Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy

Cancer Research

Volumn 60, Issue 21, 2000, Pages 6201-6207

  Izuishi, Kunihiko ^a   Kato, Kazuyoshi ^a   Ogura, Tsutomu ^a   Kinoshita, Taira ^a   Esumi, Hiroyasu ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; TROGLITAZONE; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CANCER; METABOLIC INHIBITION; PANCREAS CANCER; PRIORITY JOURNAL; STARVATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHROMANS; CHROMONES; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MORPHOLINES; PANCREATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; STARVATION; STOMACH NEOPLASMS; THIAZOLES; THIAZOLIDINEDIONES; TUMOR CELLS, CULTURED;

EID: 0034327361     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Oncogenic alteration of metabolism
2. Cell and environment interactions in tumor microregions: The multicell spheroid model
3. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
4. Angiogenesis as a target for tumor treatment
5. Designing therapies that target tumor blood vessels
6. Effects of angiogenesis inhibitors on multistage carcinogenosis in mice
7. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21 (wafl/cip 1), and erythropoietin
8. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
9. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
10. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
11. Angiogenin is involved in morphological changes and angiogenesis in the ovary
12. A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone
13. 2-M delay
14. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase
15. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
16. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
17. Hypoxia-induced metastasis of human melanoma cells: Involvement of vascular endothelial growth factor-mediated angiogenesis
18. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
19. Inflammatory pancreatic masses: Differentiation from ductal carcinomas with contrast-enhanced sonography using carbon dioxide microbubbles
20. Assessment of tumor vascularity in hepatocellular carcinoma: Comparison of power Doppler US and color Doppler US
21. Interacting genes in nematode dauer larva formation
22. Sensory control of dauer larva formation in Caenorhabditis elegans
23. Developmental regulation of energy metabolism in Caenorhabditis elegans
24. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
25. PIK3CA is implicated as an oncogene in ovarian cancer
26. Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer
27. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
28. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
29. The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway
30. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
31. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
32. Constitutive activation of protein kinase B α by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
33. Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
34. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
35. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
36. Use of hexose transport mutants to examine the expression and properties of the rat myoblast GLUT 1 transport process
37. Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3L1 adipocytes. Effect of chronic glucose deprivation
38. Derepression of amino acid transport by amino acid starvation in rat hepatoma cells
39. Substrate-dependent adaptive regulation and trans-inhibition of system A-mediated amino acid transport. Studies using rat hepatoma plasma membrane vesicles
40. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
41. Dealing with energy demand: The AMP-activated protein kinase
42. The AMP-activated protein kinase: Fuel gauge of the mammalian cell?
43. Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative
44. Effect of troglitazone on plasma lipid metabolism and lipoprotein lipase
45. Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats
46. Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells
47. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
48. Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
49. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
50. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
51. Chemoembolization of hepatic malignancies
52. Blood supply of neoplasms of the liver
53. Perfusion of colorectal hepatic metastases. Relative distribution of flow from the hepatic artery and portal vein
54. Tumor and liver drug uptake following hepatic artery and portal vein infusion