Toll-like receptor

Japanese Journal of Clinical Immunology

Volumn 28, Issue 5, 2005, Pages 309-317

  Takeda, Kiyoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

inflammatory bowel diseases; innate immunity; TIR domain; TLR

Indexed keywords

TOLL LIKE RECEPTOR;

ANIMAL; ENTERITIS; HUMAN; IMMUNOLOGY; MACROPHAGE; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; INFLAMMATORY BOWEL DISEASES; MACROPHAGES; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 33644700946     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.28.309     Document Type: Article

References (30)

1. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M. and Hoffmann J.A.: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973–983, 1996.
2. Medzhitov R., Preston-Hurlburt P. and Janeway C.A. Jr.: A human homlogue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394–397, 1997.
3. Takeda K., Kaisho T., Akira S.: Toll-like receptors. Annu Rev Immunol 21: 335–376, 2003.
4. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K and Akira S.: Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443–451, 1999.
5. Takeuchi O., Kawai T., Muhlradt P. F., Radolf J. D., Zychlinsky A., Takeda K. and Akira S.: Discrimination of bacterial lipopeptides by Tolllike receptor 6. Int Immunol 13: 933–940, 2001.
6. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., Modlin R.L. and Akira S.: Role of TLR1 in mediating immune response to microbial lipoproteins. J Immunol 169: 10–14, 2002.
7. Alexopoulou L., Holt A. C., Medzhitov R. and Flavell R.A.: Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732–738, 2001.
8. Poltorak A., He X., Smirnova I., Liu M. Y., Huffel C. V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B. and Beutler B.: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutation in Tlr4 gene. Science 282: 2085–2088, 1998.
9. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K. and Akira S.: Cutting Edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749–3752, 1999.
10. Hayashi F., Smith K. D., Ozinsky A., Hawn T. R., Yi E. C., Goodlett D. R., Eng J. K., Akira S., Underhill D.M. and Aderem A.: The innate immune response to bacterial flagellin is mediated by Toll-like receptor-5. Nature 410: 1099–1103, 2001.
11. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S.: Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303: 1526–1529, 2004.
12. Diebold S. S., Kaisho T., Hemmi H., Akira S., and Reis E., Sousa C.: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529–1531, 2004.
13. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo S., Hoshino K., Horiuchi T., Tomizawa H., Takeda K. and Akira S.: Antiviral low molecular weight compounds activate immune cells via TLR7 MyD88-dependent signalling pathway. Nature Immunol 3: 196–200, 2002.
14. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K. and Akira S.: A Toll-like receptor recognizes bacterial DNA. Nature 408: 740–745, 2000.
15. Takeda, K., and Akira, S.: Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499–511, 2004.
16. Suzuki N., Suzuki S., Duncan G. S., Millar D. G., Wada T., Mirtsos C., Takada H., Wakeham A., Itie A., Li S., Penninger J. M., Wesche H., Ohashi P. S., Mak T.W. and Yeh W.C.: Severe impairment of interleukinp1 and Toll-like receptor signalling in mice lacking IRAKp4. Nature 416: 750–756, 2002.
17. Picard C., Puel A., Bonnet M., Ku C. L., Bustamante J., Yang K., Soudais C., Dupuis S., Feinberg J., Fieschi C., Elbim C., Hitchcock R., Lammas D., Davies G., Al-Ghonaium A., Al-Rayes H., Al-Jumaah S., Al-Hajjar S., Al-Moh-sen I. Z., Frayha H. H., Rucker R., Hawn T. R., Aderem A., Tufenkeji H., Haraguchi S., Day N. K., Good R. A., Gougerot-Pocidalo M. A., Ozin-sky A. and Casanova J.L.: Pyogenic bacterial infections in humans with IRA κp4 deficiency. Science 299: 2076–2079, 2003.
18. Gohda J., Matsumura T. and Inoue J.: Cutting Edge: TNFR-associated factor 6 is essential for MyD88-dependent pathway but not Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β-dependent pathway in TLR signaling. J. Immunol. 173: 2913–2917, 2004.
19. Horng T., Barton G. M., Flavell R.A. and Medzhitov R.: The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors. Nature 420: 329–333, 2002.
20. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., Hoshino K., Takeuchi O., Kobayashi M., Fujita T., Takeda K. and Akira S.: Essential role of TIRAP for activation of the signaling cascade shared by TLR2 and TLR4. Nature 420: 324–329, 2002.
21. Kawai T., Adachi O., Ogawa T., Takeda K. and Akira S.: Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115–122, 1999.
22. Sharma S., tenOever B. R., Grandvaux N., Zhou G. P., Lin R. and Hiscott J.: Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148–1151, 2003.
23. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., Sugiyama M., Okabe M., Takeda K. and Akira S.: Role of adaptor TRIF in the MyD88-independent Tolllike receptor signaling pathway. Science 301: 640–643, 2003.
24. Hoebe K., Du X., Georgel P., Janssen E., Tabeta K., Kim S. O., Goode J., Li P., Mann N., Mudd S., Crozat K., Sovath S., Han J. and Beutler B.: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743–748, 2003.
25. Yamamoto M., Sato S., Hemmi H., Uematsu S., Hoshino K., Kaisho T., Takeuchi O., Takeda K. and Akira S.: TRAM is specifically involved in the TLR4-mediated MyD88-independent signaling pathway. Nat Immunol 4: 1144–1150, 2003.
26. Takeda, K. et al.: Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10: 39–49, 1999.
27. Kuhn R., Lohler J., Rennick D., Rajewsky K., and Muller W.: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263–274, 1993.
28. Kobayashi M., Kweon M., Kuwata H., Kiyono H., Takeda K., and Akira S.: Toll-like receptor-dependent IL-12p40 production causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111: 1297–1308, 2003.
29. Hirotani T., Lee P. Y., Kuwata H., Yamamoto M., Matsumoto M., Kawase I., Akira S., and Takeda K.: The nuclear IκB protein IκBNS selectively inhibits LPS-induced IL-6 production in macrophages of the colonic lamina propria. J. Immunol. 174: 3650–3657, 2005.
30. Kuwata H., Watanabe Y. Miyoshi H., Yamamoto M, Kaisho T., Takeda K., and Akira S.: IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages. Blood 102: 4123–4129, 2003.