Lethal giant puzzle of Lgl

Developmental Neuroscience

Volumn 28, Issue 1-2, 2006, Pages 13-24

  Vasioukhin, Valeri ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Cancer; Cell fate determination; Cell polarity; Lethal giant larvae; Notch

Indexed keywords

DISK PROTEIN; GENE PRODUCT; ISOPROTEIN; LETHAL GIANT LARVAE PROTEIN; NOTCH RECEPTOR; PROTEIN KINASE C; SCRIBBLE PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; BRAIN DEVELOPMENT; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIVISION; CELL FATE; CELL MUTANT; CELL POLARITY; CELL PROLIFERATION; DROSOPHILA; EUKARYOTE; EXOCYTOSIS; FUNCTIONAL PROTEOMICS; GENETIC CONSERVATION; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CELL POLARITY; CELL TRANSFORMATION, NEOPLASTIC; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, LETHAL; MICE; TUMOR SUPPRESSOR PROTEINS;

EID: 33644625714     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000090749     Document Type: Short Survey

References (72)

1. Agrawal N, Kango M, Mishra A, Sinha P (1995): Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal (2)giant larvae (lgl), a tumor suppressor gene of Drosophila. Dev Biol 172:218-229.
2. Albertson R, Doe CQ (2003): Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5:166-170.
3. Arquier N, Perrin L, Manfruelli P, Semeriva M (2001): The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal. Development 128:2209-2220.
4. Barros CS, Phelps CB, Brand AH (2003): Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev Cell 5:829-840.
5. Betschinger J, Eisenhaber F, Knoblich JA (2005): Phosphorylation-induced autoinhibition regulates the cytoskeletal protein lethal (2) giant larvae. Curr Biol 15:276-282.
6. Betschinger J, Knoblich JA (2004): Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol 14:R674-R685.
7. Betschinger J, Mechtler K, Knoblich JA (2003): The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 422:326-330.
8. Bilder D (2004): Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 18:1909-1925.
9. Bilder D, Li M, Perrimon N (2000): Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289:113-116.
10. Bilder D, Perrimon N (2000): Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403:676-680.
11. Bilder D, Schober M, Perrimon N (2003): Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol 5:53-58.
12. Brumby AM, Richardson HE (2003): Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22:5769-5779.
13. Castaneda-Castellanos DR, Kriegstein AR (2004): Controlling neuron number: does Numb do the math? Nat Neurosci 7:793-794.
14. De Lorenzo C, Mechler BM, Bryant PJ (1999): What is Drosophila telling us about cancer? Cancer Metastasis Rev 18:295-311.
15. Gaiano N, Nye JS, Fishell G (2000): Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 26:395-404.
16. Gateff E (1978): Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 200:1448-1459.
17. Gateff E, Schneiderman HA (1969): Neoplasms in mutant and cultured wild-type tissues of Drosophila. Natl Cancer Inst Monogr 31:365-397.
18. Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D (2004): The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 23:8688-8694.
19. Hadorn E (1938): Die Degeneration der Imaginalscheiben bei letalen Drosophila-Larven der Mutation Lethal-giant. Rev Suisse Zool 45:425-429.
20. Hsu SC, TerBush D, Abraham M, Guo W (2004): The exocyst complex in polarized exocytosis. Int Rev Cytol 233:243-265.
21. Humbert P, Russell S, Richardson H (2003): Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25:542-553.
22. Hutterer A, Betschinger J, Petronczki M, Knoblich JA (2004): Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell 6:845-854.
23. Justice NJ, Jan YN (2002): Variations on the Notch pathway in neural development. Curr Opin Neurobiol 12:64-70.
24. Kagami M, Toh-e A, Matsui Y (1998): Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function. Genetics 149:1717-1727.
25. Kim YK, Kim YS, Baek KH (2005): The WD-40 repeat motif of Lgl tumor suppressor proteins associated with salt tolerance and temperature sensitivity. Biochem Biophys Res Commun 331:922-928.
26. Kim YK, Kim YS, Chung HM, Baek KH (2004): Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes. Oncol Rep 12:1105-1108.
27. Kim YS, Chung HM, Baek KH (2003): WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not m-tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae. Int J Oncol 23:229-233.
28. Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V (2004): Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18:559-571.
29. Kloc M, Zearfoss NR, Etkin LD (2002): Mechanisms of subcellular mRNA localization. Cell 108:533-544.
30. Kosodo Y, Roper K, Haubensak W, Marzesco AM, Corbeil D, Huttner WB (2004): Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J 23:2314-2324.
31. Langevin J, Le Borgne R, Rosenfeld F, Gho M, Schweisguth F, Bellaiche Y (2005): Lethal giant larvae controls the localization of Notch-signaling regulators Numb, Neuralized, and Sanpodo in Drosophila sensory-organ precursor cells. Curr Biol 15:955-962.
32. Larsson K, Bohl F, Sjostrom I, Akhtar N, Strand D, Mechler BM, Grabowski R, Adler L (1998): The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene. J Biol Chem 273:33610-33618.
33. Lehman K, Rossi G, Adamo JE, Brennwald P (1999): Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol 146:125-140.
34. Li HS, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN (2003): Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105-1118.
35. Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S (2002): Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn 225:61-69.
36. McGill MA, McGlade CJ (2003): Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278:23196-23203.
37. Mechler BM, McGinnis W, Gehring WJ (1985): Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J 4:1551-1557.
38. Musch A, Cohen D, Yeaman C, Nelson WJ, Rodriguez-Boulan E, Brennwald PJ (2002): Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell 13:158-168.
39. Ohshiro T, Yagami T, Zhang C, Matsuzaki F (2000): Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408:593-596.
40. Pagliarini RA, Xu T (2003): A genetic screen in Drosophila for metastatic behavior. Science 302:1227-1231.
41. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP (2004): Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167:215-221.
42. Peng CY, Manning L, Albertson R, Doe CQ (2000): The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408:596-600.
43. Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W (2002): Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419:929-934.
44. Petersen PH, Zou K, Krauss S, Zhong W (2004): Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci 7:803-811.
45. Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN (2003): The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell 4:273-281.
46. Plant PJ, Fawcett JP, Lin DC, Holdorf AD, Binns K, Kulkarni S, Pawson T (2003): A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol 5:301-308.
47. Roegiers F, Jan YN (2004): Asymmetric cell division. Curr Opin Cell Biol 16:195-205.
48. Roegiers F, Jan LY, Jan YN (2005): Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell 16:3480-3487.
49. Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ (2003): Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol 163:1089-1098.
50. Sakisaka T, Baba T, Tanaka S, Izumi G, Yasumi M, Takai Y (2004): Regulation of SNAREs by tomosyn and ROCK: implication in extension and retraction of neurites. J Cell Biol 166:17-25.
51. Schimanski CC, Schmitz G, Kashyap A, Bosserhoff AK, Bataille F, Schafer SC, Lehr HA, Berger MR, Galle PR, Strand S, Strand D (2005): Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene 24:3100-3109.
52. Schweisguth F (2004): Notch signaling activity. Curr Biol 14:R129-R138.
53. Shen Q, Temple S (2002): Creating asymmetric cell divisions by skewing endocytosis. Sci STKE 2002:PE52.
54. Shen Q, Zhong W, Jan YN, Temple S (2002): Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 129:4843-4853.
55. Strand D (1998): The tumor suppressor l(2)gl; a myosin II-binding protein family; in Maruta H, Kohama K (eds): G Proteins, Cytoskeleton and Cancer. Molecular Biology Intelligence Unit 3. Georgetown, RG Landes, pp 61-78.
56. Strand D, Jakobs R, Merdes G, Neumann B, Kalmes A, Heid HW, Husmann I, Mechler BM (1994): The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain. J Cell Biol 127:1361-1373.
57. Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF, et al (1995): A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene 11:291-301.
58. Tanentzapf G, Tepass U (2003): Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat Cell Biol 5:46-52.
59. Tokunaga A, Kohyama J, Yoshida T, Nakao K, Sawamoto K, Okano H (2004): Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain. J Neurochem 90:142-154.
60. Tullio AN, Bridgman PC, Tresser NJ, Chan CC, Conti MA, Adelstein RS, Hara Y (2001): Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol 433:62-74.
61. Wadskog I, Maldener C, Proksch A, Madeo F, Adler L (2004): Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Mol Biol Cell 15:1436-1444.
62. Wodarz A, Huttner WB (2003): Asymmetric cell division during neurogenesis in Drosophila and vertebrates. Mech Dev 120:1297-1309.
63. Woodhouse EC, Fisher A, Bandle RW, Bryant-Greenwood B, Charboneau L, Petricoin EF 3rd, Liotta LA (2003): Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Proc Natl Acad Sci USA 100:11463-11468.
64. Woodhouse E, Hersperger E, Shearn A (1998): Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev Genes Evol 207:542-550.
65. Woods DF, Bryant PJ (1989): Molecular cloning of the lethal(1)discs large-1 oncogene of Drosophila. Dev Biol 134:222-235.
66. Woods DF, Bryant PJ (1991): The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66:451-464.
67. Woods DF, Wu JW, Bryant PJ (1997): Localization of proteins to the apico-lateral junctions of Drosophila epithelia. Dev Genet 20:111-118.
68. Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S (2003): Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol 13:734-743.
69. Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005): Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem 280:6761-6765.
70. Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K (2005): Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell 8:43-52.
71. Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN (1996): Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17:43-53.
72. Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN (1997): Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124:1887-1897.