Inhibition of neuronal Ca2+ influx by gabapentin and pregabalin in the human neocortex

Neuropharmacology

Volumn 42, Issue 2, 2002, Pages 229-236

  Fink, Klaus ^a   Dooley, David J ^b   Meder, Wolfgang P ^a,b   Suman Chauhan, Nirmala ^c   Duffy, Sandra ^c   Clusmann, Hans ^a   Göthert, Manfred ^a  

^a UNIVERSITY OF BONN   (Germany)

^b PFIZER INC   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

2 Subunits; Gabapentin; Human neocortex; P Q type voltage gated Ca2+ channels; Pregabalin; Synaptosomes

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; ASPARTIC ACID; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; EXCITATORY AMINO ACID; GABAPENTIN; GLUTAMIC ACID; NORADRENALIN; OMEGA AGATOXIN; POTASSIUM ION; PREGABALIN; PROTEIN SUBUNIT; TRITIUM;

ADOLESCENT; ADULT; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CHILD; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; ENANTIOMER; FEMALE; HUMAN; HUMAN TISSUE; IC 50; IMMUNOBLOTTING; ISOTOPE LABELING; MALE; MEMBRANE BINDING; NERVE ENDING; NORADRENALIN RELEASE; NORADRENERGIC NERVE; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL;

ACETIC ACIDS; ADOLESCENT; ADULT; AMINES; ANTICONVULSANTS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CHILD; CHILD, PRESCHOOL; CYCLOHEXANECARBOXYLIC ACIDS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; NEOCORTEX; NEURONS; NOREPINEPHRINE; OMEGA-AGATOXIN IVA; POTASSIUM; QUINOXALINES; RECEPTORS, AMPA; SYNAPTOSOMES;

EID: 0036166869     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00172-1     Document Type: Article

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