Characterization of the inactivation of rat fatty acid synthase by C75: Inhibition of partial reactions and protection by substrates

Biochemical Journal

Volumn 388, Issue 3, 2005, Pages 895-903

  Rendina, Alan R ^a   Cheng, Dong ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

C75; Fatty acid synthase; Mechanism of inactivation; Obesity

Indexed keywords

BIOCHEMISTRY; CHARACTERIZATION; CHEMICAL MODIFICATION; COMPLEXATION; DISEASES; ENZYME INHIBITION; FATTY ACIDS; SUBSTRATES; TUMORS;

CERULENIN; DITHIOTHREITOL; FATTY ACID SYNTHASE (FAS); ROOM TEMPERATURE;

ENZYMES;

ACETYL COENZYME A; BETA KETOACYL SYNTHASE; C75; CERULENIN; CYSTEINE; DITHIOTHREITOL; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MALONYL COENZYME A; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SYNTHETASE; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SUBSTRATE; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE;

4-BUTYROLACTONE; ACETYL COENZYME A; ALCOHOL OXIDOREDUCTASES; ANIMALS; BINDING, COMPETITIVE; DITHIOTHREITOL; ENZYME ACTIVATION; FATTY ACID SYNTHETASE COMPLEX; KINETICS; LIVER; MALONYL COENZYME A; NADP; RATS; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 21744439458     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041963     Document Type: Article

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