Mechanisms of subcellular mRNA localization

Cell

Volumn 108, Issue 4, 2002, Pages 533-544

  Kloc, Malgorzata ^a   Zearfoss, N Ruth ^a   Etkin, Laurence D ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MESSENGER RNA; TRANS ACTING FACTOR;

AMINO ACID SEQUENCE; CELL MEMBRANE TRANSPORT; CELL TYPE; CELLULAR DISTRIBUTION; CYTOSKELETON; DROSOPHILA; GENE CONTROL; HUMAN; NERVE CELL PLASTICITY; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; RNA BINDING; RNA TRANSCRIPTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION INITIATION; XENOPUS; YEAST;

EID: 0037154985     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00651-7     Document Type: Review

References (92)

1. Dynamic visualization of local protein synthesis in hippocampal neurons
2. Transport and localization elements in myelin basic protein mRNA
3. Presence of mitochondria-type ribosomes outside mitochondria in germ plasm of Drosophila embryos
4. Role for mRNA localization in translational activation but not spatial restriction of nanos RNA
5. RNA localization in development
6. Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster
7. Neuronal RNA localization and the cytoskeleton
8. Recognition and long-range interactions of a minimal nanos RNA localization signal element
9. She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p
10. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts
11. Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis
12. VASA mediates translation through interaction with a Drosophila yIF2 homolog
13. Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
14. In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway
15. Fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes
16. The Drosophila CPEB homolog, orb, is required for oskar protein expression in oocytes
17. Structural elements required for the localization of ASH1 mRNA and of a green fluorescent protein reporter particle in vivo
18. RNP localization and transport in yeast
19. Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism
20. RNA localization and translational regulation during axis specification in the Drosophila oocyte
21. A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
22. Overlapping but distinct RNA elements control repression and activation of nanos translation
23. Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila
24. Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum
25. A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates
26. Dynamic Hsp83 RNA localization during Drosophila oogenesis and embryogenesis
27. Rab11 polarization of the Drosophila oocyte: A novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation
28. RNA-RNA interaction is required for the formation of specific bicoid mRNA 3′ UTR-STAUFEN ribonucleoprotein particles
29. A conserved 90 nucleotide element mediates translational repression of nanos RNA
30. ASH1 mRNA localization in yeast involves multiple secondary structural elements and Ash1 protein translation
31. CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division
32. Localization-dependent translation requires a functional interaction between the 5′ and 3′ ends of oskar mRNA
33. RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization
34. Vegetal localization of maternal mRNAs is disrupted by VegT depletion
35. Beta and gamma actin mRNAs are differentially located within myoblasts
36. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
37. An interaction type of genetic screen reveals a role of the Rab11 gene in oskar mRNA localization in the developing Drosophila melanogaster oocyte
38. mRNA localization: Message on the move
39. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
40. Molecular insights into mRNA transport and local translation in the mammalian nervous system
41. Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential
42. Polarizing genetic information in the egg: RNA localization in the frog oocyte
43. Isoform-specific 3′-untranslated sequences sort alpha-cardiac and beta-cytoplasmic actin messenger RNAs to different cytoplasmic compartments
44. Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA
45. The targeting of Xcat2 mRNA to the germinal granules depends on a cis-acting germinal granule localization element within the 3′ UTR
46. Mitochondrial ribosomal RNA in the germinal granules in Xenopus embryos revisited
47. RNA localization and germ cell determination in Xenopus
48. Three dimensional ultrastructural analysis of RNA distribution within germinal granules of Xenopus
49. Localization of mitochondrial large ribosomal RNA in germ plasm of Xenopus embryos
50. The cis-acting RNA trafficking signal from myelin basic protein mRNA and its cognate trans-acting ligand hnRNP A2 enhance cap-dependent translation
51. Translational regulation of oskar mRNA occurs independent of the cap and poly(A) tail in Drosophila ovarian extracts
52. Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation
53. Mechanisms of RNA localization and translational regulation
54. She2p is a novel RNA-binding protein that recruits the Myo4p-She3p complex to ASH1 mRNA
55. Xcat2 RNA is a translationally sequestered germ plasm component in Xenopus
56. Diversity in translational regulation
57. Mutational analysis of an RNA recognition element that mediates localization of bicoid mRNA
58. Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1
59. Bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery
60. Control of memory formation through regulated expression of a CaMKII transgene
61. Translational control by CPEB: A means to the end
62. Distinct roles of two conserved Staufen domains in oskar mRNA localization and translation
63. RNA sorting in Xenopus oocytes and embryos
64. Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis
65. A 250 nt UA-rich element in the 3′ untranslated region of Xenopus laevis Vg1 mRNA represses translation both in vivo a nd in vitro
66. Getting the message across: The intracellular localization of mRNAs in higher eukaryotes
67. Internal initiation of translation of five dendritically localized neuronal mRNAs
68. Think globally, translate locally: What mitotic spindles and neuronal synapses have in common
69. Staufen: A common component of mRNA transport in oocytes and neurons?
70. Characterization of a beta-actin mRNA zipcode-binding protein
71. Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C
72. Coordinate initiation of Drosophila development by regulated polyadenylation of maternal messenger RNAs
73. The role of oocyte transcription, the 5′UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization
74. A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 mRNA
75. The germline in C. elegans: Origins, proliferation, and silencing
76. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
77. Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro
78. Protein synthesis at synaptic sites on dendrites
79. A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites
80. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
81. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites
82. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p
83. Localization of gurken RNA in Drosophila oogenesis requires elements in the 5′ and 3′ regions of the transcript
84. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic axis formation
85. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes
86. Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles
87. CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses
88. Defining cis-acting elements and trans-acting factors in RNA localization
89. A two-step model for the localization of maternal mRNA in Xenopus oocytes: Involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA
90. Neurotrophin-induced transport of a beta-actin mRNP complex increases beta-actin levels and stimulates growth cone motility
91. A proline-rich protein binds to the localization element of Xenopus Vg1 mRNA and to ligands involved in actin polymerization
92. Localization of Xcat-2 RNA, a putative germ plasm component, to the mitochondrial cloud in Xenopus stage I oocytes