메뉴 건너뛰기




Volumn 26, Issue 6, 2006, Pages 2146-2159

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; PROTEIN SUBUNIT; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 33644774920     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.26.6.2146-2159.2006     Document Type: Article
Times cited : (18)

References (69)
  • 1
    • 0037040990 scopus 로고    scopus 로고
    • Two independent regions of human tetomerase reverse transcriptase are important for its oligomerization and telomerase activity
    • Arai, K., K. Masutomi, S. Khurts, S. Kaneko, K. Kobayashi, and S. Murakami. 2002. Two independent regions of human tetomerase reverse transcriptase are important for its oligomerization and telomerase activity. J. Biol. Chem. 277:8538-8544.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8538-8544
    • Arai, K.1    Masutomi, K.2    Khurts, S.3    Kaneko, S.4    Kobayashi, K.5    Murakami, S.6
  • 2
    • 0034775749 scopus 로고    scopus 로고
    • N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
    • Armbruster, B. N., S. S. Banik, C. Guo, A. C. Smith, and C. M. Counter. 2001. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol. Cell. Biol. 21:7775-7786.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7775-7786
    • Armbruster, B.N.1    Banik, S.S.2    Guo, C.3    Smith, A.C.4    Counter, C.M.5
  • 3
    • 0037404425 scopus 로고    scopus 로고
    • Putative telomere-recruiting domain in the catalytic subunit of human telomerase
    • Armbruster, B. N., K. T. Etheridge, D. Broccoli, and C. M. Counter. 2003. Putative telomere-recruiting domain in the catalytic subunit of human telomerase. Mol. Cell. Biol. 23:3237-3246.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3237-3246
    • Armbruster, B.N.1    Etheridge, K.T.2    Broccoli, D.3    Counter, C.M.4
  • 5
    • 0035137710 scopus 로고    scopus 로고
    • Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
    • Bachand, F., and C. Autexier. 2001. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell. Biol. 21:1888-1897.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1888-1897
    • Bachand, F.1    Autexier, C.2
  • 6
    • 0035881160 scopus 로고    scopus 로고
    • Human telomerase RNA-protein interactions
    • Bachand, F., I. Triki, and C. Autexier. 2001. Human telomerase RNA-protein interactions. Nucleic Acids Res. 29:3385-3393.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3385-3393
    • Bachand, F.1    Triki, I.2    Autexier, C.3
  • 8
    • 0035723994 scopus 로고    scopus 로고
    • Functional multimerization of the human telomerase reverse transcriptase
    • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2001. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:6151-6160.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6151-6160
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 9
    • 0033790120 scopus 로고    scopus 로고
    • Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11:3329-3340.
    • (2000) Mol. Biol. Cell , vol.11 , pp. 3329-3340
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 10
  • 11
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106:661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 12
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn, E. H. 2000. Telomere states and cell fates. Nature 408:53-56.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 14
    • 0035861582 scopus 로고    scopus 로고
    • Quantitation of the RNA polymerase II transcription machinery in yeast
    • Borggrefe, T., R. Davis, A. Bareket-Samish, and R. D. Kornberg. 2001. Quantitation of the RNA polymerase II transcription machinery in yeast. J. Biol. Chem. 276:47150-47153.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47150-47153
    • Borggrefe, T.1    Davis, R.2    Bareket-Samish, A.3    Kornberg, R.D.4
  • 15
    • 0037439107 scopus 로고    scopus 로고
    • Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
    • Chen, J. L., and C. W. Greider. 2003. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22:304-314.
    • (2003) EMBO J. , vol.22 , pp. 304-314
    • Chen, J.L.1    Greider, C.W.2
  • 16
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., S. E. Artandi, Q. Shen, A. Tam, S. L. Lee, G. J. Gottlieb, C. W. Greider, and R. A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 17
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins, K., and J. R. Mitchell. 2002. Telomerase in the human organism. Oncogene 21:564-579.
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 18
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C. M., A. A. Avilion, C. E. LeFeuvre, N. G. Stewart, C. W. Greider, C. B. Harley, and S. Bacchetti. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 21
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. 2002. Protection of mammalian telomeres. Oncogene 21:532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 22
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange, T. 2005. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19:2100-2110.
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • De Lange, T.1
  • 23
    • 0033214013 scopus 로고    scopus 로고
    • Est1 and Cdc13 as comediators of telomerase access
    • Evans, S. K., and V. Lundblad. 1999. Est1 and Cdc13 as comediators of telomerase access. Science 286:117-120.
    • (1999) Science , vol.286 , pp. 117-120
    • Evans, S.K.1    Lundblad, V.2
  • 24
    • 0036362266 scopus 로고    scopus 로고
    • Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again
    • Forsyth, N. R., W. E. Wright, and J. W. Shay. 2002. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation 69:188-197.
    • (2002) Differentiation , vol.69 , pp. 188-197
    • Forsyth, N.R.1    Wright, W.E.2    Shay, J.W.3
  • 25
    • 0032699279 scopus 로고    scopus 로고
    • Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
    • Friedman, K. L., and T. R. Cech. 1999. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 13:2863-2874.
    • (1999) Genes Dev. , vol.13 , pp. 2863-2874
    • Friedman, K.L.1    Cech, T.R.2
  • 26
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 27
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
    • Hara, E., H. Tsurui, A. Shinozaki, S. Nakada, and K. Oda. 1991. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 179:528-534.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurui, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 28
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 29
    • 0030668722 scopus 로고    scopus 로고
    • Human telomerase contains evolutionarily conserved catalytic and structural subunits
    • Harrington, L. 1997. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 11:3109-3115.
    • (1997) Genes Dev. , vol.11 , pp. 3109-3115
    • Harrington, L.1
  • 31
    • 0037184040 scopus 로고    scopus 로고
    • Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative "thumb" domain
    • Hossain, S., S. Singh, and N. F. Lue. 2002. Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative "thumb" domain. J. Biol. Chem. 277:36174-36180.
    • (2002) J. Biol. Chem. , vol.277 , pp. 36174-36180
    • Hossain, S.1    Singh, S.2    Lue, N.F.3
  • 32
    • 0242286004 scopus 로고    scopus 로고
    • The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
    • Huard, S., T. J. Moriarty, and C. Autexier. 2003. The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Res. 31:4059-4070.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 4059-4070
    • Huard, S.1    Moriarty, T.J.2    Autexier, C.3
  • 33
    • 26444518182 scopus 로고    scopus 로고
    • Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase
    • Ji, H., M. H. Platts, L. M. Dharamsi, and K. L. Friedman. 2005. Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase. Mol. Cell. Biol. 25:9103-9114.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9103-9114
    • Ji, H.1    Platts, M.H.2    Dharamsi, L.M.3    Friedman, K.L.4
  • 35
    • 17044367499 scopus 로고    scopus 로고
    • Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT
    • Kim, J. H., S. M. Park, M. R. Kang, S. Y. Oh, T. H. Lee, M. T. Muller, and I. K. Chung. 2005. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Genes Dev. 19:776-781.
    • (2005) Genes Dev. , vol.19 , pp. 776-781
    • Kim, J.H.1    Park, S.M.2    Kang, M.R.3    Oh, S.Y.4    Lee, T.H.5    Muller, M.T.6    Chung, I.K.7
  • 38
    • 0035144580 scopus 로고    scopus 로고
    • RNA binding domain of telomerase reverse transcriptase
    • Lai, C. K., J. R. Mitchell, and K. Collins. 2001. RNA binding domain of telomerase reverse transcriptase. Mol. Cell. Biol. 21:990-1000.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 990-1000
    • Lai, C.K.1    Mitchell, J.R.2    Collins, K.3
  • 40
    • 0346101766 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate
    • Lee, S. R., J. M. Wong, and K. Collins. 2003. Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate. J. Biol. Chem. 278:52531-52536.
    • (2003) J. Biol. Chem. , vol.278 , pp. 52531-52536
    • Lee, S.R.1    Wong, J.M.2    Collins, K.3
  • 43
    • 0038188748 scopus 로고    scopus 로고
    • Telomere replication: An Est fest
    • Lundblad, V. 2003. Telomere replication: an Est fest. Curr. Biol. 13:R439-R441.
    • (2003) Curr. Biol. , vol.13
    • Lundblad, V.1
  • 44
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad, V., and J. W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 45
    • 0038305629 scopus 로고    scopus 로고
    • A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase
    • Ly, H., L. Xu, M. A. Rivera, T. G. Parslow, and E. H. Blackburn. 2003. A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev. 17:1078-1083.
    • (2003) Genes Dev. , vol.17 , pp. 1078-1083
    • Ly, H.1    Xu, L.2    Rivera, M.A.3    Parslow, T.G.4    Blackburn, E.H.5
  • 48
    • 0032961170 scopus 로고    scopus 로고
    • A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end
    • Mitchell, J. R., J. Cheng, and K. Collins. 1999. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19:567-576.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 567-576
    • Mitchell, J.R.1    Cheng, J.2    Collins, K.3
  • 49
    • 0033636897 scopus 로고    scopus 로고
    • Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    • Mitchell, J. R., and K. Collins. 2000. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6:361-371.
    • (2000) Mol. Cell , vol.6 , pp. 361-371
    • Mitchell, J.R.1    Collins, K.2
  • 50
    • 0036150238 scopus 로고    scopus 로고
    • Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit
    • Moriarty, T. J., S. Huard, S. Dupuis, and C. Autexier. 2002. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol. Cell. Biol. 22:1253-1265.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1253-1265
    • Moriarty, T.J.1    Huard, S.2    Dupuis, S.3    Autexier, C.4
  • 51
    • 1942453903 scopus 로고    scopus 로고
    • Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer
    • Moriarty, T. J., D. T. Marie-Egyptienne, and C. Autexier. 2004. Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. Mol. Cell. Biol. 24:3720-3733.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3720-3733
    • Moriarty, T.J.1    Marie-Egyptienne, D.T.2    Autexier, C.3
  • 52
    • 21844457135 scopus 로고    scopus 로고
    • An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization
    • Moriarty, T. J., R. J. Ward, M. A. Taboski, and C. Autexier. 2005. An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. Mol. Biol. Cell 16:3152-3161.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3152-3161
    • Moriarty, T.J.1    Ward, R.J.2    Taboski, M.A.3    Autexier, C.4
  • 53
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison, S. J., K. R. Prowse, P. Ho, and I. L. Weissman. 1996. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5:207-216.
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 55
    • 20444481334 scopus 로고    scopus 로고
    • Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA
    • O'Connor, C. M., C. K. Lai, and K. Collins. 2005. Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J. Biol. Chem. 280:17533-17539.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17533-17539
    • O'Connor, C.M.1    Lai, C.K.2    Collins, K.3
  • 56
    • 0034964393 scopus 로고    scopus 로고
    • Analysis of telomerase processivity: Mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance
    • Peng, Y., I. S. Mian, and N. F. Lue. 2001. Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance. Mol. Cell 7:1201-1211.
    • (2001) Mol. Cell , vol.7 , pp. 1201-1211
    • Peng, Y.1    Mian, I.S.2    Lue, N.F.3
  • 57
    • 0030781067 scopus 로고    scopus 로고
    • Functionally interacting telomerase RNAs in the yeast telomerase complex
    • Prescott, J., and E. H. Blackburn. 1997. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790-2800.
    • (1997) Genes Dev. , vol.11 , pp. 2790-2800
    • Prescott, J.1    Blackburn, E.H.2
  • 58
    • 0031029377 scopus 로고    scopus 로고
    • Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
    • Prescott, J., and E. H. Blackburn. 1997. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev. 11:528-540.
    • (1997) Genes Dev. , vol.11 , pp. 528-540
    • Prescott, J.1    Blackburn, E.H.2
  • 59
    • 0037381155 scopus 로고    scopus 로고
    • A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed
    • Reichenbach, P., M. Boss, C. M. Azzalin, M. Nabholz, P. Bucher, and J. Lingner. 2003. A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr. Biol. 13:568-574.
    • (2003) Curr. Biol. , vol.13 , pp. 568-574
    • Reichenbach, P.1    Boss, M.2    Azzalin, C.M.3    Nabholz, M.4    Bucher, P.5    Lingner, J.6
  • 60
    • 11144235139 scopus 로고    scopus 로고
    • Processive utilization of the human telomerase template: Lack of a requirement for template switching
    • Rivera, M. A., and E. H. Blackburn. 2004. Processive utilization of the human telomerase template: lack of a requirement for template switching. J. Biol. Chem. 279:53770-53781.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53770-53781
    • Rivera, M.A.1    Blackburn, E.H.2
  • 61
    • 0032532428 scopus 로고    scopus 로고
    • Specific telomerase RNA residues distant from the template are essential for telomerase function
    • Roy, J., T. B. Fulton, and E. H. Blackburn. 1998. Specific telomerase RNA residues distant from the template are essential for telomerase function. Genes Dev. 12:3286-3300.
    • (1998) Genes Dev. , vol.12 , pp. 3286-3300
    • Roy, J.1    Fulton, T.B.2    Blackburn, E.H.3
  • 62
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay, J. W., O. M. Pereira-Smith, and W. E. Wright. 1991. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196:33-39.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 64
    • 0037047643 scopus 로고    scopus 로고
    • Est1p as a cell cycle-regulated activator of telomere-bound telomerase
    • Taggart, A. K., S. C. Teng, and V. A. Zakian. 2002. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 297:1023-1026.
    • (2002) Science , vol.297 , pp. 1023-1026
    • Taggart, A.K.1    Teng, S.C.2    Zakian, V.A.3
  • 66
    • 0035796403 scopus 로고    scopus 로고
    • Human telomerase contains two cooperating telomerase RNA molecules
    • Wenz, C., B. Enenkel, M. Amacker, C. Kelleher, K. Damm, and J. Lingner. 2001. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20:3526-3534.
    • (2001) EMBO J. , vol.20 , pp. 3526-3534
    • Wenz, C.1    Enenkel, B.2    Amacker, M.3    Kelleher, C.4    Damm, K.5    Lingner, J.6
  • 67
    • 0033948026 scopus 로고    scopus 로고
    • Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
    • Xia, J., Y. Peng, I. S. Mian, and N. F. Lue. 2000. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol. Cell. Biol. 20:5196-5207.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5196-5207
    • Xia, J.1    Peng, Y.2    Mian, I.S.3    Lue, N.F.4
  • 68
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96:3723-3728.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.