Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 3, 2005, Pages 1406-1415

  Su, Ti Zhi ^a   Feng, M R ^a   Weber, M L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; AMINO ACID; CARRIER PROTEIN; GABAPENTIN; LEUCINE; PREGABALIN; PROTEIN GAT1; PROTEIN GAT2; PROTEIN GAT3; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CHO CELL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG TRANSPORT; DRUG UPTAKE; EPILEPSY; FIBROMYALGIA; GENERALIZED ANXIETY DISORDER; IN VIVO STUDY; MALE; MAMMAL CELL; NEUROPATHIC PAIN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

AMINO ACID TRANSPORT SYSTEM Y+; AMINO ACID TRANSPORT SYSTEMS; ANIMALS; ANTIGENS, CD98 LIGHT CHAINS; CACO-2 CELLS; CHO CELLS; CRICETINAE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MALE; MEMBRANE TRANSPORT PROTEINS; RATS; RATS, WISTAR;

EID: 19444375719     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.082255     Document Type: Article

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