Synthesis and relaxometry of high-generation (G = 5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates

Journal of Magnetic Resonance Imaging

Volumn 9, Issue 2, 1999, Pages 348-352

  Bryant Jr , L Henry ^a   Brechbiel, Martin W ^b   Wu, Chuanchu ^b   Bulte, Jeff W M ^a   Herynek, Vít ^c   Frank, Joseph A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Dendrimer; Gd(DOTA); Macromolecular contrast agent; Relaxometry

Indexed keywords

CHELATE; DENDRIMER; ETHYLENEDIAMINE DERIVATIVE; GADOLINIUM PENTETATE DERIVATIVE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; STARBURST; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

CONTRAST MEDIA; GADOLINIUM; HETEROCYCLIC COMPOUNDS; HUMANS; MACROMOLECULAR SUBSTANCES; ORGANOMETALLIC COMPOUNDS;

EID: 0344766109     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2586(199902)9:2<348::AID-JMRI30>3.0.CO;2-J     Document Type: Article

References (18)

1. Wiener EC, Brechbiel MW, Brothers H, et al. Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents. Magn Reson Med 1994;31:1-8.
2. Adam G, Neuerburg J, Spüntrup E, Mühler A, Scherer K, Günther RW. Gd-DTPA-cascade-polymer: potential blood pool contrast agent for MR imaging. J Magn Reson Imaging 1994;4:462-466.
3. Schwickert HC, Roberts TPL, Mühler A, Stiskal M, Demsar F, Brasch RC. Angiographic properties of Gd-DTPA-24-cascade-polymer - a new macromolecular MR contrast agent. Eur J Radiol 1995;20:144-150.
4. Adam G, Mühler A, Spüntrup E, et al. Differentiation of spontaneous canine breast tumors using dynamic magnetic resonance imaging with 24-gadolinium-DTPA- cascade-polymer, a new blood-pool agent. Invest Radiol 1996;31:267-274.
5. Bourne MW, Margerun L, Hylton N, et al. Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body. J Magn Reson Imaging 1996;6:305-310.
6. Wiener EC, Konda S, Shadron A, Brechbiel M, Gansow O. Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor. Invest Radiol 1997;32:748-754.
7. Tóth E, Pubanz D, Vauthey S, Helm L, Merbach AE. The role of water exchange in attaining maximum relaxivities for dendrimeric MRI contrast agents. Chem Eur J 1996;2:1607-1615.
8. Margerum LD, Campion BK, Koo M, et al. Gadolinium(III) DO3A macrocycles and polyethylene glycol coupled to dendrimers: effect of molecular weight on physical and biological properties of macromolecular magnetic resonance imaging contrast agents. J Alloys Comp 1997;249:185-190.
9. Bulte JWM, Wu C, Brechbiel MW, Brooks RA, Vymazal J, Holla M, Frank JA. Dy-DOTA-PAMAM dendrimers as macromolecular T2 contrast agents: preparation and relaxometry. Invest Radiol 1998; 33:841-845.
10. Tomalia DA, Baker H, Dewald J, et al. A new class of polymers: starburst-dendritic macromolecules. Polymer J 1985;17:117-132.
11. Tomalia DA, Naylor AM, Goddard WA, Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew Chem Int Ed Engl 1990;29:138-175.
12. McMurry TJ, Brechbiel M, Kumar K, Gansow OA. Convenient synthesis of bifunctional tetraaza macrocycles. Bioconj Chem 1992; 3:108-117.
13. Wu C, Brechbiel MW, Kozak RW, Gansow OA. Metal-chelate-dendrimer- antibody constructs for use in radioimmunotherapy and imaging. Biorg Med Chem Lett 1994;4:449-454.
14. Kumar K, Chang CA, Francesconi LC, et al. Synthesis, stability, and structure of gadolinium(III) and yttrium(III) macrocyclic poly(amino carboxylates). Inorg Chem 1994;33:3567-3575.
15. Koenig SH, Brown RD. Relaxation of solvent protons by paramagnetic ions and its dependence on magnetic field and chemical environment: implications for NMR imaging. Magn Reson Med 1984;1:478-496.
16. Wiener EC, Auteri FP, Chen WC, et al. Molecular dynamics of ion-chelate complexes attached to dendrimers. J Am Chem Soc 1996;118:7774-7782.
17. Aime S, Botta M, Fasano M, et al. NMR evidence for a long exchange lifetime for the coordinated water in Ln(IIl)-Bis(methylamide)-DTPA complexes (Ln = Gd, Dy). Inorg Chem 1994;33:4707-4771.
18. Kellar KE, Henrichs PM, Hollister R, Koenig SH, Eck J, Wei D. High relaxivity linear Gd(DTPA)-polymer conjugates: the role of hydrophobic interactions. Magn Reson Med 1997;38:712-716.