Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: An ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice

Brain Research

Volumn 1075, Issue 1, 2006, Pages 68-80

  Bian, Feng ^a   Li, Zheng ^a   Offord, James ^a   Davis, M Duff ^a,b   McCormick, Julie ^a   Taylor, Charles P ^a   Walker, Lary C ^a,c  

^a PFIZER INC   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Analgesic; Anatomy; Anticonvulsant; Anxiolytic; Mutant mice; Radioligand

Indexed keywords

BINDING PROTEIN; CALCIUM CHANNEL; GABAPENTIN; PREGABALIN; PROTEIN ALPHA 2 DELTA TYPE 1; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; CACNA2D1 PROTEIN, MOUSE; DRUG DERIVATIVE; PRIMER DNA;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG PROTEIN BINDING; HIPPOCAMPUS; MALE; MOUSE; MUTAGENESIS; NEOCORTEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPINAL CORD; AMINO ACID SUBSTITUTION; ANIMAL; CEREBELLUM; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

AMINO ACID SUBSTITUTION; AMYGDALA; ANIMALS; AUTORADIOGRAPHY; BASE SEQUENCE; CALCIUM CHANNELS; CEREBELLUM; DNA PRIMERS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEOCORTEX; POLYMERASE CHAIN REACTION; SPINAL CORD;

EID: 33644896021     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.12.084     Document Type: Article

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