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Volumn 49, Issue 1, 2006, Pages 19-27

Expression of phospho-Akt and PTEN proteins in human breast cancer in relation to tumor progression and patient survival

Author keywords

Breast cancer; Immunohistochemistry; Phosphatase and tensin homolog detected on chromosome ten; Phosphorylated Akt; Prognosis

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE B;

EID: 33645333934     PISSN: 05135710     EISSN: 05135710     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (35)
  • 1
    • 15644381754 scopus 로고    scopus 로고
    • Role of translocation in the activation and function of protein kinase B
    • Andjelkovic M, Alessi DR, Meier R. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997;272:31515-31524.
    • (1997) J Biol Chem , vol.272 , pp. 31515-31524
    • Andjelkovic, M.1    Alessi, D.R.2    Meier, R.3
  • 2
    • 0035872199 scopus 로고    scopus 로고
    • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard J, Clark AS, Ni Y, Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001;61:3986-3997.
    • (2001) Cancer Res , vol.61 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3    Dennis, P.A.4
  • 3
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995;376:599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 4
    • 0035971181 scopus 로고    scopus 로고
    • Phophatidylinositol 3-kinase /AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Nakshatri H. Phophatidylinositol 3-kinase /AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 2001;276:9817-24.
    • (2001) J Biol Chem , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Nakshatri, H.5
  • 6
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinase: Kinase activation by phosphoinostitide-dependent phosphoryylation
    • Chan TO, Rittenhouse SE , Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinase: kinase activation by phosphoinostitide- dependent phosphoryylation. Annu Rev Biochem 1999;68:965-1014.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 7
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • Clark AS, West K, Streicher S, Dennis PA. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther 2002;1:707-717.
    • (2002) Mol Cancer Ther , vol.1 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3    Dennis, P.A.4
  • 8
  • 9
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 10
    • 0034920457 scopus 로고    scopus 로고
    • Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
    • Depowski PL, Rosenthal SI, Ross JS. Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer. Mod Pathol 2001;14:672-676.
    • (2001) Mod Pathol , vol.14 , pp. 672-676
    • Depowski, P.L.1    Rosenthal, S.I.2    Ross, J.S.3
  • 11
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate
    • Franke TF, Kaplan DR, Cantley LC, Toxer A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate. Science 1997;275:665-668.
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toxer, A.4
  • 12
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
    • Gingras AC, Kennedy SG, O,Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev 1998;12:502-513.
    • (1998) Genes Dev , vol.12 , pp. 502-513
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 13
    • 0031782480 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
    • Hajduch E, Alessi DR, Hemming BA, Hundal HS. Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 1998;47:1006-1013.
    • (1998) Diabetes , vol.47 , pp. 1006-1013
    • Hajduch, E.1    Alessi, D.R.2    Hemming, B.A.3    Hundal, H.S.4
  • 14
    • 0037096804 scopus 로고    scopus 로고
    • Phosphorylation of Akt/PKB is required for suppression and cancer cell apoptosis and tumor progression in human colorectal carcinoma
    • Itoh N, Semba S, Ito M, Takeda H, Kawata S, Yamakawa M. Phosphorylation of Akt/PKB is required for suppression and cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 2002;94:3127-3134.
    • (2002) Cancer , vol.94 , pp. 3127-3134
    • Itoh, N.1    Semba, S.2    Ito, M.3    Takeda, H.4    Kawata, S.5    Yamakawa, M.6
  • 15
    • 0034327361 scopus 로고    scopus 로고
    • Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy
    • Izuishi K, Kato K, Ogura T, Kinoshita T, Esumi H. Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. Cancer Res 2000;60:6201-6207.
    • (2000) Cancer Res , vol.60 , pp. 6201-6207
    • Izuishi, K.1    Kato, K.2    Ogura, T.3    Kinoshita, T.4    Esumi, H.5
  • 16
    • 0035726273 scopus 로고    scopus 로고
    • PTEN expression in breast and endometrial cancer: Correlation with steroid hormone receptor status
    • Kappes H, Goemann C, Bamberger AM, Loning T, Milde-Langosch K. PTEN expression in breast and endometrial cancer: correlation with steroid hormone receptor status. Pathobiology 2001;69:136-142.
    • (2001) Pathobiology , vol.69 , pp. 136-142
    • Kappes, H.1    Goemann, C.2    Bamberger, A.M.3    Loning, T.4    Milde-Langosch, K.5
  • 17
    • 0032563207 scopus 로고    scopus 로고
    • Phosphoinositide-3 kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway
    • Khwaja A, Lehmann K, Marte BM, Downward J. Phosphoinositide-3 kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. J Biol Chem 1998;273:18793-18801.
    • (1998) J Biol Chem , vol.273 , pp. 18793-18801
    • Khwaja, A.1    Lehmann, K.2    Marte, B.M.3    Downward, J.4
  • 19
    • 0033571477 scopus 로고    scopus 로고
    • PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
    • Liang-Ping W, Wendy M, Charis E. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. C ancer Res 1999;59:5808-5814.
    • (1999) C ancer Res , vol.59 , pp. 5808-5814
    • Liang-Ping, W.1    Wendy, M.2    Charis, E.3
  • 20
    • 0032853452 scopus 로고    scopus 로고
    • PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
    • Marsh DJ, Kum JB, Lunetta KL, Bennett MJ, Gorlin RJ, Ahmed SF, et al. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet 1999;8:1461-1472.
    • (1999) Hum Mol Genet , vol.8 , pp. 1461-1472
    • Marsh, D.J.1    Kum, J.B.2    Lunetta, K.L.3    Bennett, M.J.4    Gorlin, R.J.5    Ahmed, S.F.6
  • 21
    • 0037686249 scopus 로고    scopus 로고
    • Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer
    • Maulik G, Madhiwala P, Brooks S, Ma PC, Kijima T, Tibaldi EV, et al. Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med 2002;6:539-53.
    • (2002) J Cell Mol Med , vol.6 , pp. 539-553
    • Maulik, G.1    Madhiwala, P.2    Brooks, S.3    Ma, P.C.4    Kijima, T.5    Tibaldi, E.V.6
  • 22
    • 0034742120 scopus 로고    scopus 로고
    • AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
    • Mei Sun, Gen Wang, June E Paciga, Richard I Feldman, Zeng-Qiang Yuan, Xiao-Ling Ma, et al. AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathology 2001;159:431-437.
    • (2001) Am J Pathology , vol.159 , pp. 431-437
    • Sun, M.1    Wang, G.2    Paciga, J.E.3    Feldman, R.I.4    Yuan, Z.-Q.5    Ma, X.-L.6
  • 23
    • 0030727172 scopus 로고    scopus 로고
    • Mitogenic activation, phosphorylation, and nucler translocation of protein kinase Bα
    • Meier R, Alessi DR, Cron P. Mitogenic activation, phosphorylation, and nucler translocation of protein kinase Bα. J Biol Chem 1997;272:30491-30497.
    • (1997) J Biol Chem , vol.272 , pp. 30491-30497
    • Meier, R.1    Alessi, D.R.2    Cron, P.3
  • 24
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • Nakatani K, Thompson DA, Barthel A. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Pathol 1999;274:21528-21532.
    • (1999) J Biol Pathol , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3
  • 26
    • 0033607784 scopus 로고    scopus 로고
    • Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
    • Rommel C, Clarke BA, Zimmermann S, Nunez L, Rossman R, Reid K, et al. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 1999;286:1738-1741.
    • (1999) Science , vol.286 , pp. 1738-1741
    • Rommel, C.1    Clarke, B.A.2    Zimmermann, S.3    Nunez, L.4    Rossman, R.5    Reid, K.6
  • 28
    • 0036278927 scopus 로고    scopus 로고
    • The in vitro and in vivo effects of 2-(4-Morpholinyl)-8-phenylchromone (LY294002), a specific inhibitor of phsphatidylinositol 3-kinase, in human colon cancer cells
    • Semba S, Itoh N, Ito M, Harada M, Yamakawa M. The in vitro and in vivo effects of 2-(4-Morpholinyl)-8-phenylchromone (LY294002), a specific inhibitor of phsphatidylinositol 3-kinase, in human colon cancer cells. Clin Cancer Res 2002;8:1957-1963.
    • (2002) Clin Cancer Res , vol.8 , pp. 1957-1963
    • Semba, S.1    Itoh, N.2    Ito, M.3    Harada, M.4    Yamakawa, M.5
  • 29
    • 0037457314 scopus 로고    scopus 로고
    • Dysregulated PTEN-PKB and negative receptor status in human breast cancer
    • Shi W, Zhang X, Pintilie M, Ma N, Miller N, Banerjee D, et al. Dysregulated PTEN-PKB and negative receptor status in human breast cancer. Int J Cancer 2003;104:195-203.
    • (2003) Int J Cancer , vol.104 , pp. 195-203
    • Shi, W.1    Zhang, X.2    Pintilie, M.3    Ma, N.4    Miller, N.5    Banerjee, D.6
  • 30
    • 0032619980 scopus 로고    scopus 로고
    • The 5th edition of the TNM classification malignant tumor of the breast
    • Stmad P. The 5th edition of the TNM classification malignant tumor of the breast. Cesk Gynecol 1999;64:54-57.
    • (1999) Cesk Gynecol , vol.64 , pp. 54-57
    • Stmad, P.1
  • 31
    • 13044305289 scopus 로고    scopus 로고
    • PTEN modulates cell cycle survival by regulating phosphatidylinositol 3,4,5-triphosphate and Akt/protein kinase B signaling pathway
    • USA
    • Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, et al. PTEN modulates cell cycle survival by regulating phosphatidylinositol 3,4,5-triphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 1999;96:6199-6204.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 6199-6204
    • Sun, H.1    Lesche, R.2    Li, D.M.3    Liliental, J.4    Zhang, H.5    Gao, J.6
  • 32
    • 0032557646 scopus 로고    scopus 로고
    • Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
    • Van Weeren PC, de Bruyn KM, de Vries-Smits AM, van Lint J, Burgering BM. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J Biol Chem 1998;273:13150-13156.
    • (1998) J Biol Chem , vol.273 , pp. 13150-13156
    • Van Weeren, P.C.1    De Bruyn, K.M.2    De Vries-Smits, A.M.3    Van Lint, J.4    Burgering, B.M.5
  • 34
    • 0033571477 scopus 로고    scopus 로고
    • PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
    • Weng LP, Smith WM, Dahia PL, Ziebold U, Gil E, Lees JA, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res 1999;59:5808-5814.
    • (1999) Cancer Res , vol.59 , pp. 5808-5814
    • Weng, L.P.1    Smith, W.M.2    Dahia, P.L.3    Ziebold, U.4    Gil, E.5    Lees, J.A.6
  • 35
    • 0035928416 scopus 로고    scopus 로고
    • Association of germline mutation in the PTEN tumor suppressor gene and Proteus and Proteus-like syndrome
    • Zhou XP, Hampel H, Thiele H, Gorlin RJ, Hennekam RC, Parisi M, et al. Association of germline mutation in the PTEN tumor suppressor gene and Proteus and Proteus-like syndrome. Lancet 2001;358:210-211.
    • (2001) Lancet , vol.358 , pp. 210-211
    • Zhou, X.P.1    Hampel, H.2    Thiele, H.3    Gorlin, R.J.4    Hennekam, R.C.5    Parisi, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.