Novel radical-responsive MRI contrast agent based on paramagnetic liposomes

Magnetic Resonance in Chemistry

Volumn 41, Issue 8, 2003, Pages 585-588

  Gløgård, Christian ^a   Stensrud, Gry ^b   Aime, Silvio ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b Amersham Health AS   (Norway)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Contrast agent; Disulfide cleavage; Gadolinium; Liposomes; Magnetic resonance imaging; Physiological imaging; Radicals

Indexed keywords

CHELATION; COVALENT BONDS; GADOLINIUM; IRRADIATION; LIPOSOMES; MAGNETIC RESONANCE IMAGING; PARAMAGNETISM; PHOSPHOLIPIDS;

AGENT BASED; CONTRAST AGENT; DISULPHIDE BONDS; DISULPHIDE CLEAVAGE; GADOLINIA; GADOLINIUM CHELATES; MRI CONTRAST AGENTS; PHYSIOLOGICAL IMAGING; RADICAL; RELAXIVITY;

SULFUR COMPOUNDS;

1,4,7 TRIS(CARBOXYMETHYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7 TRIS(CARBOXYMETHYL) 10 (3 AMINO 2 HYDROXYPROPYL) 1,4,7,10 TETRAAZACYCLODODECANE; 1,4,7 TRIS(CARBOXYMETHYL) 10 (N TERT BUTYLOXYCARBONYL 3 AMINO 2 HYDROXYPROPYL) 1,4,7,10 TETRAAZACYCLODODECANE; CONTRAST MEDIUM; DISULFIDE; DITHIOTHREITOL; GADOLINIUM 1,4,7 TRIS(CARBOXYMETHYL) 10 (3 AMINO 2 HYDROXYPROPYL) 1,4,7,10 TETRAAZACYCLODODECANE; GADOLINIUM 1,4,7 TRIS(CARBOXYMETHYL) 10 (7 SULFHYDRYL 4 IMINO 2 HYDROXYPROPYL) 1,4,7,10 TETRAAZACYCLODODECANE; GADOLINIUM CHELATE; LIPOSOME; PHOSPHOLIPID; THIOL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; GAMMA IRRADIATION; NUCLEAR MAGNETIC RESONANCE IMAGING; SUPRAMOLECULAR CHEMISTRY; TECHNIQUE;

EID: 0142119587     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.1208     Document Type: Article

References (15)

1. Lowe MP, Parker D, Reany O, Aime S, Botta M, Castellano G, Gianolio E, Pagliarin R. J. Am. Chem. Soc. 2001; 123: 7601.
2. Fossheim SL, Ilyasov KA, Hennig J, Bjørnerud A. Acad. Radiol. 2000; 7: 1107.
3. (a) Louie AY, Huber MM, Ahrens ET, Rothbacher U, Moats R, Jacobs RE, Fraser SE, Meade TJ. Nature Biotechnol. 2000; 18: 321;
4. (b) Nivorozhkin AL, Kolodziej AF, Caravan P, Greenfield MT, Lauffer RB, McMurry TJ. Angew. Chem., Int. Ed. Engl. 2001; 40: 2903.
5. Sweeney MI, Yager JY, Walz W, Juurlink BHJ. Can. J. Physiol. Pharmacol. 1995; 73: 1525.
6. Dreher D, Junod AF. Eur. J. Cancer 1996; 32A: 30.
7. Gassen M, Youdim MBH. J. Neural Transmiss. 1999; 56: 193.
8. Jack CIA, Cottier B, Jackson MJ, Cassapi L, Fraser WD, Hind CRK. Int. J. Radiat. Oncol. Biol. Phys 1996; 34: 149.
9. Butkovskaya NI, Setser DW. Chem. Phys. Lett. 1999; 312: 37.
10. Lasic DD. Liposomes: from Physics to Applications. Elsevier: Amsterdam, 1993.
11. Lasic DD, Papahadjopoulos D (eds). Medical Applications of Liposomes. Elsevier: Amsterdam, 1998.
12. Merbach AE, Tóth É (eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. Wiley: Chichester, 2001.
13. Stark G. Biochim. Biophys. Acta 1991; 1071: 103.
14. Shultze L, Bulls AR. WO 96/28433/1996, 1996.
15. Cleland WW. Biochemistry 1964; 3: 480.