Human CD28-CD8+ T cells contain greatly expanded functional virus- specific memory CTL clones

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7569-7577

  Weekes, Michael P ^a   Carmichael, Andrew J ^a   Wills, Mark R ^a   Mynard, Kim ^a   Sissons, J G Patrick ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN;

ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CYTOLYSIS; DISULFIDE BOND; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; MEMORY CELL; MOLECULAR CLONING; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY; VIRUS CARRIER;

AMINO ACID SEQUENCE; ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; CYTOMEGALOVIRUS; EPITOPES, T-LYMPHOCYTE; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; HIV; HLA ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; PEPTIDES; STEM CELLS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033564321     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
2. - T lymphocytes: antigenic and functional properties. J. Immunol. 150:1147.
3. Borthwick, N. J., M. Bofill, W. M. Gombert, A. N. Akbar, E. Medina, K. Sagawa, M. C. Lipman, M. A. Johnson, and G. Janossy. 1994. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28-T cells. AIDS 8:431.
4. Brinchmann, J. E., J. H. Dobloug, B. H. Heger, L. L. Haaheim, M. Sannes, and T. Egeland. 1994. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J. Infect. Dis. 169:730.
5. + T cells from HIV-infected persons. J. Immunol. 153:412.
6. + T cells from HIV-infected subjects. Clin. Exp. Immunol. 100:425.
7. + counterparts. J. Immunol. 156:3587.
8. - T cell subsets in HIV type 1-infected individuals. Eur. J. Immunol. 28:1738.
9. Quinnan, G. V., Jr., W. H. Burns, N. Kirmani, A. H. Rook, J. Manischewitz, L. Jackson, G. W. Santos, and R. Saral. 1984. HLA-restricted cytotoxic T lymphocytes are an early immune response and important defence mechanism in cytomegalovirus infections. Rev. Infect. Dis. 6:156.
10. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
11. Borysiewicz, L. K., S. Graham, J. K. Hickling, P. D. Mason, and J. G. Sissons. 1988. Human cytomegalovirus-specific cytotoxic T cells: their precursor frequency and stage specificity. Eur. J. Immunol. 18:269.
12. Peters, B. S., E. J. Beck, S. Anderson, D. Coleman, R. Coker, J. Main, C. Migdal, J. R. Harris, and A. J. Pinching. 1991. Cytomegalovirus infection in AIDS: patterns of disease, response to therapy and trends in survival. J. Infect. 23:129.
13. Wills, M. R., A. J. Carmichael, K. Mynard, X. Jin, M. P. Weekes, B. Plachter, and J. G. Sissons. 1996. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70:7569.
14. Weekes, M. P., M. R. Wills, K. Mynard, A. J. Carmichael, and J. G. P. Sissons. 1999. The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J. Virol. 73:2099.
15. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650.
16. Borrow, P., H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer, H. Meyers, J. H. Nelson, J. E. Gairin, B. H. Hahn, M. B. A. Oldstone, et al. 1997. Antiviral pressure exerted by HIV-1 specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3:205.
17. Ogg, G., X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, et al. 1998. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279:2103.
18. Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
19. L genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J. Immunol. 147:1709.
20. + T cells comprise both naive and memory cells. J. Immunol. 162, In press.
21. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, Chapt. 9. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
22. Jin, X., M. Wills, J. G. P. Sissons, and A. Carmichael. 1998. Progressive loss of IL-2-expandable HIV-1-specific cytotoxic T lymphocytes during asymptomatic HIV infection. Eur. J. Immunol. 28:3564.
23. + T cells in chronic HIV infection are antigen specific. J. Exp. Med. 188:785.
24. Kalams, S. A., R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
25. Argaet, V. P., C. W. Schmidt, S. R. Burrows, S. L. Silins, M. G. Kurilla, D. L. Doolan, A. Suhrbier, D. J. Moss, E. Kieff, T. B. Sculley, et al. 1994. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 180:2335.
26. + cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J. Virol. 70:843.
27. Silins, S. L., S. M. Cross, S. L. Elliott, S. J. Pye, S. R. Burrows, J. M. Burrows, D. J. Moss, V. P. Argaet, and I. S. Misko. 1996. Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis. J. Exp. Med. 184:1815.
28. + T cells in health and disease: ageing, infection, or immune regulation? Hum. Immunol. 48:68.
29. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J. Immunol. 154:3538.
30. + subset in normal human subjects. J. Immunol. 151:5762.
31. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J. L. Casanova, and P. R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
32. + T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases. Mol. Med. 1:614.
33. + subset. J. Immunol. 154:6182.
34. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy" [published erratum appears in J Exp Med 1994 Mar 1; 179(3): 1077]. J. Exp. Med. 179:609.
35. + T cell clones in elderly humans. J. Immunol. 158:4493.
36. + T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J. Immunol. 155:5046.
37. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177.
38. Gomez, A., I. Bourgault, E. Gomard, F. Picard, and J. P. Levy. 1989. Role of different lymphocyte subsets in human anti-viral T cell cultures. Cell. Immunol. 118:312.
39. - lymphocytes in human immunodeficiency virus-specific cytotoxic activity. J. Virol. 70:2022.
40. + T lymphocytes during HIV infection. J. Immunol. 156:2282.
41. - T lymphocytes by 4-1BB ligand. J. Immunol. 158:551.