메뉴 건너뛰기




Volumn 21, Issue 1, 2006, Pages 41-47

A comparison of folic acid deficiency-induced genomic instability in lymphocytes of breast cancer patients and normal non-cancer controls from a Chinese population in Yunnan

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; APOPTOSIS; ARTICLE; BREAST CANCER; CELL NUCLEUS; CHINESE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINESIS; CYTOTOXICITY; FEMALE; FOLIC ACID DEFICIENCY; GENE FREQUENCY; GENETIC DAMAGE; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE CULTURE; MICRONUCLEUS TEST; NECROSIS; PRIORITY JOURNAL;

EID: 33344465648     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/gei069     Document Type: Article
Times cited : (18)

References (35)
  • 1
    • 0035906343 scopus 로고    scopus 로고
    • DNA damage from micronutrient deficiencies is likely to be a major cause of cancer
    • Ames,B.N. (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat. Res., 475, 7-20.
    • (2001) Mutat. Res. , vol.475 , pp. 7-20
    • Ames, B.N.1
  • 2
    • 19844378446 scopus 로고    scopus 로고
    • Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, β-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability - Results from a dietary intake and micronucleus index survey in South Australia
    • Fenech,M., Baghurst,P., Luderer,W., Turner,J., Record,S., Ceppi,M. and Bonassi,S. (2005) Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, β-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability - results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis, 26, 991-999.
    • (2005) Carcinogenesis , vol.26 , pp. 991-999
    • Fenech, M.1    Baghurst, P.2    Luderer, W.3    Turner, J.4    Record, S.5    Ceppi, M.6    Bonassi, S.7
  • 3
    • 0037790638 scopus 로고    scopus 로고
    • Nutritional treatment of genome instability: A paradigm shift in disease prevention and in the setting of recommended dietary allowances
    • Fenech,M. (2003) Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutrition Res. Rev., 16, 109-122.
    • (2003) Nutrition Res. Rev. , vol.16 , pp. 109-122
    • Fenech, M.1
  • 4
    • 0022842769 scopus 로고
    • Role of vitamin B-12 and folate deficiencies in carcinogenesis
    • Poirier,L.A., Newberne,P.M. and Pariza,M.W.(eds), Plenum, NY
    • Eto,I. and Krumdieck,C.L. (1986) Role of vitamin B-12 and folate deficiencies in carcinogenesis. In Poirier,L.A., Newberne,P.M. and Pariza,M.W.(eds), Essential Nutrients in carcinogenesis, Plenum, NY, pp. 313-331.
    • (1986) Essential Nutrients in Carcinogenesis , pp. 313-331
    • Eto, I.1    Krumdieck, C.L.2
  • 5
    • 0035906327 scopus 로고    scopus 로고
    • The role of folic acid and vitamin B12 in genomic stability of human cells
    • Fenech,M. (2001) The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat. Res., 475, 56-67.
    • (2001) Mutat. Res. , vol.475 , pp. 56-67
    • Fenech, M.1
  • 6
    • 0032860818 scopus 로고    scopus 로고
    • Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells
    • Melnyk,S., Pogribna,M., Miller,B.J., Basnakian,A.G., Pogribny,I.P. and James,S.J. (1999) Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett., 146, 35-44.
    • (1999) Cancer Lett. , vol.146 , pp. 35-44
    • Melnyk, S.1    Pogribna, M.2    Miller, B.J.3    Basnakian, A.G.4    Pogribny, I.P.5    James, S.J.6
  • 9
    • 0034792891 scopus 로고    scopus 로고
    • The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro
    • Crott,J.W., Mashiyama,S.T., Ames,B.N. and Fenech,M. (2001a) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidem. Biomar., 10, 1089-1096.
    • (2001) Cancer Epidem. Biomar. , vol.10 , pp. 1089-1096
    • Crott, J.W.1    Mashiyama, S.T.2    Ames, B.N.3    Fenech, M.4
  • 10
    • 0036312756 scopus 로고    scopus 로고
    • The impact of chromatin in human cancer: Linking DNA methylation to gene silencing
    • Ballestar,E. and Esteller,M. (2002) The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis, 23, 1103-1109.
    • (2002) Carcinogenesis , vol.23 , pp. 1103-1109
    • Ballestar, E.1    Esteller, M.2
  • 11
    • 3042591660 scopus 로고    scopus 로고
    • Folate deficiency induces aneuploidy in human lymphocytes in vitro - Evidence using cytokinesis-blocked cells and probes specific for chromosome 17 and 21
    • Wang,X., Thomas,P., Xue,J.L. and Fenech,M. (2004) Folate deficiency induces aneuploidy in human lymphocytes in vitro - evidence using cytokinesis-blocked cells and probes specific for chromosome 17 and 21. Mutat. Res., 551, 167-180.
    • (2004) Mutat. Res. , vol.551 , pp. 167-180
    • Wang, X.1    Thomas, P.2    Xue, J.L.3    Fenech, M.4
  • 12
    • 9144231853 scopus 로고    scopus 로고
    • Centrosome amplification and the origin of chromosomal instability in breast cancer
    • Salisbury,J.L., D'Assoro,A.B. and Lingle,W.L. (2004) Centrosome amplification and the origin of chromosomal instability in breast cancer. J. Mammary Gland Biol. Neoplasia, 9, 275-283.
    • (2004) J. Mammary Gland Biol. Neoplasia , vol.9 , pp. 275-283
    • Salisbury, J.L.1    D'Assoro, A.B.2    Lingle, W.L.3
  • 13
    • 1842579223 scopus 로고    scopus 로고
    • Chromosomal instability and double minute chromosomes in a breast cancer patient
    • Lalic,H., Volavsek,C. and Radosevic-stasic,B. (2004) Chromosomal instability and double minute chromosomes in a breast cancer patient. Acta. Med. Okayama, 58, 51-58.
    • (2004) Acta. Med. Okayama , vol.58 , pp. 51-58
    • Lalic, H.1    Volavsek, C.2    Radosevic-stasic, B.3
  • 14
    • 0033007272 scopus 로고    scopus 로고
    • Folate and carcinogenesis: Evidence, mechanisms, and implications
    • Kim,Y.I. (1999) Folate and carcinogenesis: evidence, mechanisms, and implications. J. Nutr. Biochem., 10, 66-68.
    • (1999) J. Nutr. Biochem. , vol.10 , pp. 66-68
    • Kim, Y.I.1
  • 15
    • 0034046665 scopus 로고    scopus 로고
    • Folate and carcinogenesis: Developing a unifying hypothesis
    • Mason,J.B. and Choi,S.W. (2000) Folate and carcinogenesis: developing a unifying hypothesis. Adv. Enzyme Regul., 40, 127-141.
    • (2000) Adv. Enzyme Regul. , vol.40 , pp. 127-141
    • Mason, J.B.1    Choi, S.W.2
  • 17
    • 0037112246 scopus 로고    scopus 로고
    • Chromosomal biomarkers of genomic instability relevant to cancer
    • Fenech,M. (2002) Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today, 7, 1128-1137.
    • (2002) Drug Discov. Today , vol.7 , pp. 1128-1137
    • Fenech, M.1
  • 18
    • 0037173452 scopus 로고    scopus 로고
    • Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficiency human lymphocytes - Evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    • Fenech,M. and Crott,J.W. (2002) Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficiency human lymphocytes - evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat. Res., 504, 131-136.
    • (2002) Mutat. Res. , vol.504 , pp. 131-136
    • Fenech, M.1    Crott, J.W.2
  • 19
    • 0037238069 scopus 로고    scopus 로고
    • The comparison of folic acid and 5-methyl tetrahydrofolic acid deficiencies on chromosome damage in human lymphocytes in vitro
    • Wang,X. and Fenech,M. (2003) The comparison of folic acid and 5-methyl tetrahydrofolic acid deficiencies on chromosome damage in human lymphocytes in vitro. Mutagenesis, 18, 81-86.
    • (2003) Mutagenesis , vol.18 , pp. 81-86
    • Wang, X.1    Fenech, M.2
  • 20
    • 0034650339 scopus 로고    scopus 로고
    • Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families
    • Rothfuss,A., Schutz,P., Bochum,S., Volm,T., Eberhardt,E., Kreienberg,R., Vogel,W. and Speit,G. (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60, 390-394.
    • (2000) Cancer Res. , vol.60 , pp. 390-394
    • Rothfuss, A.1    Schutz, P.2    Bochum, S.3    Volm, T.4    Eberhardt, E.5    Kreienberg, R.6    Vogel, W.7    Speit, G.8
  • 21
    • 0037011657 scopus 로고    scopus 로고
    • Chromosomal radiasensitivity in breast cancer patients with a known or putative genetic predisposition
    • Baeyens,A., Thierens,H., Claes,K., Poppe B., Messiaen,L., Ridder,L.D. and Vral,A. (2002) Chromosomal radiasensitivity in breast cancer patients with a known or putative genetic predisposition. Br. J. Cancer, 87, 1379-1385.
    • (2002) Br. J. Cancer , vol.87 , pp. 1379-1385
    • Baeyens, A.1    Thierens, H.2    Claes, K.3    Poppe, B.4    Messiaen, L.5    Ridder, L.D.6    Vral, A.7
  • 23
    • 0037139239 scopus 로고    scopus 로고
    • Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation
    • Trenz,K., Rothfuss,A., Schutz,P. and Speit G. (2002) Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutat. Res., 500, 89-96.
    • (2002) Mutat. Res. , vol.500 , pp. 89-96
    • Trenz, K.1    Rothfuss, A.2    Schutz, P.3    Speit, G.4
  • 24
    • 0345254953 scopus 로고    scopus 로고
    • Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics
    • Trenz,K., Lugowski,S., Jahrsdorfer,U., Jainta,S., Vogel,W. and Speit,G. (2003) Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. Mutat. Res., 544, 279-288.
    • (2003) Mutat. Res. , vol.544 , pp. 279-288
    • Trenz, K.1    Lugowski, S.2    Jahrsdorfer, U.3    Jainta, S.4    Vogel, W.5    Speit, G.6
  • 25
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech,M. (2000) The in vitro micronucleus technique. Mutat. Res., 455, 81-95.
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 26
    • 0346726185 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymerphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes
    • Kimura,M., Umegaki,K., Higuchi,M., Thomas,P. and Fenech,M. (2004) Methylenetetrahydrofolate reductase C677T polymerphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J. Nutr., 134, 48-56.
    • (2004) J. Nutr. , vol.134 , pp. 48-56
    • Kimura, M.1    Umegaki, K.2    Higuchi, M.3    Thomas, P.4    Fenech, M.5
  • 27
    • 0034936018 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism dose not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro
    • Crott,J.W., Mashiyama,S.T., Ames,B.N. and Fenech,M. (2001) Methylenetetrahydrofolate reductase C677T polymorphism dose not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis, 22, 1019-1025.
    • (2001) Carcinogenesis , vol.22 , pp. 1019-1025
    • Crott, J.W.1    Mashiyama, S.T.2    Ames, B.N.3    Fenech, M.4
  • 28
    • 0035841813 scopus 로고    scopus 로고
    • Analysing controlled trials with baseline and follow up measurements
    • Andrew,J.V. and Douglas,G.A. (2001) Analysing controlled trials with baseline and follow up measurements. Brit. Med. J., 323, 1123-1124.
    • (2001) Brit. Med. J. , vol.323 , pp. 1123-1124
    • Andrew, J.V.1    Douglas, G.A.2
  • 29
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • Xu,X., Weaver,Z., Linke,S.P., Li,C., Gotay,J., Wang,X.W., Harris,C.C., Ried,T. and Deng,C.X. (1999) Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell, 3, 389-95.
    • (1999) Mol. Cell , vol.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.W.6    Harris, C.C.7    Ried, T.8    Deng, C.X.9
  • 30
    • 0034007114 scopus 로고    scopus 로고
    • Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay
    • Rajeswari,N., Ahuja,Y.R., Malini,U., Chandrashekar,S., Balakrishna,N., Rao,K.V. and Khar,A. (2000) Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay. Carcinogenesis, 21, 557-561.
    • (2000) Carcinogenesis , vol.21 , pp. 557-561
    • Rajeswari, N.1    Ahuja, Y.R.2    Malini, U.3    Chandrashekar, S.4    Balakrishna, N.5    Rao, K.V.6    Khar, A.7
  • 31
  • 32
    • 0033533731 scopus 로고    scopus 로고
    • Absence of BRCA2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
    • Tutt,A., Gabriel,A., Bertwistle,D., Connor,F., Paterson,H., Peacock,J., Ross,G. and Ashworth,A. (1999) Absence of BRCA2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr. Biol., 9, 1107-1110.
    • (1999) Curr. Biol. , vol.9 , pp. 1107-1110
    • Tutt, A.1    Gabriel, A.2    Bertwistle, D.3    Connor, F.4    Paterson, H.5    Peacock, J.6    Ross, G.7    Ashworth, A.8
  • 34
    • 7444222440 scopus 로고    scopus 로고
    • Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2
    • Daniels,M.J., Wang,Y., Lee,M. and Venkitaraman,A.R. (2004) Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science, 306, 876-879.
    • (2004) Science , vol.306 , pp. 876-879
    • Daniels, M.J.1    Wang, Y.2    Lee, M.3    Venkitaraman, A.R.4
  • 35
    • 33344462670 scopus 로고    scopus 로고
    • Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency
    • Sep 14; [Epub ahead of print]
    • Beetstra,S., Salisbury,C., Turner,J., Altree,M., McKinnon,R., Suthers,G. and Fenech,M. (2005) Lymphocytes of BRCA1 and BRCA2 germ-line mutation carriers, with or without breast cancer, are not abnormally sensitive to the chromosome damaging effect of moderate folate deficiency. Carcinogenesis, Sep 14; [Epub ahead of print].
    • (2005) Carcinogenesis
    • Beetstra, S.1    Salisbury, C.2    Turner, J.3    Altree, M.4    McKinnon, R.5    Suthers, G.6    Fenech, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.