Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 8, 2006, Pages 2837-2849

  Bulicz, Jacek ^a   Bertarelli, Daniela C G ^b   Baumert, Dieter ^b   Fülle, Friederike ^b   Müller, Christa E ^b   Heber, Dieter ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

A1 selectivity; Adenosine receptor antagonists; Gould Jacobs reaction; Inverse agonist; Pyrido 2,3 d pyrimidines; Structure activity relationships; Vilsmeier formylation

Indexed keywords

1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 (1 NAPHTHYL)AMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 (2 PHENYLPROPYL)AMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 MORPHOLINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 1,3 DIMETHYLURACIL DERIVATIVE; 5 AMINO 6 CYANO 1,2,3,4 TETRAHYDRO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 5 BENZYLAMINO 1,2,3,4 TETRAHYDRO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 5 BENZYLPIPERAZINO 1,2,3,4 TETRAHYDRO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 (2 NAPHTHYL) METHYLAMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 (2 NAPHTHYLMETHYL) AMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 7 (2 NAPHTHYL) METHYLAMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 7 (2 NAPHTHYLMETHYL) AMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 7 (4 NITROBENZYL) PIPERAZINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 5 (1 HYDROXY 1 PHENYLPROP 2 YL)AMINO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 1,2,3,4 TETRAHYDRO 5 [(1 HYDROXY 1 PHENYLPROP 2 YL)METHYL]AMINO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 7 BENZYLPIPERAZINO 1,2,3,4 TETRAHYDRO 1,3 DIMETHYLPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CARBETHOXY 7 CHLORO 1,3 DIMETHYL 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 CYANO 1,2,3,4 TETRAHYDRO 1,3 DIMETHYL 5 (2 PHENYLETHYL)AMINOPYRIDO[2,3 D]PYRIMIDINE 2,4 DIONE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; CARBONYL DERIVATIVE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KETONE DERIVATIVE; MALONIC ACID DERIVATIVE; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; RAT; SOLUBILITY; STRUCTURE ACTIVITY RELATION; VILSMEIER HAACK REACTION;

ANIMALS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; RATS; RECEPTORS, PURINERGIC P1; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CRICETULUS GRISEUS;

EID: 33644756543     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.008     Document Type: Article

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