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Volumn 49, Issue 8, 2001, Pages 988-998
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Design, synthesis and biological evaluation of a novel series of potent, orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability
a
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Author keywords
Adenosine A1 antagonist; Bioavailability; Blood brain barrier permeability; FR194921
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Indexed keywords
2 (1 METHYLPIPERIDIN 4 YL) 6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 3(2H) PYRIDAZINONE;
2 (2 HYDROXYPROPYL) 6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 3(2H) PYRIDAZINONE;
2 (2 OXOPROPYL) 6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 3(2H) PYRIDAZINONE;
2 (3 METHYL 2 OXOBUTYL) 6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 3(2H) PYRIDAZINONE;
6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 2 (2 PIPERIDIN 1 YL)ETHYL 3(2H) PYRIDAZINONE;
ADENOSINE A1 RECEPTOR ANTAGONIST;
N METHYL 2 [6 OXO 3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 1(6H) PYRIDAZIN 1 YL]ACETAMIDE;
UNCLASSIFIED DRUG;
ARTICLE;
BLOOD BRAIN BARRIER;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG BRAIN LEVEL;
DRUG DESIGN;
DRUG METABOLISM;
DRUG PENETRATION;
DRUG POTENCY;
DRUG RECEPTOR BINDING;
DRUG SELECTIVITY;
DRUG STABILITY;
DRUG SYNTHESIS;
ADMINISTRATION, ORAL;
ANIMALS;
BLOOD-BRAIN BARRIER;
BRAIN;
CAPILLARY PERMEABILITY;
CHO CELLS;
COS CELLS;
CRICETINAE;
DRUG EVALUATION, PRECLINICAL;
HUMANS;
LIVER;
MALE;
PYRIDINES;
RATS;
RATS, SPRAGUE-DAWLEY;
RECEPTORS, PURINERGIC P1;
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EID: 0034903373
PISSN: 00092363
EISSN: None
Source Type: Journal
DOI: 10.1248/cpb.49.988 Document Type: Article |
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Times cited : (27)
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References (34)
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