Chronic hypoxia reduces adenosine A(2A) receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A

Journal of Physiology

Volumn 512, Issue 2, 1998, Pages 351-363

  Kobayashi, Shuichi ^a   Beitner Johnson, Dana ^a   Conforti, Laura ^a   Millhorn, David E ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 8 BROMO CYCLIC AMP; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; FURA 2; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; RADIOLIGAND; RECEPTOR SUBTYPE; ADENOSINE A1 RECEPTOR; ADENOSINE A3 RECEPTOR; CALCIUM CHANNEL; KEMPTIDE; POTASSIUM CHANNEL;

ANIMAL CELL; ANOXIA; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXCITABILITY; HYPOXIA; LIGAND BINDING; MEMBRANE; NEGATIVE FEEDBACK; NONHUMAN; NORTHERN BLOTTING; PATCH CLAMP; PRIORITY JOURNAL; RAT; ANIMAL TISSUE; CELL VIABILITY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; IMMUNOREACTIVITY; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; BLOTTING, NORTHERN; CALCIUM CHANNELS; CELL HYPOXIA; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FORSKOLIN; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PC12 CELLS; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032532183     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.351be.x     Document Type: Article

References (44)

1. ARCHER, S. L., HAMPL, V., NELSON, D. P., SIDNEY, E., PETERSON, D. A. & WEIR, E. K. (1995). Dithionate increases radical formation and decreases vasoconstriction in the lung: evidence that dithionate does not mimic alveolar hypoxia. Circulation Research 77, 174-181.
2. 2+/calmodulin signaling systems in PC12 cells. Biochemical and Biophysical Research Communications 241, 61-66.
3. BRADFORD, M. M. (1974). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248-254.
4. 2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells. Molecular Pharmacology 44, 950-958.
5. + channel in rat PC12 cells by hypoxia. Journal of Physiology 502, 293-305.
6. CZYZYK-KRZESKA, M. F., FURNARI, B. F., LAWSON, E. E. & MILLHORN, D. E. (1994). Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. Journal of Biological Chemistry 269, 760-764.
7. 2+ channels in the rat carotid body chemoreceptor type I cells. Journal of Physiology 489, 689-699.
8. 2 dopamine receptors in rat striatum. Molecular Brain Research 14, 186-195.
9. FREDHOLM, B. B. (1995). Purinoreceptors in the nervous system. Pharmacology and Toxicology 76, 228-239.
10. GLASS, D. B., LUNDQUIST, L. J., KATZ, B. M. & WALSH, D. A. (1989). Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase. Journal of Biological Chemistry 264, 14579-14584.
11. GONZALEZ, C., ALMARAZ, L., OBESO, A. & RIGUAL, R. (1994). Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiological Reviews 74, 829-898.
12. GREENE, L. A. & TISCHLER, A. S. (1976). Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proceedings of the National Academy of Sciences of the USA 73, 2424-2428.
13. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
14. HANBAUER, I. F., KAROUM, F., HELLSTROM, S. & LAHIRI, S. (1981). Effects of hypoxia lasting up to one month on the catecholamine content in rat carotid body. Neuroscience 6, 81-86.
15. HEMPLEMAN, S. C. (1995). Sodium and potassium current in neonatal rat carotid body cells following chronic in vivo hypoxia. Brain Research 699, 42-50.
16. HEMPLEMAN, S. C. (1996). Increased calcium current in carotid body glomus cells following in vivo acclimatization to chronic hypoxia. Journal of Neurophysiology 76, 1880-1886.
17. 2a adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. Molecular Pharmacology 41, 352-359.
18. HOCHACHKA, P. W., BUCK, L. T., DOLL, C. J. & LAND, S. C. (1996). Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proceedings of the National Academy of Sciences of the USA 93, 9493-9498.
19. 2+ channels by cAMP and cGMP in vascular smooth muscle cells. Circulation Research 73, 1128-1137.
20. 2 receptors in rat brain tissue. Journal of Pharmacology and Experimental Therapeutics 251, 47-55.
21. KACIMI, R., MOALIC, J. M., ALDASHEV, A., VATNER, D. E., RICHALET, J. P. & CROZATIER, B. (1995). Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia. American Journal of Physiology 269, H1865-1873.
22. 2A receptor. Journal of Physiology 508, 95-107.
23. KUSAKABE, T., POWELL, F. L. & ELLISMAN, M. H. (1993). Ultrastructure of the glomus cells in the carotid body of chronically hypoxic rats: with special reference to the similarity of amphibian glomus cells. Anatomical Records 237, 220-227.
24. s - requirement for multiple cytoplasmic domain in the coupling process. Journal of Biological Chemistry 266, 4816-4821.
25. MCQUEEN, D. S. (1993). Does adenosine stimulate rat carotid body chemoreceptors? In Neurobiology and Cell Physiology of Chemoreception, Advances in Experimental Medicine and Biology, ed. DATA, P. G., ACKER, H. & LAHIRI, S., pp. 289-293. Plenum Press, New York.
26. MCQUEEN, D. S. & RIBEIRO, J. A. (1986). Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine. British Journal of Pharmacology 88, 615-620.
27. MONTEIRO, E. C. & RIBEIRO, J. A. (1987). Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology 335, 143-148.
28. OLAH, M. E. & STILES, G. L. (1995). Adenosine receptor subtypes: characterization and therapeutic regulation. Annual Review of Pharmacology and Toxicology 35, 581-606.
29. PHILLIS, J. W., WALTER, G. A., O'REGAN, M. H. & STAIR, R. E. (1987). Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia. Journal of Cerebral Blood Flow and Metabolism 7, 679-686.
30. PRABHAKAR, N. R. (1994). Neurotransmitters in the carotid body. In Arterial Chemoreceptors: Cell to System, Advances in Experimental Medicine and Biology, ed. O'REGAN, R. G., NOLAN, P., MCQUEEN, D. S. & PATERSON, D. J., pp. 679-686. Plenum Press, New York.
31. 2-adenosine receptors in DDT1 MF-2 cells. Molecular Pharmacology 40, 639-647.
32. 2+ and PKC. Kidney International 51, 536-541.
33. RUNOLD, M., CHENIACK, N. S. & PRABHAKAR, N. R. (1990). Effect of adenosine on isolated and superfused cat carotid body activity. Neuroscience Letters 113, 111-114.
34. SALOMON, Y., LONDOS, C. & RODBELL, M. (1974). A highly sensitive adenylate cyclase assay. Analytical Biochemistry 58, 541-548.
35. 2 chemoreceptors by chronic hypoxia and cAMP in vitro. Journal of Neuroscience 15, 2192-2202.
36. WATT, A. H., REID, P. G., STEPHENS, M. R. & ROUTLEDGE, P. A. (1987). Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body? British Journal of Clinical Pharmacology 23, 486-490.
37. WEIL, J. V. (1986). Ventilatory control at high altitude. In Handbook of Physiology, section 3, The Respiratory System, vol. II, Control of Breathing, part 2, ed. CHERNIACK, N. S. & WIDDICOMBE, J. G., pp. 701-728. American Physiological Society, Bethesda, MD, USA.
38. WICKMAN, K. & CLAPMAN D. E. (1995). Ion channel regulation by G proteins. Physiological Reviews 75, 865-885.
39. WILLIAMS, M., ABREU, M., JARVIS, M. F. & NORONHA-BLOB, L. (1987). Characterization of adenosine receptors in the PC12 cell pheochromocytoma cell line using radioligand binding: evidence for A-2 selectivity. Journal of Neurochemistry 48, 498-502.
40. WINN, H. R., RUBIO, R. & BERNE, R. M. (1981). Brain adenosine concentration during hypoxia in rats. American Journal of Physiology 241, H235-242.
41. + currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction. Proceedings of the National Academy of Sciences of the USA 92, 295-299.
42. XIONG, Z., SPERELAKIS, N. & FENOGLO-PREISER, C. (1994). Regulation of L-type calcium channels by cyclic nucleotides and phosphorylation in smooth muscle cells from rabbit portal vein. Journal of Vascular Research 31, 271-279.
43. ZETTERSTROM, T., VERNET, L., UNGERSTEDT, U, TOSSMAN, U., JONZON, B. & FREDHOLM, B. B. (1982). Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neuroscience Letters 29, 111-115.
44. + current. American Journal of Physiology 271, C658-665.