The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: The role of Aβ1-42

Journal of Neurochemistry

Volumn 78, Issue 2, 2001, Pages 413-416

  Lauderback, Christopher M ^a   Hackett, Janna M ^a   Huang, Feng F ^b   Keller, Jeffrey N ^b   Szweda, Luke I ^c   Markesbery, William R ^a,b   Allan Butterfield, D ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 Hydroxy 2 nonenal; Alzheimer's disease; Beta amyloid; Excitotoxicity; GLT 1; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; AMYLOID BETA PROTEIN; GLIAL GLUTAMATE TRANSPORTER GLT 1; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BRAIN SYNAPTOSOME; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; LIPID PEROXIDATION; NEUROTOXICITY; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; WESTERN BLOTTING;

AGED; ALDEHYDES; AMINO ACID TRANSPORT SYSTEM X-AG; AMYLOID BETA-PROTEIN; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN; CEREBRAL CORTEX; CROSS-LINKING REAGENTS; FEMALE; GLUTAMIC ACID; HUMANS; MALE; NEUROGLIA; ORGAN SIZE; OXIDATION-REDUCTION; PARIETAL LOBE; PEPTIDE FRAGMENTS; RATS; REFERENCE VALUES; SYNAPTOSOMES;

EID: 0034925118     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00451.x     Document Type: Article

References (41)

1. Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
2. 4-Hydroxy-nonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes
3. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex
4. Beta-amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
5. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
6. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures
7. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation
8. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
9. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
10. Apoliprotein E knock-out synaptosomes are vulnerable to Aβ (1-40)-induced oxidative injury
11. Characterization of striatal lesions produced by glutamate uptake alteration: Cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expression
12. The role of excitotoxicity in ALS - What is the evidence?
13. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
14. Glutamate transporters in neurologic disease
15. P. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
16. Oxidative stress hypothesis in Alzheimer's disease
17. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
18. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
19. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo
20. Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice
21. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
22. Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism
23. J. Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE Genotype
24. Diagnostic criteria for the neuropathological assessment of Alzheimer's disease
25. Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease
26. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
27. Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures
28. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex
29. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
30. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
31. Amyloid β-protein and the genetics of Alzheimer's disease
32. The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins
33. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
34. Peroxynitrite inhibits glutamate transporter subtypes
35. Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism
36. Glutamate transporters are oxidant-vulnerable. A molecular link between oxidative and excitotoxic neurodegeneration?
37. Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes
38. Review. Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity
39. Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's Aβ (1-42) and (25-35)
40. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
41. Vitamin E prevents Alzheimer's amyloid -peptide (1-42)-induced protein oxidation and reactive oxygen species formation