Src activation is not necessary for transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells: PP1 directly inhibits TGF-β receptors I and II

Journal of Biological Chemistry

Volumn 281, Issue 1, 2006, Pages 59-68

  Maeda, Masato ^a   Shintani, Yasushi ^a   Wheelock, Margaret J ^a,b,c   Johnson, Keith R ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BIOASSAY; CELLS; ENZYME INHIBITION; PHYSIOLOGICAL MODELS;

CANCER PROGRESSION; EMBRYONIC DEVELOPMENT; EPITHELIAL TO MESENCHYMAL TRANSITIONS; KINASES; TRANSFORMING GROWTH FACTOR;

ONCOLOGY;

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; IMATINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; 4 AMINO 5 (4 METHYLPHENYL) 7 (TERT BUTYL)PYRAZOLO(3,4 D)PYRIMIDINE; 4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO(3,4-D)PYRIMIDINE; ABELSON KINASE; ACTIVIN RECEPTOR 1; INDOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMAD PROTEIN; SULFONAMIDE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MESENCHYME; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; MESODERM; METABOLISM; MOUSE; PHOSPHORYLATION; UDDER;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; INDOLES; MAMMARY GLANDS, ANIMAL; MESODERM; MICE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRAZOLES; PYRIMIDINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEINS; SRC-FAMILY KINASES; SULFONAMIDES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33644849647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M503304200     Document Type: Article

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