31P NMR spectroscopy in liposome characterization. In: Proceedings of the European Society for Magnetic Resonance in Medicine and Biology. Prague, Czech Republic. Magma 4:301; 1996.
13. Hope M.J., Bally M.B., Webb G., Cullis P.R. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochim. Biophys. Acta. 812:1985;55-65.
14. Biltonen R.L., Lichtenberg D. The use of differential scanning calorimetry to characterize liposome preparations. Chem. Phys. Lipids. 64:1993;129-142.
15. Baĉic G., Niesman M.R., Bennett H.F., Magin R.L., Swartz H.M. Modulation of water proton relaxation rates by liposomes containing paramagnetic materials. Magn. Reson. Med. 6:1988;445-458.
16. Misselwitz, B.; Sachse, A. Interstitial MR lymphography using Gd-carrying liposomes. In: Proceedings of New Developments in Contrast Agent Research-5th Special Topic Seminar on Magnetic Resonance Contrast Agents. Santa Margherita Ligure, Italy. Acta Radiol. Suppl. 412, 38:51-55; 1997.
17. Tilcock C., Ahkong Q.F., Koenig S.H., Brown R.D. III, Davis M., Kabalka G. The design of liposomal paramagnetic MR agents: Effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates. Magn. Reson. Med. 27:1992;44-51.
18. 1 of solvent protons in suspensions of vesicles with entrapped paramagnetic ions. Magn. Reson. Med. 23:1992;275-286.
19. Barsky D., Pütz B., Schulten K. Theory of heterogeneous relaxation in compartmentalized tissues. Magn. Reson. Med. 37:1997;666-675.
20. Raux, J.C. Synthesis and characterization of magnetic liposomes. Master of Science Thesis, University of Mons-Hainaut, Mons, 1997, Belgium.
21. Andrasko J., Forsén S. NMR study of rapid water diffusion across lipid bilayers in dipalmitoyl lecithin vesicles. Biochem. Biophys. Res. Commun. 60:1974;813-819.
22. Mouritsen O.G., Jørgensen K., Hønger T. Permeability of lipid bilayers near the phase transition. Disalvo E.A., Simon S.A. Permeability and Stability of Lipid Bilayers. 1995;137-160 CRC Press Inc, Boca Raton, FL.
23. 3+-chelates, revisited. Magn. Reson. Med. 37:1997;730-735.
24. Vander Elst, L.; Maton, F.; Laurent, S.; Muller, R.N. Concentration effects on the multinuclear analysis of the paramagnetic relaxivity: A caveat. In: Book of abstracts: 13th European Experimental NMR Conference. Paris, France, 1996:144.
25. Lasic D.D. Structures of amphiphilic aggregates. Lasic D.D. Liposomes from Physics to Applications. 1993;56-61 Elsevier Science Publishers B.V, Amsterdam.