Clinical implications of T cell receptor repertoire analysis after allogeneic stem cell transplantation

Hematology

Volumn 9, Issue 3, 2004, Pages 189-198

  O'Keefe, Christine L ^a   Risitano, Antonio M ^b   Maciejewski, Jaroslaw P ^a,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

CDR3 sequencing; Graft versus host; Graft versus leukemia; Stem cell transplantation; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELLULAR IMMUNODEFICIENCY; CLONAL VARIATION; CYTOMEGALOVIRUS INFECTION; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; INFECTION SENSITIVITY; LYMPHOCYTE FUNCTION; MOLECULAR GENETICS; PHENOTYPE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; T LYMPHOCYTE SUBPOPULATION;

EID: 3242876509     PISSN: 10245332     EISSN: None     Source Type: Journal    
DOI: 10.1080/10245330410001701530     Document Type: Article

References (108)

1. Teshima, T. and Ferrara, J.L. (2002) "Understanding the alloresponse: new approaches to graft-versus-host disease prevention", Semin. Hematol. 39, 15-22.
2. Ratanatharathorn, V., Ayash, L., Lazarus, H.M., Fu, J. and Uberti, J.P. (2001) "Chronic graft-versus-host disease: clinical manifestation and therapy", Bone Marrow Transplant. 28, 121-129.
3. Goker, H., Haznedaroglu, I.C. and Chao, N.J. (2001) "Acute graft-vs-host disease: pathobiology and management", Exp. Hematol. 29, 259-277.
4. Ferrara, J.L., Cooke, K.R., Pan, L. and Krenger, W. (1996) "The immunopathophysiology of acute graft-versus-host-disease" , Stem Cells 14, 473-489.
5. Godthelp, B.C., van Tol, M.J., Vossen, J.M. and van den Elsen, P.J. (1999) "T-Cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell-depleted or unmanipulated grafts: evaluation of overall and antigen-specific T-cell repertoires", Blood 94, 4358-4369.
6. Hirokawa, M., Horiuchi, T., Kitabayashi, A., Kawabata, Y., Matsutani, T., Suzuki, R., Chihara, J. and Miura, A.B. (2000) " Delayed recovery of CDR3 complexity of the T-cell receptor-beta chain in recipients of allogeneic bone marrow transplants who had virus-associated interstitial pneumonia: monitor of T-cell function by CDR3 spectratyping", J. Allergy Clin. Immunol. 106, S32-S39.
7. Wu, C.J., Chillemi, A., Alyea, E.P., Orsini, E., Neuberg, D., Soiffer, R.J. and Ritz, J. (2000) "Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism", Blood 95, 352-359.
8. Chan, A. and Mak, T.W. (1989) "Genomic organization of the T cell receptor", Cancer Detect. Prev. 14, 261-267.
9. Moss, P.A., Rosenberg, W.M. and Bell, J.I. (1992) "The human T cell receptor in health and disease", Annu. Rev. Immunol. 10, 71-96.
10. Garcia, K.C., Teyton, L. and Wilson, I.A. (1999) "Structural basis of T cell recognition", Annu. Rev. Immunol. 17, 369-397.
11. Arstila, T.P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J. and Kourilsky, P. (2000) "Diversity of human alpha beta T cell receptors", Science 288, 1135.
12. Champlin, R.E., Passweg, J.R., Zhang, M.J., Rowlings, P.A., Pelz, C.J., Atkinson, K.A., Barrett, A.J., Cahn, J.Y., Drobyski, W.R., Gale, R.P., Goldman, J.M., Gratwohl, A., Gordon-Smith, E.C., Henslee-Downey, P.J., Herzig, R.H., Klein, J.P., Marmont, A.M., O'Reilly, R.J., Ringden, O., Slavin, S., Sobocinski, K.A., Speck, B., Weiner, R.S. and Horowitz, M.M. (2000) "T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities", Blood 95, 3996-4003.
13. Gorski, J., Yassai, M., Zhu, X., Kissela, B., Kissella, B., Keever, C. and Flomenberg, N. (1994) "Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status", J. Immunol. 152, 5109-5119.
14. Breit, T.M., Verschuren, M.C., Wolvers-Tettero, I.L., Gastel-Mol, E.J., Hahlen, K. and van Dongen, J.J. (1997) "Human T cell leukemias with continuous V(D)J recombinase activity for TCR-delta gene deletion", J. Immunol. 159, 4341-4349.
15. Verschuren, M.C., Wolvers-Tettero, I.L., Breit, T.M., Noordzij, J., van Wering, E.R. and van Dongen, J.J. (1997) " Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells", J. Immunol. 158, 1208-1216.
16. Livak, F. and Schatz, D.G. (1996) "T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells", Mol. Cell. Biol. 16, 609-618.
17. Takeshita, S., Toda, M. and Yamagishi, H. (1989) "Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus", EMBO J. 8, 3261-3270.
18. Kong, F.K., Chen, C.L., Six, A., Hockett, R.D. and Cooper, M.D. (1999) "T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool", Proc. Natl Acad. Sci. USA 96, 1536-1540.
19. Douek, D.C., McFarland, R.D., Keiser, P.H., Gage, E.A., Massey, J.M., Haynes, B.F., Polis, M.A., Haase, A.T., Feinberg, M.B., Sullivan, J.L., Jamieson, B.D., Zack, J.A., Picker, L.J. and Koup, R.A. (1998) "Changes in thymic function with age and during the treatment of HIV infection", Nature 396, 690-695.
20. Talvensaari, K., Clave, E., Douay, C., Rabian, C., Garderet, L., Busson, M., Garnier, F., Douek, D., Gluckman, E., Charron, D. and Toubert, A. (2002) "A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation", Blood 99, 1458-1464.
21. Altman, J.D., Moss, P.A., Goulder, P.J., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J. and Davis, M.M. (1996) "Phenotypic analysis of antigen-specific T lymphocytes" , Science 274, 94-96.
22. Mutis, T., Gillespie, G., Schrama, E., Falkenburg, J.H., Moss, P. and Goulmy, E. (1999) "Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease", Nat. Med. 5, 839-842.
23. Romero, P., Dunbar, P.R., Valmori, D., Pittet, M., Ogg, G.S., Rimoldi, D., Chen, J.L., Lienard, D., Cerottini, J.C. and Cerundolo, V. (1998) "Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes", J. Exp. Med. 188, 1641-1650.
24. Hutchings, P.R., Cambridge, G., Tite, J.P., Meager, T. and Cooke, A. (1989) "The detection and enumeration of cytokine-secreting cells in mice and man and the clinical application of these assays", J. Immunol. Methods 120, 1-8.
25. Suni, M.A., Picker, L.J. and Maino, V.C. (1998) "Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry", J. Immunol. Methods 212, 89-98.
26. Nomura, L.E., Walker, J.M. and Maecker, H.T. (2000) "Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells", Cytometry 40, 60-68.
27. Wang, W., Meadows, L.R., den Haan, J.M., Sherman, N.E., Chen, Y., Blokland, E., Shabanowitz, J., Agulnik, A.I., Hendrickson, R.C. and Bishop, C.E. (1995) "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein", Science 269, 1588-1590.
28. Maecker, H.T., Maino, V.C. and Picker, L.J. (2000) "Immunofluorescence analysis of T-cell responses in health and disease", J. Clin. Immunol. 20, 391-399.
29. Dickinson, A.M., Wang, X.N., Sviland, L., Vyth-Dreese, F.A., Jackson, G.H., Schumacher, T.N., Haanen, J.B., Mutis, T. and Goulmy, E. (2002) "In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens", Nat. Med. 8, 410-414.
30. van den Beemd, R., Boor, P.P., van Lochem, E.G., Hop, W.C., Langerak, A.W., Wolvers-Tettero, I.L., Hooijkaas, H. and van Dongen, J.J. (2000) "Flow cytometric analysis of the Vbeta repertoire in healthy controls", Cytometry 40, 336-345.
31. Plasilova, M., Risitano, A. and Maciejewski, J.P. (2003) "Application of the molecular analysis of the T cell receptor repertoire in the study of immune-mediated hematologic disease", Hematol. J. 8, 173-181.
32. Risitano, A.M., Kock, H., Zeng, W., Chen, G., Young, N.S. and Maciejewski, J.P. (2002) "Significance of oligoclonal and polyclonal expansion within CD8 and CD4 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by VB CDR3 spectratyping and flow ctyometry", Blood, 178-183.
33. Zaia, J.A., Sissons, J.G., Riddell, S., Diamond, D.J., Wills, M.R., Carmichael, A.J., Weekes, M.P., Gandhi, M., Rosa, C.L., Villacres, M., Lacey, S., Markel, S. and Sun, J. (2000) "Status of Cytomegalovirus Prevention and Treatment in 2000", Hematology (Am. Soc. Hematol. Edu. Program), 339-355.
34. Kuzushima, K., Hoshino, Y., Fujii, K., Yokoyama, N., Fujita, M., Kiyono, T., Kimura, H., Morishima, T., Morishima, Y. and Tsurumi, T. (1999) "Rapid determination of Epstein-Barr virus-specific CD8(+) T-cell frequencies by flow cytometry", Blood 94, 3094-3100.
35. Gillespie, G.M., Wills, M.R., Appay, V., O'Callaghan, C., Murphy, M., Smith, N., Sissons, P., Rowland-Jones, S., Bell, J.I. and Moss, P.A. (2000) "Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors", J. Virol. 74, 8140-8150.
36. Weekes, M.P., Carmichael, A.J., Wills, M.R., Mynard, K. and Sissons, J.G. (1999) "Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones", J. Immunol. 162, 7569-7577.
37. Singhal, S., Shaw, J.C., Ainsworth, J., Hathaway, M., Gillespie, G.M., Paris, H., Ward, K., Pillay, D., Moss, P.A. and Mutimer, D.J. (2000) "Direct visualization and quantitation of cytomegalovirus-specific CD8+ cytotoxic T-lymphocytes in liver transplant patients", Transplantation 69, 2251-2259.
38. Hong, J., Zang, Y.C., Tejada-Simon, M.V., Kozovska, M., Li, S., Singh, R.A., Yang, D., Rivera, V.M., Killian, J.K. and Zhang, J.Z. (1999) "Acommon TCR V-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis", J. Immunol. 163, 3530-3538.
39. Luppi, P., Zanone, M.M., Hyoty, H., Rudert, W.A., Haluszczak, C., Alexander, A.M., Bertera, S., Becker, D. and Trucco, M. (2000) "Restricted TCR V beta gene expression and enterovirus infection in type I diabetes: a pilot study", Diabetologia 43, 1484-1497.
40. Zoumbos, N.C., Ferris, W.O., Hsu, S.M., Goodman, S., Griffith, P., Sharrow, S.O., Humphries, R.K., Nienhuis, A.W. and Young, N. (1984) "Analysis of lymphocyte subsets in patients with aplastic anaemia", Br. J. Haematol. 58, 95-105.
41. Bour, H., Puisieux, I., Even, J., Kourilsky, P., Favrot, M., Musette, P. and Nicolas, J.F. (1999) "T-cell repertoire analysis in chronic plaque psoriasis suggests an antigen-specific immune response", Hum. Immunol. 60, 665-676.
42. Manz, C.Y., Dietrich, P.Y., Schnuriger, V., Nissen, C. and Wodnar-Filipowicz, A. (1997) "T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia", Blood Cells Mol. Dis. 23, 110-122.
43. Zeng, W., Nakao, S., Takamatsu, H., Yachie, A., Takami, A., Kondo, Y., Sugimori, N., Yamazaki, H., Miura, Y., Shiobara, S. and Matsuda, T. (1999) "Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia", Blood 93, 3008-3016.
44. Epperson, D.E., Nakamura, R., Saunthararajah, Y., Melenhorst, J. and Barrett, A.J. (2001) "Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process", Leuk. Res. 25, 1075-1083.
45. Storek, J., Joseph, A., Dawson, M.A., Douek, D.C., Storer, B. and Maloney, D.G. (2002) "Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation", Transplantation 73, 1154-1158.
46. Storek, J., Joseph, A., Espino, G., Dawson, M.A., Douek, D.C., Sullivan, K.M., Flowers, M.E., Martin, P., Mathioudakis, G., Nash, R.A., Storb, R., Appelbaum, F.R. and Maloney, D.G. (2001) "Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation", Blood 98, 3505-3512.
47. Haynes, B.F., Markert, M.L., Sempowski, G.D., Patel, D.D. and Hale, L.P. (2000) "The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection", Annu. Rev. Immunol. 18, 529-560.
48. Dumont-Girard, F., Roux, E., van Lier, R.A., Hale, G., Helg, C., Chapuis, B., Starobinski, M. and Roosnek, E. (1998) " Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants" , Blood 92, 4464-4471.
49. Roux, E., Dumont-Girard, F., Starobinski, M., Siegrist, C.A., Helg, C., Chapuis, B. and Roosnek, E. (2000) "Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity", Blood 96, 2299-2303.
50. Eyrich, M., Croner, T., Leiler, C., Lang, P., Bader, P., Klingebiel, T., Niethammer, D. and Schlegel, P.G. (2002) "Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors", Blood 100, 1915-1918.
51. Hochberg, E.P., Chillemi, A.C., Wu, C.J., Neuberg, D., Canning, C., Hartman, K., Alyea, E.P., Soiffer, R.J., Kalams, S.A. and Ritz, J. (2001) "Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults", Blood 98, 1116-1121.
52. Weinberg, K., Blazar, B.R., Wagner, J.E., Agora, E., Hill, B.J., Smogorzewska, M., Koup, R.A., Betts, M.R., Collins, R.H. and Douek, D.C. (2001) "Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation", Blood 97, 1458-1466.
53. Verfuerth, S., Peggs, K., Vyas, P., Barnett, L., O'Reilly, R.J. and Mackinnon, S. (2000) "Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire", Blood 95, 3990-3995.
54. Matsutani, T., Yoshioka, T., Tsuruta, Y., Iwagami, S., Toyosaki-Maeda, T., Horiuchi, T., Miura, A.B., Watanabe, A., Takada, G., Suzuki, R. and Hirokawa, M. (2000) "Restricted usage of T-cell receptor alpha-chain variable region (TCRAV) and T-cell receptor beta-chain variable region (TCRBV) repertoires after human allogeneic haematopoietic transplantation", Br. J. Haematol. 109, 759-769.
55. Bellucci, R., Alyea, E.P., Weller, E., Chillemi, A., Hochberg, E., Wu, C.J., Canning, C., Schlossman, R., Soiffer, R.J., Anderson, K.C. and Ritz, J. (2002) "Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma", Blood 99, 4610-4617.
56. Dietrich, P.Y., Caignard, A., Lim, A., Chung, V., Pico, J.L., Pannetier, C., Kourilsky, P., Hercend, T., Even, J. and Triebel, F. (1994) "In vivo T-cell clonal amplification at time of acute graft-versus-host disease", Blood 84, 2815-2820.
57. Gaschet, J., Gallot, G., Ibisch, C., Lim, A., Even, J., Vivien, R., Hallet, M.M., Milpied, N. and Vie, H. (1998) "Acute graft-versus-host disease after bone marrow transplantation with a single HLA-DPB1*1001 mismatch: involvement of different TCRBV subsets", Bone Marrow Transplant. 22, 385-392.
58. Gaschet, J., Lim, A., Liem, L., Vivien, R., Hallet, M.M., Harousseau, J.L., Even, J., Goulmy, E., Bonneville, M., Milpied, N. and Vie, H. (1996) "Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPB1*0501 mismatch", J. Clin. Investig. 98, 100-107.
59. Jiang, Y.Z., Mavroudis, D.A., Dermime, S., Molldrem, J., Hensel, N.F. and Barrett, A.J. (1997) "Preferential usage of T cell receptor (TCR) V beta by allogeneic T cells recognizing myeloid leukemia cells: implications for separating graft-versus-leukemia effect from graft-versus-host disease", Bone Marrow Transplant. 19, 899-903.
60. Mavroudis, D.A., Dermine, S., Molldrem, J., Jiang, Y.Z., Raptis, A., van Rhee, F., Hensel, N., Fellowes, V., Eliopoulos, G. and Barrett, A.J. (1998) "Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions", Br. J. Haematol. 101, 565-570.
61. Epperson, D.E., Margolis, D.A., McOlash, L., Janczak, T. and Barrett, A.J. (2001) "In vitro T-cell receptor V beta repertoire analysis may identify which T-cell V beta families mediate graft-versus-leukaemia and graft-versus-host responses after human leucocyte antigen-matched sibling stem cell transplantation", Br. J. Haematol. 114, 57-62.
62. Gaschet, J., Milpied, N., Denis, C., Hallet, M.M., Davodeau, F., Bonneville, M. and Vie, H. (1995) "Oligoclonal T-cell repertoire and graft-versus-host disease after allogeneic bone marrow transplantation", Ann. N. Y. Acad. Sci. 756, 435-437.
63. Gaschet, J., Gallot, G., Ibisch, C., Lim, A., Even, J., Vivien, R., Hallet, M.M., Milpied, N. and Vie, H. (1998) "Acute graft-versus-host disease after bone marrow transplantation with a single HLA-DPB1*1001 mismatch: involvement of different TCRBV subsets", Bone Marrow Transplant. 22, 385-392.
64. Hirokawa, M., Matsutani, T., Saitoh, H., Ichikawa, Y., Kawabata, Y., Horiuchi, T., Kitabayashi, A., Yoshioka, T., Tsuruta, Y., Suzuki, R., Miura, A.B. and Sawada, K. (2002) "Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplantation", Bone Marrow Transplant. 30, 915-923.
65. Douek, D.C., Vescio, R.A., Betts, M.R., Brenchley, J.M., Hill, B.J., Zhang, L., Berenson, J.R., Collins, R.H. and Koup, R.A. (2000) "Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution", Lancet 355, 1875-1881.
66. Roncarolo, M.G., Bacchetta, R., Bordignon, C., Narula, S. and Levings, M.K. (2001) "Type 1 T regulatory cells", Immunol. Rev. 182, 68-79.
67. Horowitz, M.M., Gale, R.P., Sondel, P.M., Goldman, J.M., Kersey, J., Kolb, H.J., Rimm, A.A., Ringden, O., Rozman, C. and Speck, B. (1990) "Graft-versus-leukemia reactions after bone marrow transplantation", Blood 75, 555-562.
68. Weiden, P.L., Sullivan, K.M., Flournoy, N., Storb, R. and Thomas, E.D. (1981) "Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation", N. Engl. J. Med. 304, 1529-1533.
69. Fefer, A., Sullivan, K.M., Weiden, P., Buckner, C.D., Schoch, G., Storb, R. and Thomas, E.D. (1987) "Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation", Prog. Clin. Biol. Res. 244, 401-408.
70. Kolb, H.J. (1998) "Donor leukocyte transfusions for treatment of leukemic relapse after bone marrow transplantation. EBMT Immunology and Chronic Leukemia Working Parties", Vox Sang 74(Suppl. 2), 321-329.
71. Collins, R.H., Jr, Goldstein, S., Giralt, S., Levine, J., Porter, D., Drobyski, W., Barrett, J., Johnson, M., Kirk, A., Horowitz, M. and Parker, P. (2000) "Donor leukocyte infusions in acute lymphocytic leukemia", Bone Marrow Transplant. 26, 511-516.
72. Kolb, H.J., Schattenberg, A., Goldman, J.M., Hertenstein, B., Jacobsen, N., Arcese, W., Ljungman, P., Ferrant, A., Verdonck, L. and Niederwieser, D. (1995) "Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia", Blood 86, 2041-2050.
73. Collins, R.H., Jr, Shpilberg, O., Drobyski, W.R., Porter, D.L., Giralt, S., Champlin, R., Goodman, S.A., Wolff, S.N., Hu, W., Verfaillie, C., List, A., Dalton, W., Ognoskie, N., Chetrit, A., Antin, J.H. and Nemunaitis, J. (1997) "Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation", J. Clin. Oncol. 15, 433-444.
74. Fassas, A.B., Morris, C., Badros, A., van Rhee, F. and Tricot, G. (2002) "Separating graft-versus-tumor from graft-versus-host reactions", Leuk. Lymphoma 43, 725-733.
75. Patterson, A.E. and Korngold, R. (2001) "Infusion of select leukemia-reactive TCR Vbeta + T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation", Biol. Blood Marrow Transplant. 7, 187-196.
76. Kondo, Y., Shiobara, S. and Nakao, S. (2001) "Identification of T-cell clones showing expansion associated with graft-vs-leukemia effect on chronic myelogenous leukemia in vivo and in vitro", Exp. Hematol. 29, 471-476.
77. Claret, E.J., Alyea, E.P., Orsini, E., Pickett, C.C., Collins, H., Wang, Y., Neuberg, D., Soiffer, R.J. and Ritz, J. (1997) "Characterization of T cell repertoire in patients with graft-versus-leukemia after donor lymphocyte infusion", J. Clin. Investig. 100, 855-866.
78. Michalek, J., Collins, R.H., Durrani, H.P., Vaclavkova, P., Ruff, L.E., Douek, D.C. and Vitetta, E.S. (2003) "Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4+ T cells by virtue of their receptor beta loci sequences", Proc. Natl Acad. Sci. USA 100, 1180-1184.
79. Morgan, R.A., Dudley, M.E., Yu, Y.Y., Zheng, Z., Robbins, P.F., Theoret, M.R., Wunderlich, J.R., Hughes, M.S., Restifo, N.P. and Rosenberg, S.A. (2003) "High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens", J. Immunol. 171, 3287-3295.
80. Nakao, S. (2002) "Identification of novel minor histocompatibility antigens responsible for graft-versus-leukemia (GVL) effect on chronic myeloid leukemia: usefulness of determining the clonotype of T cells associated with GVL effect after donor leukocyte infusion", Int. J. Hematol. 76(Suppl. 1), 274-276.
81. Mutis, T. and Goulmy, E. (2002) "Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies", Semin. Hematol. 39, 23-31.
82. den Haan, J.M., Sherman, N.E., Blokland, E., Huczko, E., Koning, F., Drijfhout, J.W., Skipper, J., Shabanowitz, J., Hunt, D.F. and Engelhard, V.H. (1995) "Identification of a graft versus host disease-associated human minor histocompatibility antigen", Science 268, 1476-1480.
83. Goulmy, E., Schipper, R., Pool, J., Blokland, E., Falkenburg, J.H., Vossen, J., Grathwohl, A., Vogelsang, G.B., van Houwelingen, H.C. and van Rood, J.J. (1996) "Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation", N. Engl. J. Med. 334, 281-285.
84. Bocchia, M., Korontsvit, T., Xu, Q., Mackinnon, S., Yang, S.Y., Sette, A. and Scheinberg, D.A. (1996) "Specific human cellular immunity to bcr-abl oncogene-derived peptides", Blood 87, 3587-3592.
85. Yang, X.F., Wu, C.J., Chen, L., Alyea, E.P., Canning, C., Kantoff, P., Soiffer, R.J., Dranoff, G. and Ritz, J. (2002) "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells", Cancer Res. 62, 5517-5522.
86. Molldrem, J.J., Kant, S., Jiang, W. and Lu, S. (2002) "The basis of T-cell-mediated immunity to chronic myelogenous leukemia", Oncogene 21, 8668-8673.
87. Molldrem, J.J., Clave, E., Jiang, Y.Z., Mavroudis, D., Raptis, A., Hensel, N., Agarwala, V. and Barrett, A.J. (1997) " Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units", Blood 90, 2529-2534.
88. Molldrem, J.J., Lee, P.P., Wang, C., Felio, K., Kantalian, H.M., Champlin, R.E. and Davis, M.M. (2000) "Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia", Nat. Med. 6, 1018-1023.
89. Clark, R.E., Dodi, I.A., Hill, S.C., Lill, J.R., Aubert, G., Macintyre, A.R., Rojas, J., Bourdon, A., Bonner, P.L., Wang, L., Christmas, S.E., Travers, P.J., Creaser, C.S., Rees, R.C. and Madrigal, J.A. (2001) "Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein", Blood 98, 2887-2893.
90. Yotnda, P., Firat, H., Garcia-Pons, F., Garcia, Z., Gourru, G., Vernant, J.P., Lemonnier, F.A., Leblond, V. and Langlade-Demoyen, P. (1998) "Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia", J. Clin. Investig. 101, 2290-2296.
91. Moildrem, J.J., Kant, S., Lu, S., Rios, R., Streicher, H., Wang, C., Giralt, S., O'Brien, S., Cortes, J., Champlin, R., Martin, T. and Wieder, E. (2002) "Peptide Vaccination with PR1 Elicits Active T Cell Immunity That Induces Cytogenetic Remission in Acute Myelogenous Leukemia", Blood 100, 6a.
92. Solache, A., Morgan, C.L., Dodi, A.I., Morte, C., Scott, I., Baboonian, C., Zal, B., Goldman, J., Grundy, J.E. and Madrigal, JA. (1999) "Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus", J. Immunol. 163, 5512-5518.
93. Chen, F.E., Aubert, G., Travers, P., Dodi, I.A. and Madrigal, J.A. (2002) "HLA tetramers and anti-CMV immune responses: from epitope to immunotherapy", Cytotherapy 4, 41-48.
94. Cwynarski, K., Ainsworth, J., Cobbold, M., Wagner, S., Mahendra, P., Apperley, J., Goldman, J., Craddock, C. and Moss, P.A. (2001) "Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation", Blood 97, 1232-1240.
95. Hebart, H., Daginik, S., Stevanovic, S., Grigoleit, U., Dobler, A., Baur, M., Rauser, G., Sinzger, C., Jahn, G., Loeffler, J., Kanz, L., Rammensee, H.G. and Einsele, H. (2002) "Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation", Blood 99, 3830-3837.
96. Gratama, J.W., van Esser, J.W., Lamers, C.H., Tournay, C., Lowenberg, B., Bolhuis, R.L. and Cornelissen, J.J. (2001) "Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection", Blood 98, 1358-1364.
97. Li, C.R., Greenberg, P.D., Gilbert, M.J., Goodrich, J.M. and Riddell, S.R. (1994) "Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis", Blood 83, 1971-1979.
98. Khanna, R., Bell, S., Sherritt, M., Galbraith, A., Burrows, S.R., Rafter, L., Clarke, B., Slaughter, R., Falk, M.C., Douglass, J., Williams, T., Elliott, S.L. and Moss, D.J. (1999) "Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease", Proc. Natl Acad. Sci. USA 96, 10391-10396.
99. Savoldo, B., Huls, M.H., Liu, Z., Okamura, T., Volk, H.D., Reinke, P., Sabat, R., Babel, N., Jones, J.F., Webster-Cyriaque, J., Gee, A.P., Brenner, M.K., Heslop, H.E. and Rooney, C.M. (2002) " Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection", Blood 100, 4059-4066.
100. Comoli, P., Labirio, M., Basso, S., Baldanti, F., Grossi, P., Furione, M., Vigano, M., Fiocchi, R., Rossi, G., Ginevri, F., Gridelli, B., Moretta, A., Montagna, D., Locatelli, F., Gerna, G. and Maccario, R. (2002) "Infusion of autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication", Blood 99, 2592-2598.
101. Cohen, G.B., Islam, S.A., Noble, M.S., Lau, C., Brander, C., Altfeld, M.A., Rosenberg, E.S., Schmitz, J.E., Cameron, T.O. and Kalams, S.A. (2002) "Clonotype tracking of TCR repertoires during chronic virus infections", Virology 304, 474-484.
102. van Rhee, F. and Barrett, J. (2002) "Adoptive transfer of Ag-specific T cells to prevent CMV disease after allogeneic stem-cell transplantation", Cytotherapy 4, 3-10.
103. Peggs, K.S. and Mackinnon, S. (2002) "Clinical trials with CMV-specific T cells", Cytotherapy 4, 21-28.
104. Einsele, H., Rauser, G., Grigoleit, U., Hebart, H., Sinzger, C., Riegler, S. and Jahn, G. (2002) "Induction of CMV-specific T-cell lines using Ag-presenting cells pulsed with CMV protein or peptide", Cytotherapy 4, 49-54.
105. Einsele, H. (2003) "Antigen-specific T cells for the treatment of infections after transplantation", Hematol. J. 4, 10-17.
106. Solomon, S.R., Tran, T., Carter, C.S., Donnelly, S., Hensel, N., Schindler, J., Bahceci, E., Ghetie, V., Michalek, J., Mavroudis, D., Read, E.J., Vitetta, E.S. and Barrett, A.J. (2002) "Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation", Cytotherapy 4, 395-406.
107. Mackay, I. and Rosen, F.S. (2000) "The HLA system - first of two parts", NEJM 343, 702-709.
108. Davis, M.M. and Bjorkman, P.A. (1988) "T-cell antigen receptor gene and T-cell recognition", Nature 334, 395-402.