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Volumn 176, Issue 6, 2006, Pages 3652-3661

Modification of MyD88 mRNA splicing and inhibition of IL-1β signaling in cell culture and in mice with a 2′-O-methoxyethyl-modified oligonucleotide

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; OLIGONUCLEOTIDE;

EID: 33644847417     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.6.3652     Document Type: Article
Times cited : (52)

References (52)
  • 2
    • 0031423761 scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche, H., W. J. Henzel, W. Shillinglaw, S. Li, and Z. Cao. 1977. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7: 837-847.
    • (1977) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 4
    • 0029761275 scopus 로고    scopus 로고
    • TRAF6 is a signal transducer for interleukin-1
    • Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goedde. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383: 443-446.
    • (1996) Nature , vol.383 , pp. 443-446
    • Cao, Z.1    Xiong, J.2    Takeuchi, M.3    Kurama, T.4    Goedde, D.V.5
  • 5
    • 0034699340 scopus 로고    scopus 로고
    • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
    • Schnare, M., A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2000. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 10: 1139-1142.
    • (2000) Curr. Biol. , vol.10 , pp. 1139-1142
    • Schnare, M.1    Holt, A.C.2    Takeda, K.3    Akira, S.4    Medzhitov, R.5
  • 7
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 10
    • 0037105549 scopus 로고    scopus 로고
    • Cutting edge: Myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection
    • Weighardt, H., S. Kaiser-Moore, R. M. Vabulas, C. J. Kirschning, H. Wagner, and B. Holzmann. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J. Immunol. 169: 2823-2827.
    • (2002) J. Immunol. , vol.169 , pp. 2823-2827
    • Weighardt, H.1    Kaiser-Moore, S.2    Vabulas, R.M.3    Kirschning, C.J.4    Wagner, H.5    Holzmann, B.6
  • 11
    • 0036006290 scopus 로고    scopus 로고
    • Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88
    • Janssens, S., K. Burns, J. Tschopp, R. Beyaert. 2002. Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88. Curr. Biol. 12: 467-471.
    • (2002) Curr. Biol. , vol.12 , pp. 467-471
    • Janssens, S.1    Burns, K.2    Tschopp, J.3    Beyaert, R.4
  • 13
    • 0037454946 scopus 로고    scopus 로고
    • Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    • Burns, K., S. Janssens, B. Brissoni, N. Olivos, R. Beyaert, and J. Tschopp. 2003. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197: 263-268.
    • (2003) J. Exp. Med. , vol.197 , pp. 263-268
    • Burns, K.1    Janssens, S.2    Brissoni, B.3    Olivos, N.4    Beyaert, R.5    Tschopp, J.6
  • 14
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteome expansion in metazoans
    • Maniatis, T., and B. Tasic. 2002. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418: 236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 16
    • 8144225362 scopus 로고    scopus 로고
    • Variation in sequence and organization of splicing regulatory elements in vertebrate genes
    • Yeo, G., S. Hoon, B. Venkatesh, and C. B. Burge. 2004. Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc. Natl. Acad. Sci. USA 101: 15700-15705.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15700-15705
    • Yeo, G.1    Hoon, S.2    Venkatesh, B.3    Burge, C.B.4
  • 17
    • 0141497030 scopus 로고    scopus 로고
    • Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
    • Sazani, P., and R. Kole. 2003. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J. Clin. Invest. 112: 481-486.
    • (2003) J. Clin. Invest. , vol.112 , pp. 481-486
    • Sazani, P.1    Kole, R.2
  • 18
    • 0003826861 scopus 로고    scopus 로고
    • S through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides
    • S through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides. Nat. Biotech. 17: 1097-1100.
    • (1999) Nat. Biotech. , vol.17 , pp. 1097-1100
    • Taylor, J.K.1    Zhang, Q.Q.2    Wyatt, J.R.3    Dean, N.M.4
  • 20
    • 0033555551 scopus 로고    scopus 로고
    • Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression
    • McKay, R. A., L. J. Miraglia, L. L. Cummins, S. R. Owens, H. Sasmor, and N. M. Dean. 1999. Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression. J. Biol. Chem. 274: 1715-1722.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1715-1722
    • McKay, R.A.1    Miraglia, L.J.2    Cummins, L.L.3    Owens, S.R.4    Sasmor, H.5    Dean, N.M.6
  • 22
    • 0033916608 scopus 로고    scopus 로고
    • Deletion of individual exons and induction of soluble murine interleukin-5 receptor α chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing
    • Karras, J. G., R. A. McKay, N. M. Dean, and B. P. Monia. 2000. Deletion of individual exons and induction of soluble murine interleukin-5 receptor α chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing. Mol. Pharm. 58: 380-387.
    • (2000) Mol. Pharm. , vol.58 , pp. 380-387
    • Karras, J.G.1    McKay, R.A.2    Dean, N.M.3    Monia, B.P.4
  • 23
    • 0032700656 scopus 로고    scopus 로고
    • Molecular mechanisms of action of antisense drugs
    • Crooke, S. T. 1999. Molecular mechanisms of action of antisense drugs. Biochim. Biophys. Acta 1489: 30-42.
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 30-42
    • Crooke, S.T.1
  • 24
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 25
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen, N. J., S. Parrish, F. Imani, A. Fire, and R. A. Morgan. 2001. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. USA 98: 9742-9747.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 26
    • 0031010177 scopus 로고    scopus 로고
    • 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
    • Baker, B. F., S. S. Lot, T. P. Condon, S. Cheng-Floumoy, E. A. Lesnik, H. M. Sasmor, and C. F. Bennett. 1997. 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J. Biol. Chem. 272: 11994-12000.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11994-12000
    • Baker, B.F.1    Lot, S.S.2    Condon, T.P.3    Cheng-Floumoy, S.4    Lesnik, E.A.5    Sasmor, H.M.6    Bennett, C.F.7
  • 27
    • 0037320451 scopus 로고    scopus 로고
    • TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon- induction
    • Oshiumi, H., K. Funami, T. Akazawa, and T. Seya. 2003. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon- induction. Nat. Immunol. 4: 161-167.
    • (2003) Nat. Immunol. , vol.4 , pp. 161-167
    • Oshiumi, H.1    Funami, K.2    Akazawa, T.3    Seya, T.4
  • 28
    • 0026052924 scopus 로고
    • Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms
    • Chiang, M.-Y., H. Chan, M. A. Zounes, S. M. Freier, W. F. Lima, and C. F. Bennett. 1991. Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J. Biol. Chem. 266: 18162-18171.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18162-18171
    • Chiang, M.-Y.1    Chan, H.2    Zounes, M.A.3    Freier, S.M.4    Lima, W.F.5    Bennett, C.F.6
  • 29
    • 0034653783 scopus 로고    scopus 로고
    • Effects of RNA secondary structure on cellular antisense activity
    • Vickers, T. A., J. R. Wyatt, and S. M. Freier. 2000. Effects of RNA secondary structure on cellular antisense activity. Nucleic Acids Res. 28: 1340-1347.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 1340-1347
    • Vickers, T.A.1    Wyatt, J.R.2    Freier, S.M.3
  • 30
    • 0033574789 scopus 로고    scopus 로고
    • Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
    • Laroia, G., G. Brewer, and R. J. Schneider. 1999. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. Science 284: 499-502.
    • (1999) Science , vol.284 , pp. 499-502
    • Laroia, G.1    Brewer, G.2    Schneider, R.J.3
  • 31
    • 0033562350 scopus 로고    scopus 로고
    • Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro
    • Winer, J., C. Kwang, S. Jung, I. Shackel, and P. M. Williams. 1999. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 270: 41-49.
    • (1999) Anal. Biochem. , vol.270 , pp. 41-49
    • Winer, J.1    Kwang, C.2    Jung, S.3    Shackel, I.4    Williams, P.M.5
  • 33
    • 0030839546 scopus 로고    scopus 로고
    • Identification and characterization of second-generation antisense oligonucleotides
    • Dean, N. M., and R. H. Griffey. 1997. Identification and characterization of second-generation antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 7: 229-233.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 229-233
    • Dean, N.M.1    Griffey, R.H.2
  • 35
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346: 425-434.
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 38
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 39
    • 0036569028 scopus 로고    scopus 로고
    • Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 MAPK signal pathways
    • An, H., H. Xu, Y. Yu, M. Zhan, R. Qi, X. Yan, S. Liu, W. Wang, Z. Guo, Z. Qin, and X. Cao. 2002. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 MAPK signal pathways. Immunol. Lett. 81: 165-169.
    • (2002) Immunol. Lett. , vol.81 , pp. 165-169
    • An, H.1    Xu, H.2    Yu, Y.3    Zhan, M.4    Qi, R.5    Yan, X.6    Liu, S.7    Wang, W.8    Guo, Z.9    Qin, Z.10    Cao, X.11
  • 40
    • 0034602150 scopus 로고    scopus 로고
    • Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF-κB and expression of the inducible cyclooxygenase
    • Rhee, S. H., and D. Hwang. 2000. Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF-κB and expression of the inducible cyclooxygenase. J. Biol. Chem. 275: 34035-34040.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34035-34040
    • Rhee, S.H.1    Hwang, D.2
  • 42
    • 0036337915 scopus 로고    scopus 로고
    • A genomic view of alternative splicing
    • Modrek, B., and C. Lee. 2001. A genomic view of alternative splicing. Nat. Genet. 30: 13-19.
    • (2001) Nat. Genet. , vol.30 , pp. 13-19
    • Modrek, B.1    Lee, C.2
  • 43
    • 0037443035 scopus 로고    scopus 로고
    • Pre-mRNA splicing and human disease
    • Faustino, N. A., and T. A. Cooper. 2003. Pre-mRNA splicing and human disease. Genes. Dev. 17: 419-437.
    • (2003) Genes. Dev. , vol.17 , pp. 419-437
    • Faustino, N.A.1    Cooper, T.A.2
  • 44
    • 0030000245 scopus 로고    scopus 로고
    • Progress in antisense oligonucleotide therapeutics
    • Crooke, S. T., and C. F. Bennett. 1996. Progress in antisense oligonucleotide therapeutics. Ann. Rev. Pharm. Tox. 36: 107-129.
    • (1996) Ann. Rev. Pharm. Tox. , vol.36 , pp. 107-129
    • Crooke, S.T.1    Bennett, C.F.2
  • 45
    • 0036899212 scopus 로고    scopus 로고
    • RNAi and related mechanisms and their potential use for therapy
    • Agami, R. 2002. RNAi and related mechanisms and their potential use for therapy. Curr. Opin. Chem. Biol. 6: 829-834.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 829-834
    • Agami, R.1
  • 46
    • 0032729689 scopus 로고    scopus 로고
    • Predicting oligonucleotide affinity to nucleic acid targets
    • Mathews, D. H., M. E. Burkard, S. M. Freier, J. R. Wyatt, and D. H. Turner. 1999. Predicting oligonucleotide affinity to nucleic acid targets. RNA 5: 1458-1469.
    • (1999) RNA , vol.5 , pp. 1458-1469
    • Mathews, D.H.1    Burkard, M.E.2    Freier, S.M.3    Wyatt, J.R.4    Turner, D.H.5
  • 47
    • 0033891369 scopus 로고    scopus 로고
    • Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
    • Zhang, H., J. Cook, J. Nickel, R. Yu, K. Stecker, K. Myers, and N. M. Dean. 2000. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat. Biotech. 18: 862-867.
    • (2000) Nat. Biotech. , vol.18 , pp. 862-867
    • Zhang, H.1    Cook, J.2    Nickel, J.3    Yu, R.4    Stecker, K.5    Myers, K.6    Dean, N.M.7
  • 49
    • 0028062847 scopus 로고
    • Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides
    • Dean, N. M., and R. McKay. 1994. Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 91: 11762-11766.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11762-11766
    • Dean, N.M.1    McKay, R.2
  • 52
    • 0742323558 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics
    • Maquat, L. E. 2004. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat. Rev. Mol. Cell Biol. 5: 89-99.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 89-99
    • Maquat, L.E.1


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