Novel inhibitors of the condensing enzymes of the Type II fatty acid synthase of pea (Pisum sativum)

Biochemical Journal

Volumn 347, Issue 1, 2000, Pages 205-209

  Jones, A Lesley ^a   Herbert, Derek ^a   Rutter, Andrew J ^a   Dancer, Jane E ^b   Harwood, John L ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b AgrEvo UK Limited   (United Kingdom)

Author keywords

Plant fatty acid synthesis; Thiolactomycin analogues

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; CARBON 14; CITRATE SYNTHASE; FATTY ACID SYNTHASE; HYDROCARBON; LAURIC ACID; THIOLACTOMYCIN;

ARTICLE; CHLOROPLAST; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; NONHUMAN; PEA; PLANT LEAF; PRIORITY JOURNAL;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; CHLOROPLASTS; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; PEAS; PLANT LEAVES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EMBRYOPHYTA; ESCHERICHIA COLI; PISUM SATIVUM; SATIVUM;

EID: 0034176221     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470205     Document Type: Article

References (29)

1. 1 Harwood, J. L. (1996) Biochim. Biophys, Acta 1301, 7-56
2. 2 Shimakata, T. and Stumpf, P. K. (1982) Proc. Natl. Acad. Sci., U.S.A. 79, 5808-5812
3. 3 Shimakata, T. and Stumpf, P. K. (1983) Arch. Biochem. Biophys. 220, 39-45
4. 4 Hoj, P. B. and Mikkelsen, J. D. (1982) Carlsberg Res. Commun. 47, 119-141
5. 5 Schuz, R., Ebel, J. and Hahlbrock, K. (1982) FEBS Lett. 140, 207-209
6. 6 Harwood, J. L. (1988) Annu. Rev. Plant Physiol. Plant Mol. Biol. 39, 101-138
7. 7 Stumpf, P. L. and Shimaka, T. (1983) in Biosynthesis and Function of Plant Lipids (Thomson, W. W., Mudd, J. B. and Gibbs, M., eds.), pp. 1-16, Waverly Press, Baltimore
8. 8 Jackowski, S. and Rock, C. O. (1987) J. Biol. Chem. 262, 7927-7931
9. 9 Jaworski, J. G., Clough, R. C. and Barnum, S. R. (1989) Plant Physiol. 90, 41-44
10. 10 Jaworski, J. G., Clough, R. C., Barnum, S. R., Post-Beittenmiller, D. and Ohlrogge, J. B. (1990) in Plant Lipid Biochemistry, Structure and Utilization (Quinn, P. J. and Harwood, J. L., eds.), pp. 97-104, Portland Press Ltd., London
11. 11 Walsh, M. C., Kloptenstein, W. E. and Harwood, J. L. (1990) Phytochemistry 29, 3797-3799
12. 12 Nishida, I., Kawaguchi, A. and Yamada, M. (1984) Plant Cell Physiology 25, 265-268
13. 13 Nishida, I., Kawaguchi, A. and Yamada, M. (1986) J. Biochem. (Tokyo) 99, 1447-1454
14. 14 Gulliver, B. S. and Slabas, A. R. (1994) Plant Mol. Biol. 25, 179-191
15. 15 Jones, A. L., Dancer, J. E. and Harwood, J. L. (1995) Phytochemistry 39, 511-514
16. 16 Waller, R. F., Keeling, P. J., Donald, R. G. K., Striepen, B., Handman, E., Lang-Unnasch, N., Cowman, A. F., Besra, G. S., Roos, D. S. and McFadden, G. I. (1998) Proc. Natl. Acad. Sci., U.S.A. 95, 12352-12357
17. 17 Wang, C-L. J. and Salvino, J. M. (1984) Tetrahedron Lett. 25, 5243-5246
18. 18 Majerus, P. W., Alberts, A. W. and Vagelos, P. R. (1969) Methods Enzymol. 14, 43-50
19. 19 Rock, C. O. and Cronan, J. E. (1981) Methods Enzymol. 71, 163-168
20. 20 Rock, C. O., Garwin, J. L. and Cronan, J. E. (1981) Methods Enzymol. 71, 397-403
21. 21 Mills, W. R. and Joy, K. W. (1980) Planta 148, 75-83
22. 22 Walker, K. W. and Harwood, J. L. (1985) Biochem. J. 226, 551-556
23. 23 Arnon, D. I. (1949) Plant Physiol. 24, 1-15
24. 24 Jones, A. L., Dancer, J. E. and Harwood, J. L. (1994) Biochem. Soc. Trans. 22, 258S
25. 25 Smith, K. L., Douce, R. and Harwood, J. L. (1982) Phytochemistry 21, 569-573
26. 26 Garbus, J., De Luca, H. F., Loomans, M. E. and Strong, F. M. (1963) J. Biol. Chem. 238, 59-63
27. 27 Verwoert, I. I. G. S., Verbree, E. C., van der Linden, K. H., Nijkamp, H. J. J. and Stuije, A. R. (1992) J. Bacteriol. 174, 2851-2857
28. 28 Cho, S. H. and Thompson, G. A. (1987) in The Metabolism, Structure and Function of Plant Lipids (Stumpf, P. K., Mudd, J. B. and Nes, W. D., eds.), pp. 623-629, Plenum Press, New York
29. 29 Moche, M., Schneider, G., Edwards, P., Dekesh, K. and Lindqvist, Y. (1999) J. Biol. Chem. 274, 6031-6034