A calcium-sensitive magnetic resonance imaging contrast agent [18]

Journal of the American Chemical Society

Volumn 121, Issue 6, 1999, Pages 1413-1414

  Li, Wen Hong ^a   Fraser, Scott E ^a   Meade, Thomas J ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; EGTAZIC ACID; GADOLINIUM CHELATE; LANTHANIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; WATER;

DRUG SYNTHESIS; IMAGE ENHANCEMENT; LETTER; MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; SECOND MESSENGER; STRUCTURE ANALYSIS;

EID: 0033577002     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja983702l     Document Type: Letter

References (26)

1. Tsien, R. W.; Tsien, R. Y. Annu. Rev. Cell Biol. 1990, 6, 715-760.
2. (a) Li, W. H.; Llopis, J.; Whitney, M.; Zlokarnik, G.; Tsien, R. Y. Nature 1998, 392, 936-941.
3. (b) Meldolesi, J. Nature 1998, 392, 863.
4. (c) Berridge, M. J. Neuron 1998, 21, 13-26.
5. (a) Tsien, R. Y.; Waggoner, A. In Handbook of Biological Confocal Microscopy; 2nd ed.; Pawley, J. B., Ed.; Plenum Press: New York, 1995; pp 267-280.
6. (b) Tsien, R. Y. Chem. Eng. News 1994, 72, 34-44.
7. (c) Czarnik, A. W., Ed. ACS Symposium Series 538; American Chemical Society: Washington, DC, 1993.
8. (a) Huber, M. M.; Staubli, A. B.; Kustedjo, K.; Gray, M. H. B.; Shih, J.; Fraser, S. E.; Jacobs, R. E.; Meade, T. J. Bioconjugate Chem. 1998, 9, 242-249.
9. (b) Bowtell, R. W.; Sharp, J. C.; Mansfield, P.; Hsu, E. W.; Aiken, N.; Horsman, A. Magn. Reson. Med. 1995, 33, 790-794.
10. (c) Kayyem, J. F.; Kumar, R. M.; Fraser, S. E.; Meade, T. J. Chem. Biol. 1995, 2, 615-620.
11. (d) Liang, P.; Lauterbur, P. C. IEEE Trans. Med. Imaging 1994, 13, 677-686.
12. (e) Jacobs, R. E.; Fraser, S. E. Science 1994, 263, 681-684.
13. (f) Meilin, A. F.; Cofer, G. P.; Smith, B. R.; Suddarth, S. A.; Hedlund, L. W.; Johnson, G. A. Magn. Reson. Med. 1994, 13, 677-686.
14. (g) Kuhn, W. Angew. Chem., Int. Ed. Engl. 1990, 29, 1-19.
15. Moats, R. A.; Fraser, S. E.; Meade, T. J. Angew. Chem., Int. Ed. Engl. 1997, 36, 726-728.
16. 2+ concentration, (a) Clarke, S. D.; Metcalfe, J. C.; Smith, G. A. J. Chem. Soc., Perkin Trans. 2 1993, 1187-1194. (b) Marban, E.; Kitakaze, M.; Koretsune, Y.; Yue, D. T.; Chacko, V. P.; Pike, M. M. Circ. Res. 1990, 66, 1255-1267.
17. 2+ concentration, (a) Clarke, S. D.; Metcalfe, J. C.; Smith, G. A. J. Chem. Soc., Perkin Trans. 2 1993, 1187-1194. (b) Marban, E.; Kitakaze, M.; Koretsune, Y.; Yue, D. T.; Chacko, V. P.; Pike, M. M. Circ. Res. 1990, 66, 1255-1267.
18. (a) Aime, S.; Botta, M.; Fasano, M.; Terreno, E. Chem. Soc. Rev. 1998, 27, 19-29.
19. (b) Alexander, V. Chem. Rev. 1995, 95, 273-342.
20. (a) Grynkiewicz, G.; Poenie, M.; Tsien, R. Y. J. Biol. Chem. 1985, 260, 3440-3450.
21. (b) Tsien, R. Y. Biochemistry 1980, 19, 2396-2404.
22. Kumar, K.; Chang, C. A.; Tweedle, M. F. Inorg. Chem. 1993, 32, 587-593.
23. 3+ ion based on data from TI and luminescence lifetime measurements.
24. 1 vs [DOPTA-Gd] (0, 0.2, 0.3, 0.4 mM).
25. 1, after subtracting the longitudinal relaxation rate in the absence of DOPTA-Gd.
26. 2 at 25°C. The pH was varied from 6.80 to 7.40 in 0.2 pH unit steps with HCl or KOH.