Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro

Carcinogenesis

Volumn 22, Issue 7, 2001, Pages 1019-1025

  Crott, Jimmy W ^a,b   Mashiyama, Susan T ^c   Ames, Bruce N ^c   Fenech, Michael F ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DEOXYURIDINE PHOSPHATE; DNA; DOUBLE STRANDED DNA; FOLIC ACID; THYMIDINE; URACIL;

ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; AMINO ACID SYNTHESIS; ARTICLE; CANCER RISK; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION FUNCTION; CULTURE MEDIUM; DNA STRAND BREAKAGE; ENZYME POLYMORPHISM; FEMALE; FOLIC ACID DEFICIENCY; GAS CHROMATOGRAPHY; GENE ACTIVITY; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; LYMPHOCYTE CULTURE; MALE; MASS SPECTROMETRY; MICRONUCLEUS; PRIORITY JOURNAL; RISK FACTOR;

EID: 0034936018     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.7.1019     Document Type: Article

References (52)

1. Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification
2. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency
3. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene and description of five novel mutations in MTHFR
4. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase [letter]
5. Identification of four novel mutations in severe methylenetetrahydrofolate reductase deficiency
6. Worldwide distribution of a common methylenetetrahydrofolate reductase mutation
7. Plasma homocysteine levels related to interactions between folic acid status and methylenetetrahydrofolate reductase: A study in 52 healthy subjects
8. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
9. Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation
10. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility
11. Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease and its clinical implications
12. Polymorphisms in genes involved in folic acid metabolism as maternal risk factors for Down syndrome
13. Abnormal folic acid metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
14. The 'thermolabile' variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
15. Is the common 677C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis
16. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folic acid levels in red blood cells and risk of neural tube defects
17. Methylenetetrahydrofolate reductase, diet and risk of colon cancer
18. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
19. Methylenetetrahydrofolate reductase polymorphism, dietary interactions and risk of colorectal cancer
20. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk of colorectal adenoma
21. Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas
22. Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction?
23. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
24. Folic acid deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
25. DNA instability (strand breakage, uracil misincorporation and defective repair) is increased by folic acid depletion in human lymphocytes in vitro
26. Uracil misincorporation, DNA strand breaks and gene amplication are associated with tumorigenic cell transformation in folic acid deficient/repleted Chinese hamster ovary cells
27. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation
28. Quality control by DNA repair
29. Chromosomal aberrations in lymphocytes predict human cancer: A report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH)
30. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens
31. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
32. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folic acid/cobalamin disorders
33. Culture Media for Human Cells-RPMI 1603, RPMI 1634, RPMI 1640 and GEM 1717
34. The in vitro micronucleus technique
35. Analysis of uracil in DNA by gas chromatography-mass spectrometry
36. 12, homocysteine status and DNA damage in young Australian adults
37. Moderate folic acid depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
38. 12 on plasma homocysteine concentrations in healthy, young women
39. 12 and folic acid
40. A comparison of lymphocyte micronuclei and plasma micronutrients in vegetarians and non-vegetarians
41. Apoptosis of late-stage erythroblasts in megaloblastic anemia: Association with DNA damage and macrocyte production
42. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
43. DNA methylation and cancer
44. DNA methylation as an intermediate biomarker in colorectal cancer: Modulation by folic acid supplementation
45. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
46. DNA methylation: Past, present and future directions
47. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
48. Polygenic influence on plasma homocysteine: Association of two prevalent mutations, the 844ins68 of cystathionine β-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels
49. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folic acid ameliorates human hyperhomocysteinemia
50. Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
51. 6 status on homocysteine metabolism
52. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties and inhibition by S-adenosylmethionine