N6,C8-disubstituted adenosine derivatives as partial agonists for adenosine A1 receptors

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1463-1471

  Roelen, Harlof ^a   Veldman, Nora ^b   Spek, Anthony L ^b   Von Frijtag Drabbe Künzel, Jacobien ^a   Mathôt, Ron A A ^a   Ijzerman, Ad P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE DERIVATIVE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE RECEPTOR; ANTIHYPERTENSIVE AGENT; DRUG DERIVATIVE; GUANOSINE TRIPHOSPHATE; N(6) ETHYL 8 (CYCLOPENTYLAMINO)ADENOSINE; N(6)-ETHYL-8-(CYCLOPENTYLAMINO)ADENOSINE; PHENETHYLAMINE DERIVATIVE; XANTHINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; HEART RATE; LIGAND BINDING; RECEPTOR BINDING; ANIMAL; BINDING COMPETITION; BLOOD PRESSURE; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; RAT; SYNTHESIS; WISTAR RAT; X RAY CRYSTALLOGRAPHY;

ADENOSINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BINDING, COMPETITIVE; BLOOD PRESSURE; BRAIN; CRYSTALLOGRAPHY, X-RAY; GUANOSINE TRIPHOSPHATE; HEART RATE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENETHYLAMINES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; XANTHINES;

EID: 0030605446     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950267m     Document Type: Article

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