Physical, chemical and biological evaluations of CMD-A2-Gd-DOTA: A new paramagnetic dextran polymer

Acta Radiologica, Supplement

Volumn 38, Issue 412, 1997, Pages 91-99

  Corot, C ^a,b   Schaefer, M ^a   Beaute S ^a   Bourrinet, P ^a   Zehaf, S ^a   Benize V ^a   Sabatou, M ^a   Meyer, D ^a  

^a Laboratoire Guerbet   (France)

^b ZI de l'Islon   (France)

Author keywords

Contrast agents, paramagnetic polymer; Dextran derivative; Gd DOTA, experimental

Indexed keywords

CARBOXYMETHYL DEXTRAN A2 GADOLINIUM DOTA; CARBOXYMETHYL-DEXTRAN-A2-GADOLINIUM-DOTA; CARBOXYMETHYLDEXTRAN; CONTRAST MEDIUM; DEXTRAN; GADOLINIUM; GADOLINIUM 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE; GADOTERIC ACID; HETEROCYCLIC COMPOUND; ORGANOMETALLIC COMPOUND;

ANIMAL; ARTICLE; CHEMISTRY; LD 50; MALE; MOLECULAR WEIGHT; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; RABBIT; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CONTRAST MEDIA; DEXTRANS; GADOLINIUM; HETEROCYCLIC COMPOUNDS; LETHAL DOSE 50; MAGNETIC RESONANCE IMAGING; MALE; MICE; MOLECULAR WEIGHT; ORGANOMETALLIC COMPOUNDS; RABBITS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 5644229749     PISSN: 03655954     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ARMITAGE F. E., RICHARDSON D. E. & LI K. C.: Polymeric contrast agents for magnetic resonance imaging. Synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides. Bioconjug. Chem. 1 (1990), 365.
2. ARTEAGA C., CANET E., OVIZE M., JANIER M. & REVEL D.: Myocardial perfusion assessed by subsecond magnetic resonance imaging with a paramagnetic macromolecular contrast agent. Invest. Radiol. 29 (1994), S54.
3. ARTURSSON G. & WALLENIUS G.: The intravascular persistence of dextran of different molecular sizes in normal humans. Scand. J. Clin. Lab. Invest. 16 (1964), 76.
4. ARTURSSON G. & WALLENIUS G.: The renal clearance of dextran of different molecular sizes in normal humans. Scand. J. Clin. Lab. Invest. 16 (1964), 81.
5. BLIGH S. W. A., HARDING C. T., SADLER P. J. et al.: Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging. Magn. Reson. Med. 17 (1991), 516.
6. BRENNER B. M. & BEEUWKES R.: The renal circulations. Hosp. Pract. 13(1978), 35.
7. COROT C., BELLEVILLE J., REVEL D., AMIEL M. & ELOY R.: In vitro evaluation of the effects of Gd-DOTA and Gd-DTPA in different biological systems. Diagn. Interv. Radiol. 2 (1990), 197.
8. COROT C., HENTSCH A. M. & CURTELIN L.: Interaction of gadolinium complexes with metal-dependent biological systems. Invest. Radiol. 29 Suppl. 2 (1994), S164.
9. DOUCET D., MEYER D. & CHAMBON C.: Blood-pool X-ray contrast agents. Evaluation of a new iodinated polymer. Invest. Radiol. 26 (1991), S53.
10. ELOY R., COROT C. & BELLEVILLE J.: Review paper - Contrast media for angiography. Physicochemical properties, pharmacokinetics and biocompatibility. Clin. Mat. 7 (1991), 89.
11. GIBBY W. A., BOGDAN A. & OVITT W.: Cross-linked DTPA polysaccharides for magnetic resonance imaging. Synthesis and relaxation properties. Invest. Radiol. 24 (1989), 302.
12. KUWATSURU R., SHAMES D. M., MÜHLER A. et al.: Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging. Magn. Reson. Med. 30 (1993), 76.
13. LOUBEYRE P., CANET E., ZHAO S., BENDERBOUS S., AMIEL M. & REVEL D.: Carboxymethyl-dextran-gadolinium-DTPA as a blood-pool contrast agent for magnetic resonance angiography. Invest. Radiol. 31 (1996), 288.
14. MANDUTEANU I., COROT C., SIMIONESCU N., MEYER D. & SIMIONESCU M.: Ultrastructural investigation on the vascular transport of an iodinated macromolecular contrast medium (MMCM). Acad. Radiol. 3 (1996), 00.
15. MATTHEWS S. E., POUTON C. W. & THREADGILL M. D.: Macromolecular systems for chemotherapy and magnetic resonance imaging. Adv. Drug Deliv. Rev. 18 (1996), 219.
16. MEYER D., SCHAEFER M. & BOUILLOT A.: Paramagnetic dextrans as magnetic resonance contrast agents. Invest. Radiol. 26 (1991), S50.
17. MEYER D., SCHAEFER M. & CHAMBON C.: Paramagnetic dextrans as magnetic resonance blood pool tracers. Invest. Radiol. 29 (1994), S90.
18. PARIS D., MEYER D. & NIGRETTO J. M.: Synthesis and characterization of dextran radiocontrast carriers. Ether methylamide derivatives. Macromol. Chem. 192 (1991), 2603.
19. 2O)] complexes along the lanthanide(III) series. Inorg. Chem. 34 (1995), 4447.
20. REVEL D., CHAMBON C. & HAVARD P.: Iodinated polymer as blood-pool contrast agent. Computed tomography evaluation in rabbits. Invest. Radiol. 26 (1991), S57.
21. RONGVED P. & KLAVENESS J.: Water-soluble polysaccharides as carriers of paramagnetic contrast agents for magnetic resonance imaging. Synthesis and relaxation properties. Carbohydr. Res. 214 (1991), 315.
22. SCHUHMANN-GIAMPIERI G., SCHMITT-WILLICH H. & FRENZEL T: In vivo and in vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging. Invest. Radiol. 26 (1991), 969.
23. SHAMES D. M., KUWATSURU R., VEXLER V., MÜHLER A. & BRASCH R. C.: Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging. A quantitative noninvasive technique. Mgn. Reson. Med. 29 (1993), 616.
24. THOREN L.: Dextran as a plasma volume substitute. Blood substitutes and plasma expanders, p. 265. Alan R. Liss Inc., New York 1978.
25. WANG S. C., WIKSTRÖM M. G. & WHITE D. L.: Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agents. Imaging characteristics in normal rat tissues. Radiology 175 (1990), 483.
26. WIENER E. C., BRECHBIEL M. W. & BROTHERS H.: Dendrimer-based metal chelates. A new class of magnetic resonance imaging contrast agents. Magn. Reson. Med. 31 (1994), 1.