Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat

Epilepsia

Volumn 44, Issue 7, 2003, Pages 893-903

  André, Véronique ^a   Rigoulot, Marie Aude ^a   Koning, Estelle ^a   Ferrandon, Arielle ^a   Nehlig, Astrid ^a  

^a INSERM   (France)

Author keywords

Long term exposure; Neuronal damage; Pregabalin; Spontaneous recurrent seizures; Temporal lobe epilepsy

Indexed keywords

LITHIUM; PILOCARPINE; PREGABALIN;

ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN PROTECTION; BRAIN REGION; CELL COUNT; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPTIC STATE; EPILEPTOGENESIS; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; LONG TERM CARE; MALE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; SEIZURE;

ANIMALS; ANTICONVULSANTS; ASTROCYTES; BRAIN; CELL DEATH; CEREBRAL CORTEX; CONVULSANTS; ELECTROENCEPHALOGRAPHY; ENTORHINAL CORTEX; EPILEPSY, TEMPORAL LOBE; GAMMA-AMINOBUTYRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IMMUNOENZYME TECHNIQUES; LITHIUM; NEUROPROTECTIVE AGENTS; PARAHIPPOCAMPAL GYRUS; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS;

EID: 0037478600     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.61802.x     Document Type: Article

References (55)

1. Cavalheiro EA, Leite JP, Bortolotto ZA, et al. Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 1991;32:778-82.
2. Dubé C, Boyet S, Marescaux C, et al. Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat. Exp Neurol 2001;167:227-41.
3. Leite JP, Bortolotto ZA, Cavalheiro EA. Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. Neurosci Biobehav Rev 1990;14:511-7.
4. Turski WA, Cavalheiro EA, Schwarz M, et al. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 1983;9:315-35.
5. McIntyre DC, Kelly ME. Pyriform cortex involvement in kindling. Neurosci Biobehav Rev 1989;13:277-80.
6. Du F, Eid T, Lothman EW, et al. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J Neurosci 1995;15:6301-13.
7. Miettinen R, Kotti T, Tuunanen J, et al. Hippocampal damage after injection of kainic acid into the rat entorhinal cortex. Brain Res 1998;813:9-17.
8. Scharfman HE. Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro. Neurophysiology 1996;76:2986-3001.
9. Scharfman HE, Goodman JH, Du F, et al. Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss. Neurophysiology 1998;80:3031-46.
10. Spiller AE, Racine RJ. Transfer kindling between sites in the entorhinal cortex-perforant path-dentate gyrus system. Brain Res 1994;635:130-8.
11. André V, Ferrandon A, Marescaux C, et al. The lesional and epileptogenic consequences of lithium-pilocarpine induced status epilepticus are affected by previous exposure to isolated seizures: effects of amygdala kindling and maximal electroshocks. Neuroscience 2000;99:469-81.
12. André V, Ferrandon A, Marescaux C, et al. Repeated electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. Epilepsy Res 2000;42:7-22.
13. André V, Ferrandon A, Marescaux C, et al. Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. Epilepsy Res 2001;47:99-117.
14. 3H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther 2000;295:1086-93.
15. Taylor CP, Vartanian MG. Profile of the anticonvulsant activity of CI-1008 (pregabalin) in animal models. Epilepsia 1997;38(suppl 8):35.
16. Abou-Khalil BW, Vazquez BR, Beydoun AA, et al. Pregabalin 7/8 study group, 1999: pregabalin in-patient monotherapy trial: study results and impact of seizure frequency on efficacy evaluations. Epilepsia 1999;40(suppl 7):109.
17. Bryans JS, Wustrow DJ. 3-Substituted GABA analogs with central nervous system activity: a review. Med Res Rev 1999;19:147-77.
18. Bialer M, Johannesen SI, Kupferberg HJ, et al. Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V). Epilepsy Res 2001;43:11-58.
19. 2δ subunit of a calcium channel. J Biol Chem 1996;271:5768-76.
20. Stephani A, Spadoni F, Bernardi G. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 1998;37:83-91.
21. +-induced synaptosomal calcium influx by gabapentin. Brain Res 2000;875:157-9.
22. Alden KJ, Garcia J. Differential effects of gabapentin on neuronal and muscle calcium currents. J Pharmacol Exp Ther 2001;297:727-35.
23. +-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin. Neurosci Lett 2000;280:107-10.
24. 3H] norepinephrine release from rat neocortical slices. Synapse 2002;45:171-90.
25. 2+ influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 2002;42:229-36.
26. Czuczwar SJ, Patsalos PN. The new generation of GABA enhancers: potential in the treatment of epilepsy. CNS Drugs 2001;15:339-50.
27. Whitworth TL, Quick MW. Upregulation of gamma-aminobutyric acid transporter expression: role of alkylated gamma-aminobutyric acid derivatives. Biochem Soc Trans 2001;29:736-41.
28. Sankar R, Shin DH, Liu H, et al. Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. J Neurosci 1998;18:8382-93.
29. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press, 1986.
30. Fernandes MJS, Boyet S, Marescaux C, et al. Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium-pilocarpine in immature and adult rats. J Cereb Blood Flow Metab 1999;19:195-209.
31. Motte J, Fernandes MJS, Baram TZ, et al. Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. Brain Res 1998;793:61-72.
32. Schachter SC. Current evidence that antiepileptic drugs are antiictal, not antiepileptogenic. Epilepsy Res 2002;50:67-70.
33. Pitkanen A. Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. Epilepsy Res 2002;50:141-60.
34. Valdizan EM, Garcia AP, Armijo JA. Time course of the GABAergic effects of vigabatrin: is the time course of brain GABA related to platelet GABA-transaminase inhibition? Epilepsia 1999;40:1062-9.
35. Welty D, Wang Y, Busch JA, et al. Pharmacokinetics (PK) and pharmacodynamics of CI-1008 (pregabalin) and gabapentin in rats with maximal electroshocks [Abstract]. Epilepsia 1997;38(suppl 8):35.
36. André V, Marescaux C, Nehlig A, et al. Alterations of the hippocampal GABAergic system contribute to the development of spontaneous recurrent seizures in the lithium-pilocarpine model of temporal lobe epilepsy. Hippocampus 2001;11:452-68.
37. Roch C, Leroy C, Nehlig A, et al. Contribution of magnetic resonance imaging to the study of the lithium-pilocarpine model of temporal lobe epilepsy in adult rats. Epilepsia 2002;43:325-35.
38. Witter MP. Organization of the entorhinal-hippocampal system: a review of current anatomical data. Hippocampus 1993;3:33-44.
39. Scharfman HE. Evidence from simultaneous intracellular recordings in rat hippocampal slices that are CA3 pyramidal cells innervate dentate hilar mossy cells. J Neurophysiol 1994;72:2167-80.
40. Bouilleret V, Ridoux V, Depaulis A, et al. Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: EEG, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 1999;89:717-29.
41. A-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus 2000;10:305-24.
42. Riban V, Bouilleret V, Pham-Lê BT, et al. Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy. Neuroscience 2002;112:101-11.
43. Sloviter RS. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 1994;35:640-54.
44. Dubé C, Boyet S, Marescaux C, et al. A metabolic and neuropathological approach to the understanding of plastic changes occurring in the immature and adult rat brain during lithium-pilocarpine induced epileptogenesis. Epilepsia 2000;41(suppl 6):S36-43.
45. Wall CJ, Kendall EJ, Obenaus A. Rapid alterations in diffusion-weighted images with anatomic correlates in a rodent model of status epilepticus. AJNR Am J Neuroradiol 2000;21:1841-52.
46. Roch C, Leroy C, Nehlig A, et al. Predictive value of cortical injury for the development of temporal lobe epilepsy in immature rats: an MRI approach using the lithium-pilocarpine model. Epilepsia 2002;43:1129-36.
47. Heinemann U, Beck H, Dreier JP, et al. The dentate gyrus as a regulated gate for the propagation of epileptiform activity. In: Ribak CE, Gall CM, Mody I, eds. The dentate gyrus and its role in seizures. Amsterdam: Elsevier Science, 1992:273-80.
48. Jones RS, Lambert JD. Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors. Neuroscience 1990;34:657-70.
49. McIntyre DC, Kelly ME. Are differences in dorsal hippocampal kindling related to amygdala-piriform area excitability? Epilepsy Res 1993;14:49-61.
50. Lindsay RM. Reactive gliosis. In: Fedoroff S, Vernadakis A, eds. Astrocytes. New York: Academic Press, 1986:231-62.
51. Hatten ME, Liem RKH, Shelanski ML, et al. Astroglia in CNS injury. Glia 1991;4:233-43.
52. Norton WT, Aquino DA, Hozumi I, et al. Quantitative aspects of reactive gliosis: a review. Neurochem Res 1992;17:877-85.
53. Castiglioni AJ, Peterson SL, Sanabria EL, et al. Structural changes in astrocytes induced by seizures in a mode of temporal lobe epilepsy. J Neurosci Res 1990;26:334-41.
54. Dusart I, Marty S, Peschanski M. Glial changes following an excitotoxic lesion in the CNS, II: Astrocytes. Neuroscience 1991;45:541-9.
55. Steward O, Torre ER, Tomasulo R, et al. Seizures and the regulation of astroglial gene expression. Epilepsy Res Suppl 1992;7:197-209.