Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes

Blood

Volumn 88, Issue 2, 1996, Pages 417-428

  Li, Junzhi ^b   Avraham, Hava ^b   Rogers, Rick A ^b   Raja, Sandhya ^b   Avraham, Shalom ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; INTEGRIN; PHOSPHOTRANSFERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; MACROPHAGE ACTIVATION; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN;

EID: 0029978533     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.2.417.bloodjournal882417     Document Type: Article

References (35)

1. Gumbiner BM: Proteins associated with the cytoplasmic surface of adhesion molecules. Neuron 11:551, 1993
2. Albelda SM, Buck CA: Integrins and other cell adhesion molecules, FASEB J 4:2868, 1990
3. Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11, 1992
4. Burridge K, Fath KR, Kelly T, Nuckolls GH, Turner C: Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4:487, 1988
5. Turner CE, Burridge K: Transmembrane molecular assemblies in cell-extracellular matrix interactions. Curr Opin Cell Biol 3:849, 1991
6. Clark EA, Brugge JS: Integrins and signal transduction pathways: The road taken. Science 268:233, 1995
7. Richardson A, Parsons JT: Signal transduction through integrins: A central role for focal adhesion kinase. Bioessays 17:229, 1995
8. Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT: pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 89:5192, 1992
9. Hanks SK, Calalb MB, Harper MC, Patel SK: Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 89:8487, 1992
10. Burridge K, Turner CE, Romer LH: Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly. J Cell Biol 119:893, 1992
11. Chen H-C, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan J-L: Interaction of focal adhesion kinase with cytoskeletal protein talin. J Biol Chem 270:16995, 1995
12. Weng Z, Taylor JA, Turner CE, Brugge JS, Seidel-Dugan C: Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. J Biol Chem 268:14956, 1993
13. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT: Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14:1680, 1994
14. Cobb BS, Schaller MD, Leu T-H, Parsons JT: Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol 14:147, 1994
15. Eide BL, Turck CW, Escobedo JA: Identification of Tyr397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK. Mol Cell Biol 15:2819, 1995
16. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P: Integrin-mediated signal transduction linked to Ras pathway by Grb2 binding to focal adhesion kinase. Nature 372:786, 1994
17. Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D: Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin. Proc Natl Acad Sci USA 92:6132, 1995
18. Chen H-C, Guan J-L: Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 91:10148, 1994
19. Guinebault C, Payrastre B, Racaud-Sultan C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H: Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J Cell Biol 129:831, 1995
20. Zachary I, Sinnett-Smith J, Rozengurt E: Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. J Biol Chem 267:19031, 1992
21. Sinnett-Smith J, Zachary I, Valverde AM, Rozengurt E: Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. J Biol Chem 268:14261, 1993
22. FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells. J Biol Chem 269:24328, 1994
23. Zhang C, Lambert MP, Bunch C, Barber K, Wade WS, Krafft GA, Klein WL: Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. J Biol Chem 269:25247, 1994
24. FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence. J Biol Chem 268:6851, 1993
25. Matsumoto K, Matsumoto K, Nakamura T, Kramer RH: Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 269:31807, 1994
26. Rankin S, Rozengurt E: Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin. J Biol Chem 269:704, 1994
27. Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S, Pasztor LM, White RA, Groopman JE, Avraham H: Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem 270:27742, 1995
28. Sasaki H, Nagura K, Ishino M, Tobioka H, Kotani K, Sasaki T: Cloning and characterization of cell adhesion kinase β, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J Biol Chem 270:21206, 1995
29. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376:737, 1995
30. Sakaguchi M, Sato T, Groopman JE: Human immunodeficiency virus infection of megakaryocytic cells. Blood 77:481, 1991
31. Komatsu N, Suda T, Moroi M, Tokuyama N, Sakata Y, Okada M, Nishida T, Hirai Y, Sato T, Fuse A, Miura Y: Growth and differentiation of a human megakaryoblastic cell line, CMK. Blood 74:42, 1989
32. Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Handin RI: Characterization of a new megakaryocytic cell line: The Dami cells. Blood 72:1968, 1988
33. Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE: Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood 83:2126, 1994
34. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Schaffhausen B, Cantley LC: SH2 domains recognize specific phosphopeptide sequences. Cell 72:767, 1993
35. Chan PY, Kanner SB, Whitney G, Aruffo A: A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J Biol Chem 269:20567, 1994