메뉴 건너뛰기




Volumn 67, Issue 1, 2006, Pages 127-133

Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TUMOR SUPPRESSOR PROTEIN;

EID: 33645221622     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.1.127     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0016265064 scopus 로고
    • Epidemiological analysis of the most prevalent sites and types of canine neoplasia observed in a veterinary hospital
    • Cohen D, Reif JS, Brodey RS, et al. Epidemiological analysis of the most prevalent sites and types of canine neoplasia observed in a veterinary hospital. Cancer Res 1974;34:2859-2868.
    • (1974) Cancer Res , vol.34 , pp. 2859-2868
    • Cohen, D.1    Reif, J.S.2    Brodey, R.S.3
  • 2
    • 0014207352 scopus 로고
    • The biological behavior of canine mammary neoplasms
    • Fidler IJ, Brodey RS. The biological behavior of canine mammary neoplasms. J Am Vet Med Assoc 1967;151:1311-1318.
    • (1967) J Am Vet Med Assoc , vol.151 , pp. 1311-1318
    • Fidler, I.J.1    Brodey, R.S.2
  • 3
    • 0016023048 scopus 로고
    • Comparative aspects of mammary tumors
    • Hamilton JM. Comparative aspects of mammary tumors. Adv Cancer Res 1974;19:1-45.
    • (1974) Adv Cancer Res , vol.19 , pp. 1-45
    • Hamilton, J.M.1
  • 4
    • 0018687642 scopus 로고
    • Occurrence of mammary neoplasms in bitches in relation to breed, age, tumour type, and geographical region from which reported
    • Priester WA. Occurrence of mammary neoplasms in bitches in relation to breed, age, tumour type, and geographical region from which reported. J Small Anim Pract 1979;20:1-11.
    • (1979) J Small Anim Pract , vol.20 , pp. 1-11
    • Priester, W.A.1
  • 5
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • Haas-Kogan D, Shalev N, Wong M, et al. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol 1998; 8:1195-1198.
    • (1998) Curr Biol , vol.8 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3
  • 6
    • 0030799909 scopus 로고    scopus 로고
    • Somatic mutations of PTEN in glioblastoma multiforme
    • Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997;57:4183-4186.
    • (1997) Cancer Res , vol.57 , pp. 4183-4186
    • Wang, S.I.1    Puc, J.2    Li, J.3
  • 7
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Goldberg P, Thor SP, Birck A, et al. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997;57:3660-3663.
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Goldberg, P.1    Thor, S.P.2    Birck, A.3
  • 8
    • 15444349266 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
    • Cairns P, Okami K, Halachmi S, et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 1997; 57:4997-5000.
    • (1997) Cancer Res , vol.57 , pp. 4997-5000
    • Cairns, P.1    Okami, K.2    Halachmi, S.3
  • 9
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 1997;57:3935-3940.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 10
    • 0032857217 scopus 로고    scopus 로고
    • Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas ofthe breast
    • Perren A, Weng LP, Boag AH, et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas ofthe breast. Am J Pathol 1999;155:1253-1260.
    • (1999) Am J Pathol , vol.155 , pp. 1253-1260
    • Perren, A.1    Weng, L.P.2    Boag, A.H.3
  • 11
    • 0030801275 scopus 로고    scopus 로고
    • Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
    • Rhei E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 1997;57:3657-3659.
    • (1997) Cancer Res , vol.57 , pp. 3657-3659
    • Rhei, E.1    Kang, L.2    Bogomolniy, F.3
  • 12
    • 0036637521 scopus 로고    scopus 로고
    • Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma
    • Koenig A, Bianco SR, Fosmire S, et al. Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma. Vet Pathol 2002;39:458-472.
    • (2002) Vet Pathol , vol.39 , pp. 458-472
    • Koenig, A.1    Bianco, S.R.2    Fosmire, S.3
  • 13
    • 0036583531 scopus 로고    scopus 로고
    • Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors
    • Levine RA, Forest T, Smith C. Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. Vet Pathol 2002;39:372-378.
    • (2002) Vet Pathol , vol.39 , pp. 372-378
    • Levine, R.A.1    Forest, T.2    Smith, C.3
  • 14
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 15
    • 0030837555 scopus 로고    scopus 로고
    • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
    • Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A 1997;94:9052-9057.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9052-9057
    • Myers, M.P.1    Stolarov, J.P.2    Eng, C.3
  • 16
    • 6344246440 scopus 로고    scopus 로고
    • PTEN promoter is methylated in a proportion of invasive breast cancers
    • Khan S, Kumagai T, Vora J, et al. PTEN promoter is methylated in a proportion of invasive breast cancers. Int J Cancer 2004;112:407-410.
    • (2004) Int J Cancer , vol.112 , pp. 407-410
    • Khan, S.1    Kumagai, T.2    Vora, J.3
  • 17
    • 0032534963 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
    • Li J, Simpson L, Takahashi M, et al. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res 1998;58:5667-5672.
    • (1998) Cancer Res , vol.58 , pp. 5667-5672
    • Li, J.1    Simpson, L.2    Takahashi, M.3
  • 18
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    • Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA 1998;95:13513-13518.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13513-13518
    • Myers, M.P.1    Pass, I.2    Batty, I.H.3
  • 19
    • 0033514509 scopus 로고    scopus 로고
    • Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Ramaswamy S, Nakamura N, Vazquez F, et al. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1999;96:2110-2115.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2110-2115
    • Ramaswamy, S.1    Nakamura, N.2    Vazquez, F.3
  • 20
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998;95:29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    de la Pompa, J.L.3
  • 21
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • Wu X, Senechal K, Neshat MS, et al. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 1998;95:15587-15591.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3
  • 22
    • 0037192768 scopus 로고    scopus 로고
    • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
    • Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 2002;277:10760-10766.
    • (2002) J Biol Chem , vol.277 , pp. 10760-10766
    • Huang, J.1    Kontos, C.D.2
  • 24
    • 0032583122 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
    • Gu J, Tamura M, Yamada KM. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol 1998;143:1375-1383.
    • (1998) J Cell Biol , vol.143 , pp. 1375-1383
    • Gu, J.1    Tamura, M.2    Yamada, K.M.3
  • 25
    • 0033556443 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130Cas
    • Tamura M, Gu J, Takino T, et al. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res 1999;59:442-449.
    • (1999) Cancer Res , vol.59 , pp. 442-449
    • Tamura, M.1    Gu, J.2    Takino, T.3
  • 26
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, et al. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998;280:1614-1617.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3
  • 27
    • 0033571477 scopus 로고    scopus 로고
    • PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
    • Weng LP, Smith WM, Dahia PL, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res 1999;59:5808-5814.
    • (1999) Cancer Res , vol.59 , pp. 5808-5814
    • Weng, L.P.1    Smith, W.M.2    Dahia, P.L.3
  • 28
    • 4143138570 scopus 로고    scopus 로고
    • Promoter methylation of the PTEN gene is a common molecular change in breast cancer
    • Garcia JM, Silva J, Pena C, et al. Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer 2004;41:117-124.
    • (2004) Genes Chromosomes Cancer , vol.41 , pp. 117-124
    • Garcia, J.M.1    Silva, J.2    Pena, C.3
  • 29
    • 6344246440 scopus 로고    scopus 로고
    • PTEN promoter is methylated in a proportion of invasive breast cancers
    • Khan S, Kumagai T, Vora J, et al. PTEN promoter is methylated in a proportion of invasive breast cancers. Int J Cancer 2004;112:407-410.
    • (2004) Int J Cancer , vol.112 , pp. 407-410
    • Khan, S.1    Kumagai, T.2    Vora, J.3
  • 30
    • 3042842752 scopus 로고    scopus 로고
    • Mutation and overexpression of p53 as a prognostic factor in canine mammary tumors
    • Lee CH, Kim WH, Lim JH, et al. Mutation and overexpression of p53 as a prognostic factor in canine mammary tumors. J Vet Sci 2004;5:63-69.
    • (2004) J Vet Sci , vol.5 , pp. 63-69
    • Lee, C.H.1    Kim, W.H.2    Lim, J.H.3
  • 31
    • 0034186688 scopus 로고    scopus 로고
    • Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: Clinical and pathologic associations and prognostic significance
    • Nieto A, Pena L, Perez-Alenza MD, et al. Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance. Vet Pathol 2000;37:239-247.
    • (2000) Vet Pathol , vol.37 , pp. 239-247
    • Nieto, A.1    Pena, L.2    Perez-Alenza, M.D.3
  • 32
    • 3042767906 scopus 로고    scopus 로고
    • E-cadherin expression in canine mammary carcinomas with regional lymph node metastases
    • Brunetti B, Sarli G, Preziosi R, et al. E-cadherin expression in canine mammary carcinomas with regional lymph node metastases. J Vet Med A Physiol Pathol Clin Med 2003;50:496-500.
    • (2003) J Vet Med A Physiol Pathol Clin Med , vol.50 , pp. 496-500
    • Brunetti, B.1    Sarli, G.2    Preziosi, R.3
  • 33
    • 0015755362 scopus 로고
    • Canine malignant mammary tumors. 3. Special types of carcinomas, malignant mixed tumors
    • Misdorp W, Cotchin E, Hampe JF, et al. Canine malignant mammary tumors. 3. Special types of carcinomas, malignant mixed tumors. Vet Pathol 1973;10:241-256.
    • (1973) Vet Pathol , vol.10 , pp. 241-256
    • Misdorp, W.1    Cotchin, E.2    Hampe, J.F.3
  • 34
    • 0015196211 scopus 로고
    • Canine malignant mammary tumours. I. Sarcomas
    • Misdorp W, Cotchin E, Hampe JF, et al. Canine malignant mammary tumours. I. Sarcomas. Vet Pathol 1971;8:99-117.
    • (1971) Vet Pathol , vol.8 , pp. 99-117
    • Misdorp, W.1    Cotchin, E.2    Hampe, J.F.3
  • 35
    • 0015479187 scopus 로고
    • Canine malignant mammary tumors. 2. Adenocarcinomas, solid carcinomas and spindle cell carcinomas
    • Misdorp W. Canine malignant mammary tumors. 2. Adenocarcinomas, solid carcinomas and spindle cell carcinomas. Vet Pathol 1972;9:447-470.
    • (1972) Vet Pathol , vol.9 , pp. 447-470
    • Misdorp, W.1
  • 36
    • 0027163108 scopus 로고
    • A rapid and versatile method to synthesize internal standards for competitive PCR
    • Celi FS, Zenilman ME, Shuldiner AR. A rapid and versatile method to synthesize internal standards for competitive PCR. Nucleic Acids Res 1993;21:1047.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1047
    • Celi, F.S.1    Zenilman, M.E.2    Shuldiner, A.R.3
  • 37
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-362.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 38
    • 14444269482 scopus 로고    scopus 로고
    • MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
    • Teng DH, Hu R, Lin H, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 1997; 57:5221-5225.
    • (1997) Cancer Res , vol.57 , pp. 5221-5225
    • Teng, D.H.1    Hu, R.2    Lin, H.3
  • 39
    • 0034576144 scopus 로고    scopus 로고
    • Alternative splicing of the human PTEN/MMAC1/TEP1 gene
    • Sharrard RM, Maitland NJ. Alternative splicing of the human PTEN/MMAC1/TEP1 gene. Biochim Biophys Acta 2000;1494:282-285.
    • (2000) Biochim Biophys Acta , vol.1494 , pp. 282-285
    • Sharrard, R.M.1    Maitland, N.J.2
  • 40
    • 13444280433 scopus 로고    scopus 로고
    • SpliceInfo: An information repository for mRNA alternative splicing in human genome
    • Huang DH. SpliceInfo: an information repository for mRNA alternative splicing in human genome. Nucleic Acids Res 2005; 33:D80-D85.
    • (2005) Nucleic Acids Res , vol.33
    • Huang, D.H.1
  • 41
    • 0031594259 scopus 로고    scopus 로고
    • Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce Ehlers-Danlos syndrome type I
    • Michalickova K, Susie M, Willing MC, et al. Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce Ehlers-Danlos syndrome type I. Hum Mol Genet 1998;7:249-255.
    • (1998) Hum Mol Genet , vol.7 , pp. 249-255
    • Michalickova, K.1    Susie, M.2    Willing, M.C.3
  • 42
    • 0031458795 scopus 로고    scopus 로고
    • Byers pH. Splicing defects in the COL3A1 gene: Marked preference for 5′ (donor) spice-site mutations in patients with exon-skipping mutations and Ehlers-Danlos syndrome type IV
    • Schwarze U, Goldstein JA, Byers pH. Splicing defects in the COL3A1 gene: marked preference for 5′ (donor) spice-site mutations in patients with exon-skipping mutations and Ehlers-Danlos syndrome type IV. Am J Hum Genet 1997;61:1276-1286.
    • (1997) Am J Hum Genet , vol.61 , pp. 1276-1286
    • Schwarze, U.1    Goldstein, J.A.2
  • 43
    • 0033621042 scopus 로고    scopus 로고
    • The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
    • Georgescu MM, Kirsch KH, Akagi T, et al. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A 1999;96:10182-10187.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10182-10187
    • Georgescu, M.M.1    Kirsch, K.H.2    Akagi, T.3
  • 44
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • Lee JO, Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999;99:323-334.
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3
  • 45
    • 0031933599 scopus 로고    scopus 로고
    • Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers
    • Ueda K, Nishijima M, Inui H, et al. Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. Jpn J Cancer Res 1998;89:17-21.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 17-21
    • Ueda, K.1    Nishijima, M.2    Inui, H.3
  • 46
    • 0025355882 scopus 로고
    • Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction
    • Gilliland G, Perrin S, Blanchard K, et al. Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci U S A 1990; 87:2725-2729.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 2725-2729
    • Gilliland, G.1    Perrin, S.2    Blanchard, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.