The immediate-early gene product Egr-1 regulates the human interleukin- 2 receptor β-chain promoter through noncanonical Egr and Sp1 binding sites

Molecular and Cellular Biology

Volumn 17, Issue 7, 1997, Pages 3714-3722

  Lin, Jian Xin ^a   Leonard, Warren J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR SP1;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; IMMUNOREGULATION; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0030982768     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.7.3714     Document Type: Article

References (52)

1. Baeuerle, P.A. 1991 The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63-80.
2. Baldwin, A. S. 1987. Methylation interference assay for analysis of DNA-protein interactions, p. 12.2.1-12.2.4. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
3. Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4940-4944.
4. Begley, C. G., J. D. Burton, M. Tsudo, B. H. Brownstein, J. L. J. Ambrus, and T. A. Waldmann. 1990. Human B lymphocytes express the p75 component of the interleukin 2 receptor. Leuk. Res. 14:263-271.
5. Cao, X. M., R. A. Koski, A. Gashler, M. McKiernan, C. F. Morris, R. Gaffney, R. V. Hay, and V. P. Sukhatme. 1990. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol. Cell. Biol. 10:1931-1939.
6. Casey, L. S., A. H. Lichtman, and M. Boothby. 1992. IL-4 induces IL-2 receptor p75 β-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J. Immunol. 148:3418-3426.
7. Cerdan, C., Y. Martin, M. Courcoul, C. Mawas, F. Birg, and D. Olive. 1995. CD28 costimulation up-regulates long-term IL-2R β expression in human T cells through combined transcriptional and post-transcriptional regulation. J. Immunol. 154:1007-1013.
8. Christy, B., and D. Nathans. 1989. Functional serum response elements upstream of the growth factor-inducible gene zif268. Mol. Cell. Biol. 9:4889-4895.
9. Christy, B. A., L. F. Lau, and D. Nathans. 1988. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc. Natl. Acad. Sci. USA 85:7857-7861.
10. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045-1083.
11. Djeu, J. Y., J. H. Liu, S. Wei, H. Rui, C. A. Pearson, W. J. Leonard, and D. K. Blanchard. 1993. Function associated with IL-2 receptor-β on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2. J. Immunol. 150:960-970.
12. Dukovich, M., Y. Wano, L. thi Bich Thuy, P. Katz, B. R. Cullen, J. H. Kehrl, and W. C. Greene. 1987. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 327: 518-522.
13. Dynan, W. S., and R. Tjian. 1983. Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II. Cell 32:669-680.
14. Espinoza-Delgado, I., J. R. Ortaldo, R. Winkler-Pickett, K. Sugamura, L. Varesio, and D. L. Longo. 1990. Expression and role of p75 interleukin 2 receptor on human monocytes. J. Exp. Med. 171:1821-1826.
15. Gashler, A., and V. P. Sukhatme. 1995. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 50:191-224.
16. Gashler, A. L., S. Swaminathan, and V. P. Sukhatme. 1993. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediaie-early transcription factor Egr-1. Mol. Cell. Biol. 13:4556-4571.
17. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822-2830.
18. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
19. Hagen, G., S. Muller, M. Beato, and G. Suske. 1992. Cloning by recognition site screening of two novel GT box binding proteins: a family of Spl related genes. Nucleic Acids Res. 20:5519-5525.
20. Hatakeyama, M., M. Tsudo, S. Minamoto, T. Kono, T. Doi, T. Miyata, M. Miyasaka, and T. Taniguchi. 1989. Interleukin-2 receptor β chain gene: generation of three receptor forms by cloned human α and β chain cDNA's. Science 244:551-556.
21. Huang, L. M., and K.-T. Jeang. 1993. Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function. J. Virol. 67:6937-6944.
22. Jeang, K.-T., R. Chun, N. H. Lin, A. Gatignol, C. G. Glabe, and H. Fan. 1993. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J. Virol. 67:6224-6233.
23. Kharbanda, S., T. Nakamura, R. Stone, R. Hass, S. Bernstein, R. Datta, V. P. Sukhatme, and D. Kufe. 1991. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. J. Clin. Invest. 88:571-577.
24. Kharbanda, S., E. Rubin, R. Datta, R. Hass, V. Sukhatme, and D. Kufe. 1993. Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid. Cell Growth Differ. 4:17-23.
25. Kingsley, C., and A. Winoto. 1992. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12:4251-4261.
26. Lai, J.-S., and W. Herr. 1992. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc. Natl. Acad. Sci. USA 89:6958-6992.
27. Lau, L. F., and D. Nathans. 1987. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc. Natl. Acad. Sci. USA 84:1182-1186.
28. Leonard, W. J. 1994. The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy. Curr. Opin. Immunol. 6:631-635.
29. Li, R., J. D. Knight, S. P. Jackson, R. Tjian, and M. R. Botchan. 1991. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell 65:493-505.
30. Lin, J.-X., N. K. Bhat, S. John, W. S. Queale, and W. J. Leonard. 1993. Characterization of the human interleukin-2 receptor β-chain gene promoter: regulation of promoter activity by ets gene products. Mol. Cell. Biol. 13:6201-6210.
31. Maniatis, T., S. Goodbourn, and J. A. Fischer. 1987. Regulation of inducible and tissue-specific gene expression. Science 236:1237-1245.
32. Munoz, E., and A. Israel. 1995. Activation of NF-κB by the Tax protein of HTLV-1. Immunobiology 193:128-136.
33. Nguyen, H. Q., B. Hoffman-Liebermann, and D. A. Liebermann. 1993. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197-209.
34. Perkins, N. D., A. B. Agranoff, E. Pascal, and G. J. Nabel. 1994. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol. Cell. Biol. 14:6570-6583.
35. Rao, A. 1994. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol. Today 15:274-281.
36. Seyfert, V. L., V. P. Sukhatme, and J. G. Monroe. 1989. Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes. Mol. Cell. Biol. 9:2083-2088.
37. Sharon, M., J. R. Gnarra, and W. J. Leonard. 1990. A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the α and β chains. Proc. Natl. Acad. Sci. USA 87:4869-1873.
38. Siegel, J. P., M. Sharon, P. L. Smith, and W. J. Leonard. 1987. The IL-2 receptor β chain (p70): role in mediating signals for LAK, NK, and proliferative activities. Science 238:75-78.
39. Skerka, C., E. L. Decker, and P. F. Zipfel. 1995. A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1. J. Biol. Chem. 270:22500-22506.
40. Starkey, P. M. 1991. Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins. Immunology 73:64-70.
41. Su, W., S. Jackson, R. Tjian, and H. Echols. 1991. DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1. Genes Dev. 5:820-826.
42. Sugamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo, M. Nakamura, and T. Takeshita. 1996. The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 14:179-205.
43. Sukhatme, V. P., S. Kartha, F. G. Toback, R. Taub, R. G. Hoover, and C. H. Tsai-Morris. 1987. A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res. 1:343-355.
44. Sukhatme, V. P., X. M. Cao, L. C. Chang, C. H. Tsai-Morris, D. Stamenkovich, P. C. Ferreira, D. R. Cohen, S. A. Edwards, T. B. Shows, T. Curran, M. Le Beau, and E. Adamson. 1988. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37-43.
45. Suzuki, H., T. M. Kundig, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J. J. Simard, P. S. Ohashi, H. Griesser, T. Taniguchi, C. J. Paige, and T. W. Mak. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268:1472-1476.
46. Tanaka, T., Y. Takeuchi, T. Shiohara, F. Kitamura, Y. Nagasaka, K. Hamamura, H. Yagita, and M. Miyasaka. 1992. In utero treatment with monoclonal antibody to IL-2 receptor β-chain completely abrogates development of Thy-1+ dendritic epidermal cells. Int. Immunol. 4:487-491.
47. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-255.
48. Tjian, R., and T. Maniatis. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5-8.
49. Udvadia, A. J., K. T. Rogers, P. D. Higgins, Y. Murata, K. H. Martin, P. A. Humphrey, and J. M. Horowitz. 1993. Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression. Proc. Natl. Acad. Sci. USA 90:3265-3269.
50. Wei, S., D. K. Blanchard, J. H. Liu, W. J. Leonard, and J. Y. Djeu. 1993. Activation of tumor necrosis factor-α production from human neutrophils by IL-2 via IL-2-Rβ. J. Immunol. 150:1979-1987.
51. Yoshida, M., T. Suzuki, J. Fujisawa, and H. Hirai. 1995. HTLV-1 oncoprotein tax and cellular transcription factors. Curr. Top. Microbiol. Immunol. 193:79-89.
52. Zola, H., H. Weedon, G. R. Thompson, M. C. Fung, E. Ingley, and A. J. Hapel. 1991. Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation. Immunology 72:167-173.