-
1
-
-
0019979856
-
Thiolactomycin, a new antibiotic
-
Sakaki, H., Oishi, H., Hayashi, T., Matsuura, I., Ando, K. and Sawada, M. Thiolactomycin, a new antibiotic. J Antibiot 1982, 35: 396-400.
-
(1982)
J Antibiot
, vol.35
, pp. 396-400
-
-
Sakaki, H.1
Oishi, H.2
Hayashi, T.3
Matsuura, I.4
Ando, K.5
Sawada, M.6
-
2
-
-
0020324674
-
Thiolactomycin, a new antibiotic IV. Biological properties and chemotherapeutic activity in mice
-
Miyakawa, S., Suzuki, K., Noto, T., Harada, Y. and Okazaki, H. Thiolactomycin, a new antibiotic IV. Biological properties and chemotherapeutic activity in mice. J Antibiot 1982, 35: 411-9.
-
(1982)
J Antibiot
, vol.35
, pp. 411-419
-
-
Miyakawa, S.1
Suzuki, K.2
Noto, T.3
Harada, Y.4
Okazaki, H.5
-
3
-
-
0020525231
-
Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli
-
Hayahsi, T., Yamamoto, O., Sasaki, H., Kawaguchi, A. and Okazaki, H. Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli. Biochem Biophys Res Commun 1983, 115: 1108-13.
-
(1983)
Biochem Biophys Res Commun
, vol.115
, pp. 1108-1113
-
-
Hayahsi, T.1
Yamamoto, O.2
Sasaki, H.3
Kawaguchi, A.4
Okazaki, H.5
-
4
-
-
0036247948
-
Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics
-
Heath, R.J., White, S.W. and Rock, C.O. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Appl Microbiol Biotechnol 2002, 58: 695-703.
-
(2002)
Appl Microbiol Biotechnol
, vol.58
, pp. 695-703
-
-
Heath, R.J.1
White, S.W.2
Rock, C.O.3
-
5
-
-
0035338328
-
Bacterial fatty acid biosynthesis: A genomics driven target for antibacterial drug discovery
-
Payne, D.J., Warren, P.V., Holmes D.J., Ji, Y. and Lonsdale, J.T. Bacterial fatty acid biosynthesis: A genomics driven target for antibacterial drug discovery. Drug Discov Today 2001, 6: 537-44.
-
(2001)
Drug Discov Today
, vol.6
, pp. 537-544
-
-
Payne, D.J.1
Warren, P.V.2
Holmes, D.J.3
Ji, Y.4
Lonsdale, J.T.5
-
6
-
-
0029653518
-
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
-
Fleischmann, R.D., Adams, M.D., White, O. et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 1995, 269: 496-512.
-
(1995)
Science
, vol.269
, pp. 496-512
-
-
Fleischmann, R.D.1
Adams, M.D.2
White, O.3
-
7
-
-
0034644010
-
A triclosan-resistant bacterial enzyme
-
Heath, R.J. and Rock, C.O. A triclosan-resistant bacterial enzyme. Nature 2000, 406: 145.
-
(2000)
Nature
, vol.406
, pp. 145
-
-
Heath, R.J.1
Rock, C.O.2
-
8
-
-
0037444822
-
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK)
-
Marrakchi, H., Dewolf, W.E., Quinn, C. et al. Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK). Biochem J 2003, 15: 1055-62.
-
(2003)
Biochem J
, vol.15
, pp. 1055-1062
-
-
Marrakchi, H.1
Dewolf, W.E.2
Quinn, C.3
-
9
-
-
0030278374
-
Ambulatory patients with community-acquired pneumonia: The frequency of atypical agents and clinical course
-
Marrie, T.J., Peeling, R.W., Fine, M.J., Singer, D.E., Coley, C.M. and Kapoor, W.N. Ambulatory patients with community-acquired pneumonia: The frequency of atypical agents and clinical course. Am J Med 1996, 101: 508-15.
-
(1996)
Am J Med
, vol.101
, pp. 508-515
-
-
Marrie, T.J.1
Peeling, R.W.2
Fine, M.J.3
Singer, D.E.4
Coley, C.M.5
Kapoor, W.N.6
-
10
-
-
0035082407
-
Mycoplasma pneumoniae infections
-
Hammershlag, M. Mycoplasma pneumoniae infections. Curr Opin Infect Dis 2001, 14: 181-6.
-
(2001)
Curr Opin Infect Dis
, vol.14
, pp. 181-186
-
-
Hammershlag, M.1
-
11
-
-
0030940841
-
Animal fatty acid synthase: Functional mapping and cloning and expression of the domain I constituent activities
-
Chirala, S.S. et al. Animal fatty acid synthase: Functional mapping and cloning and expression of the domain I constituent activities. Proc Natl Acad Sci USA 1997, 94: 5588-93.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5588-5593
-
-
Chirala, S.S.1
-
12
-
-
6444245419
-
Novel antibacterials: A genomics approach to drug discovery
-
Chan, P., Macarron, R., Payne, D.J., Zalacain, M. and Holmes, D.J. Novel antibacterials: A genomics approach to drug discovery. Curr Drug Targets Infect Disord 2002, 2: 109-19.
-
(2002)
Curr Drug Targets Infect Disord
, vol.2
, pp. 109-119
-
-
Chan, P.1
Macarron, R.2
Payne, D.J.3
Zalacain, M.4
Holmes, D.J.5
-
13
-
-
2942703545
-
Validation of drug target by regulated antisense RNA in Staphylococcus aureus
-
Ji, Y., Broskey, J., Payne, D.J., Woodnutt, G., Rosenberg, M. and Burnham, M. Validation of drug target by regulated antisense RNA in Staphylococcus aureus. Am Soc Microbiol 2001.
-
(2001)
Am Soc Microbiol
-
-
Ji, Y.1
Broskey, J.2
Payne, D.J.3
Woodnutt, G.4
Rosenberg, M.5
Burnham, M.6
-
14
-
-
0033592365
-
Kinetic and structural characteristics of the inhibition of enoyl(acyl carrier protein) reductase by triclosan
-
Ward, W.H.J., Holdgate, G.A., Rowsell, S. et al. Kinetic and structural characteristics of the inhibition of enoyl(acyl carrier protein) reductase by triclosan. Biochemistry 1999, 38: 12514-25.
-
(1999)
Biochemistry
, vol.38
, pp. 12514-12525
-
-
Ward, W.H.J.1
Holdgate, G.A.2
Rowsell, S.3
-
15
-
-
0036783668
-
Discovery of a novel and potent class of Fab1 directed antibacterial agents
-
Payne, D.J., Miller, W.H., Berry, V. et al. Discovery of a novel and potent class of Fab1 directed antibacterial agents. Antimicrob Agents Chemother 2002, 46: 3118-24.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3118-3124
-
-
Payne, D.J.1
Miller, W.H.2
Berry, V.3
-
16
-
-
0037413576
-
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modelling
-
Daines, R.A., Pendrak, I., Sham, K. et al. First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modelling. J Med Chem 2003, 46: 5-8.
-
(2003)
J Med Chem
, vol.46
, pp. 5-8
-
-
Daines, R.A.1
Pendrak, I.2
Sham, K.3
-
17
-
-
0034660522
-
Development of a scintillation proximity assay for beta-ketoacyl carrier protein synthase III
-
He, X., Mueller, J.P. and Reynolds, K.A. Development of a scintillation proximity assay for beta-ketoacyl carrier protein synthase III. Anal Biochem 2000, 282: 107-14.
-
(2000)
Anal Biochem
, vol.282
, pp. 107-114
-
-
He, X.1
Mueller, J.P.2
Reynolds, K.A.3
-
18
-
-
0032515066
-
Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis
-
Heath, R.J., Yu, Y.-T., Shapiro, M.A., Olson, E. and Rock, C.O. Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis. J Biol Chem 1998, 273: 30316-20.
-
(1998)
J Biol Chem
, vol.273
, pp. 30316-30320
-
-
Heath, R.J.1
Yu, Y.-T.2
Shapiro, M.A.3
Olson, E.4
Rock, C.O.5
-
19
-
-
0032490937
-
Triclosan targets lipid synthesis
-
McMurry, L.M., Oethinger, M. and Levy, S.B. Triclosan targets lipid synthesis. Nature 1998, 394: 531-2.
-
(1998)
Nature
, vol.394
, pp. 531-532
-
-
McMurry, L.M.1
Oethinger, M.2
Levy, S.B.3
-
20
-
-
2942749778
-
A microtiter-based macromolecular synthesis assay for assessing the MOA (mode of action) of antibacterial agents against Gram-positive and Gram-negative pathogens
-
Orlando, Poster A-24
-
Greenwood, R.C., Nicholas, R.O., Nwanguma, N., VanAller, G.S., Payne, D.J. and Gentry, D. A microtiter-based macromolecular synthesis assay for assessing the MOA (mode of action) of antibacterial agents against Gram-positive and Gram-negative pathogens. Am Soc Microbiol 101st Gen Meet, Orlando 2001, Poster A-24.
-
(2001)
Am Soc Microbiol 101st Gen Meet
-
-
Greenwood, R.C.1
Nicholas, R.O.2
Nwanguma, N.3
VanAller, G.S.4
Payne, D.J.5
Gentry, D.6
-
21
-
-
17944376779
-
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
-
Heerding, D.A., Chan, G., Dewolf, W.E. et al. 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett 2001, 11: 2061-5.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 2061-2065
-
-
Heerding, D.A.1
Chan, G.2
Dewolf, W.E.3
-
22
-
-
17944379321
-
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-Di-substituted 1,2,3,4-tetrahydropyrido[3,4-b]-indoles as potential antibacterial agents
-
Seefeld, M.A., Miller, W.H., Newlander, K.A. et al. Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-Di-substituted 1,2,3,4-tetrahydropyrido[3,4-b]-indoles as potential antibacterial agents. Bioorg Med Chem Lett 2001, 17: 2241-4.
-
(2001)
Bioorg Med Chem Lett
, vol.17
, pp. 2241-2244
-
-
Seefeld, M.A.1
Miller, W.H.2
Newlander, K.A.3
-
23
-
-
0037130227
-
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)
-
Miller, W.H., Seefeld, M.A., Newlander, K.A. et al. Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J Med Chem 2002, 45: 3246-56.
-
(2002)
J Med Chem
, vol.45
, pp. 3246-3256
-
-
Miller, W.H.1
Seefeld, M.A.2
Newlander, K.A.3
-
24
-
-
0037464456
-
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
-
Seefeld, M.A., Miller, W.H., Newlander, K.A. et al. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem 2003, 46: 1627-35.
-
(2003)
J Med Chem
, vol.46
, pp. 1627-1635
-
-
Seefeld, M.A.1
Miller, W.H.2
Newlander, K.A.3
-
25
-
-
0036841782
-
Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus
-
Fan, F., Yan, K., Wallis, N.G. et al. Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus. Antimicrob Agents Chemother 2002, 46: 3343-7.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3343-3347
-
-
Fan, F.1
Yan, K.2
Wallis, N.G.3
-
27
-
-
0035139250
-
Current status of malaria and potential for control
-
Phillipps, R.S. Current status of malaria and potential for control. Clin Microbiol Rev 2001, 14: 208-26.
-
(2001)
Clin Microbiol Rev
, vol.14
, pp. 208-226
-
-
Phillipps, R.S.1
-
28
-
-
0142061141
-
Apicoplast fatty acid biosynthesis as a target for medical intervention in api-complexan parasites
-
Gornicki, P. Apicoplast fatty acid biosynthesis as a target for medical intervention in api-complexan parasites. Int J Parasitol 2003, 33: 885-96.
-
(2003)
Int J Parasitol
, vol.33
, pp. 885-896
-
-
Gornicki, P.1
-
29
-
-
0036232990
-
Purification, characterisation, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
-
He, X. and Reynolds, K.A. Purification, characterisation, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrob Agents Chemother 2002, 46: 1310-8.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1310-1318
-
-
He, X.1
Reynolds, K.A.2
-
30
-
-
0035839602
-
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
-
Khandekar, S.S., Gentry, D.R., Van Aller, G.S. et al. Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH). J Biol Chem 2001, 276: 30024-30.
-
(2001)
J Biol Chem
, vol.276
, pp. 30024-30030
-
-
Khandekar, S.S.1
Gentry, D.R.2
Van Aller, G.S.3
|