Intracellular pathways linking hypoxia to activation of c-fos and AP-1

Advances in Experimental Medicine and Biology

Volumn 475, Issue , 2000, Pages 101-109

  Premkumar, D R ^a   Adhikary, G ^a   Overholt, J L ^a   Simonson, M S ^a   Cherniack, N S ^a   Prabhakar, N R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; CIS ACTING ELEMENT; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; PROTEIN C FOS; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; BREATHING MUSCLE; CALCIUM CELL LEVEL; CHEMORECEPTOR; CONFERENCE PAPER; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPOXIA; NONHUMAN; OXYGEN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANOXIA; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CHANNELS; CELL HYPOXIA; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; GENES, FOS; GTP-BINDING PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TRANSCRIPTION FACTOR AP-1;

ANIMALIA;

EID: 0034464870     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (26)

1. Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells
2. Regulation, substrates and functions of src
3. Isolation and characterization of the c-fos (rat) cDNA and analysis of post translational modification in vitro
4. Calcium influx activates extracellular-regulated kinase/mitogen activated protein kinase pathway through a calmodulin sensitive mechanism in PC12 cells
5. Regulation of mitogen-activated protein kinases by calcium/calmodulin-dependent protein kinase cascade
6. Inhibition of NIH 3T3 cells proliferation by a mutant ras protein with preferential affinity for GDP
7. 2+-dependent routes to Ras: Mechanisms for neuronal survival, differentiation, and plasticity?
8. 2+ channel-regulated neuronal gene expression
9. Fos family members successively occupy the tyrosine hydroxylase gene AP-1 site after nerve growth factor or epidermal growth factor stimulation and can repress transcription
10. The N-methyl-D-aspartate receptor pathway is involved in hypoxia-induced c-fos protein expression in the rat nucleus of the solitary tract
11. Nuclear signalling by endothelin-1. A Ras pathway for activation of the c-fos serum response element
12. Release of dopamine and norepinephrine by hypoxia from PC12 cells
13. Calcium/calmodulin-dependent protein kinase type II and IV differentially regulate CREB-dependent gene expression
14. Histochemical staining of clonal mammalian cell lines expressing E. coli β-galactosidase indicates heterogeneous expression of the bacterial gene
15. Role of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydroxylase gene expression
16. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
17. Activation of cell specific expression of hormone and prolactin genes by a common transcription factor
18. Time domains of the hypoxic ventilatory response
19. Cell selective induction and transcriptional activation of immediate early genes by hypoxia
20. Src, a non-receptor tyrosine kinase is required for c-fos expression by hypoxia
21. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro
22. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases
23. Molecular cloning and expression of chicken C-terminal Src kinase: Lack of stable association with c-Src protein
24. Delayed expression of c-fos protein in rat hippocampus and cerebral cortex following transient in vivo exposure to hypoxia
25. The Src family tyrosine kinase are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells
26. 2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter