Structure-activity relationships of pregabalin and analogues that target the α2-δ protein

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2294-2307

  Belliotti, Thomas R ^a,d   Capiris, Thomas ^a   Ekhato, I Victor ^a,e   Kinsora, Jack J ^a   Field, Mark J ^b   Heffner, Thomas G ^c   Meltzer, Leonard T ^a   Schwarz, Jacob B ^a   Taylor, Charles P ^a   Thorpe, Andrew J ^a   Vartanian, Mark G ^a   Wise, Lawrence D ^a   Zhi Su, Ti ^a   Weber, Mark L ^a   Wustrow, David J ^a  

^a PFIZER INC   (United States)

^b Sandwich Laboratories   (United Kingdom)

^c Nagoya Laboratories   (Japan)

^d Kalexsyn Inc   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMINOMETHYL 5 DIMETHYLHEXANOIC ACID; GABAPENTIN; LEUCINE; PREGABALIN; PROTEIN; PROTEIN ALPHA2 DELTA; PROTEIN L; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BRAIN; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; SEIZURE; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

AMINES; AMINO ACID TRANSPORT SYSTEM L; ANALGESICS; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BRAIN; CALCIUM CHANNELS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; LEUCINE; MALE; MICE; MICE, INBRED DBA; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 20244384863     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049762l     Document Type: Article

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