Hypoxia regulation of gene transcription

High Altitude Medicine and Biology

Volumn 2, Issue 2, 2001, Pages 145-154

  Caro, J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Erythropoietin; Gene regulation; HIF 1; Oxygen sensing; VEGF

Indexed keywords

GLYCOLYTIC ENZYME; GROWTH FACTOR; HEME; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; PROTEASOME; PROTEIN SUBUNIT; UBIQUITIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADAPTATION; ARTICLE; COMPLEX FORMATION; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; MODEL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; REGULATORY MECHANISM; SENSOR; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; DNA-BINDING PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NUCLEAR PROTEINS; RATS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034920196     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/152702901750265251     Document Type: Article

References (55)

1. Cellular oxygen sensors
2. An essential role for p300/CBP in the cellular response to hypoxia
3. Enhancer element at the 3′ flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
4. Characterization of hypoxia responsive enhancer in the human erythropoietin gene reveals presence of hypoxia inducible 120 kDa nuclear DNA-binding protein in erythropoietin producing and non-producing cells
5. Hypoxic induction of the human erythropoietin gene cooperation between the promoter and enhancer each of which contains steroid receptor response elements
6. Erythropoietin: A model system for studying oxygen-dependent gene regulation
7. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α
8. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor 1α during hypoxia
9. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
10. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
11. Molecular mechanisms of transcription activation by HLF and HIF-1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
12. Physiology of renal hypoxia
13. Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species
14. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes, similarities with the erythropoietin 3′ enhancer
15. Angiogenic Factors
16. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: Implications for the mechanism of oxygen sensing
17. Induction of hypoxia-inducible factor 1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for SRC kinase
18. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
19. Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF-3α
20. Molecular mechanism of HIF-1α-p300 interaction: A leucine-rich interface regulated by a single cysteine
21. Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis
22. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α-subunit
23. 2-dependent degradation domain via the ubiquitin-proteasome pathway
24. Induction of HIF-1α in response to hypoxia is instantaneous
25. 2 tension
26. Transactivation and inhibitory domains of hypoxia-inducible factor 1α: Modulation of transcriptional activity by oxygen tension
27. Functions of the von Hippel-Lindau tumour suppressor protein
28. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
29. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
30. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
31. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
32. The tumor suppressor protein VHL targets hypoxia inducible factors for oxygen-dependent proteolysis
33. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
34. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
35. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene
36. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
37. HIF-1α is required for solid tumor formation and embryonic vascularization
38. Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth
39. Complex role of protein phosphorylation in gene activation by hypoxia
40. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes
41. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure
42. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
43. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
44. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
45. Hypoxia inducible Factor 1α (HIF-1α) is a non-heme iron protein: Implications for oxygen sensing
46. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-α) proteins
47. Hypoxia-inducible factor 1α protein expression is controlled by oxygen regulated ubiquitination that is disrupted by deletions and missense mutations
48. Mechanism of regulation of the hypoxia-inducible factor-1α by the von hippel-lindau tumor suppressor protein
49. Endothelial PAS domain protein 1 (EPAS 1), a transcription factor selectively expressed in endothelial cells
50. Characterization of hypoxia-inducible factor 1 and regulation of DNA-binding activity by hypoxia
51. Purification and characterization of hypoxia-inducible factor 1
52. 2 tension
53. Mammalian oxygen sensing, signalling and gene regulation
54. HIF-1 and the molecular response to hypoxia in mammals
55. Loss of PTEN facilities HIF-1-mediated gene expression