메뉴 건너뛰기




Volumn 94, Issue 12, 1999, Pages 4358-4369

T-cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell-depleted or unmanipulated grafts: Evaluation of overall and antigen-specific T-cell repertoires

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CD4 ANTIGEN; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; METHOTREXATE;

EID: 0032762796     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.12.4358.424k02_4358_4369     Document Type: Article
Times cited : (71)

References (72)
  • 1
    • 0023094767 scopus 로고
    • The kinetics of immune reconstitution after human marrow grafting
    • Lum LG: The kinetics of immune reconstitution after human marrow grafting. Blood 63:369, 1987
    • (1987) Blood , vol.63 , pp. 369
    • Lum, L.G.1
  • 2
    • 0020642827 scopus 로고
    • Allogeneic bone-marrow transplantation
    • Storb R, Thomas ED: Allogeneic bone-marrow transplantation, Immunol Rev 71:77, 1983
    • (1983) Immunol Rev , vol.71 , pp. 77
    • Storb, R.1    Thomas, E.D.2
  • 3
    • 0020325364 scopus 로고
    • Pattern of T cell immune reconstitution following allogeneic bone marrow transplantation for acute hematological malignancy
    • Blume K: Pattern of T cell immune reconstitution following allogeneic bone marrow transplantation for acute hematological malignancy. Transplantation 34:96, 1982
    • (1982) Transplantation , vol.34 , pp. 96
    • Blume, K.1
  • 4
    • 0030796636 scopus 로고    scopus 로고
    • Immunological reconstitution following bone marrow transplantation
    • Parkman R, Weinberg KI. Immunological reconstitution following bone marrow transplantation. Immunol Rev 157.73, 1997
    • (1997) Immunol Rev , vol.157 , pp. 73
    • Parkman, R.1    Weinberg, K.I.2
  • 6
    • 0024600728 scopus 로고
    • Immune reconstitution following bone marrow transplantation: Comparison of recipients of T-cell depleted marrow with recipients of conventional grafts
    • Keever CA, Small TN, Flomenberg N, Heller G, Pekle K, Black P, Pecora A, Gillio A, Kernan NA, O'Reilly RJ: Immune reconstitution following bone marrow transplantation: Comparison of recipients of T-cell depleted marrow with recipients of conventional grafts. Blood 73:1340, 1989
    • (1989) Blood , vol.73 , pp. 1340
    • Keever, C.A.1    Small, T.N.2    Flomenberg, N.3    Heller, G.4    Pekle, K.5    Black, P.6    Pecora, A.7    Gillio, A.8    Kernan, N.A.9    O'Reilly, R.J.10
  • 7
    • 0029163414 scopus 로고
    • T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life
    • Storek J, Witherspoon RP, Storb R: T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Tranplant 16:413, 1995
    • (1995) Bone Marrow Tranplant , vol.16 , pp. 413
    • Storek, J.1    Witherspoon, R.P.2    Storb, R.3
  • 8
    • 0031042008 scopus 로고    scopus 로고
    • Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts
    • Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R: Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol 54:131, 1997
    • (1997) Am J Hematol , vol.54 , pp. 131
    • Storek, J.1    Gooley, T.2    Witherspoon, R.P.3    Sullivan, K.M.4    Storb, R.5
  • 9
    • 0026458601 scopus 로고
    • Thymic selection a matter of life and death
    • Von Boehmer H: Thymic selection a matter of life and death. Immunol Today 13:454, 1992
    • (1992) Immunol Today , vol.13 , pp. 454
    • Von Boehmer, H.1
  • 11
    • 0030806085 scopus 로고    scopus 로고
    • In thymic selection, peptide diversity gives and takes away
    • Bevan MJ: In thymic selection, peptide diversity gives and takes away. Immunity 7:175, 1997
    • (1997) Immunity , vol.7 , pp. 175
    • Bevan, M.J.1
  • 13
    • 0023818570 scopus 로고
    • Structure, organization, and polymorphism of murine and human T cell receptor α and β chain gene families
    • Wilson RK, Lai E, Concannon P, Barth RK, Hood LE: Structure, organization, and polymorphism of murine and human T cell receptor α and β chain gene families. Immunol Rev 101:149, 1988
    • (1988) Immunol Rev , vol.101 , pp. 149
    • Wilson, R.K.1    Lai, E.2    Concannon, P.3    Barth, R.K.4    Hood, L.E.5
  • 14
    • 2642648459 scopus 로고
    • The outline structure of the T cell receptor αβ receptor
    • Chotia C, Boswell DR, Lesk AM: The outline structure of the T cell receptor αβ receptor. EMBO J 7:3745, 1988
    • (1988) EMBO J , vol.7 , pp. 3745
    • Chotia, C.1    Boswell, D.R.2    Lesk, A.M.3
  • 15
    • 0028178077 scopus 로고
    • Non-random employment of Vβ6 and Jβ gene elements and conserved amino acid usage profiles in CDR3 regions of human fetal and adult TCR β chain rearrangements
    • Raaphorst FM, Kaijzel EL, van Tol MDJ, Vossen JM, van den Elsen PJ: Non-random employment of Vβ6 and Jβ gene elements and conserved amino acid usage profiles in CDR3 regions of human fetal and adult TCR β chain rearrangements. Int Immunol 6:1, 1993
    • (1993) Int Immunol , vol.6 , pp. 1
    • Raaphorst, F.M.1    Kaijzel, E.L.2    Van Tol, M.D.J.3    Vossen, J.M.4    Van Den Elsen, P.J.5
  • 20
    • 0029943897 scopus 로고    scopus 로고
    • Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited and prone to skewing
    • Mackall CI, Bare CV, Granger LA, Sharrow SO, Titus JA, Gress RE: Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited and prone to skewing. J Immunol 156:4609, 1996
    • (1996) J Immunol , vol.156 , pp. 4609
    • Mackall, C.I.1    Bare, C.V.2    Granger, L.A.3    Sharrow, S.O.4    Titus, J.A.5    Gress, R.E.6
  • 22
    • 0030913588 scopus 로고    scopus 로고
    • T cell-regeneration: All repertoires are not created equal
    • Mackall CL, Hakim FT, Gress RE: T cell-regeneration: All repertoires are not created equal. Immunol Today 18:245, 1997
    • (1997) Immunol Today , vol.18 , pp. 245
    • Mackall, C.L.1    Hakim, F.T.2    Gress, R.E.3
  • 23
    • 0030176389 scopus 로고    scopus 로고
    • T cell repertoire complexity after allogeneic bone marrow transplantation
    • Roux E, Helg C, Chapuis B, Jeannet M, Roosnek E: T cell repertoire complexity after allogeneic bone marrow transplantation. Hum Immunol 48:135, 1996
    • (1996) Hum Immunol , vol.48 , pp. 135
    • Roux, E.1    Helg, C.2    Chapuis, B.3    Jeannet, M.4    Roosnek, E.5
  • 24
    • 0028921427 scopus 로고
    • Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence
    • Pawelec G: Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech Ageing Dev 79:1, 1995
    • (1995) Mech Ageing Dev , vol.79 , pp. 1
    • Pawelec, G.1
  • 25
    • 0030727150 scopus 로고    scopus 로고
    • Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells
    • Brocker T: Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J Exp Med 186:1223. 1997
    • (1997) J Exp Med , vol.186 , pp. 1223
    • Brocker, T.1
  • 26
    • 0031766182 scopus 로고    scopus 로고
    • The organization of mature T cell pools
    • Tanchot C, Rocha B: The organization of mature T cell pools. Immunol Today 19:575, 1998
    • (1998) Immunol Today , vol.19 , pp. 575
    • Tanchot, C.1    Rocha, B.2
  • 29
    • 0023518554 scopus 로고
    • Pathology of the thymus after allogeneic bone marrow transplantation in man
    • Muller-Hermelink HK, Sale GE, Borisch B, Storb R: Pathology of the thymus after allogeneic bone marrow transplantation in man. Am J Pathol 129:242, 1987
    • (1987) Am J Pathol , vol.129 , pp. 242
    • Muller-Hermelink, H.K.1    Sale, G.E.2    Borisch, B.3    Storb, R.4
  • 30
    • 0029131501 scopus 로고
    • Intra-epithelial lymphocytes, evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium
    • Lundqvist C, Baranov V, Hammarstrom S, Athlin L, Hammarstrom M-L: Intra-epithelial lymphocytes, evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 7:1473, 1995
    • (1995) Int Immunol , vol.7 , pp. 1473
    • Lundqvist, C.1    Baranov, V.2    Hammarstrom, S.3    Athlin, L.4    Hammarstrom, M.-L.5
  • 31
    • 0029847625 scopus 로고    scopus 로고
    • RAG1, RAG2 and pre-T cell receptor a chain expression by adult human hepatic T cells: Evidence for extrathymic T cell maturation
    • Collins C, Norris S, McEntee G, Traynor O, Bruno L, von Boehmer H, Hegarty J, O'Farelly C: RAG1, RAG2 and pre-T cell receptor a chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation. Eur J Immunol 26:3114, 1996
    • (1996) Eur J Immunol , vol.26 , pp. 3114
    • Collins, C.1    Norris, S.2    McEntee, G.3    Traynor, O.4    Bruno, L.5    Von Boehmer, H.6    Hegarty, J.7    O'Farelly, C.8
  • 32
    • 0343320882 scopus 로고
    • Abrogation of histo-incompatibility barriers in Rhesus monkeys
    • Baum SJ, Ledney GD, Thierfelder S (eds): Basel, Switzerland, Karger
    • Wagemaker G, Heidt PJ, Merchav S, van Bekkum DW: Abrogation of histo-incompatibility barriers in Rhesus monkeys, in Baum SJ, Ledney GD, Thierfelder S (eds): Experimental Haematology Today. Basel, Switzerland, Karger. 1982, p 111
    • (1982) Experimental Haematology Today , pp. 111
    • Wagemaker, G.1    Heidt, P.J.2    Merchav, S.3    Van Bekkum, D.W.4
  • 38
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang J, Marcovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA: Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179:973, 1994
    • (1994) J Exp Med , vol.179 , pp. 973
    • Zhang, J.1    Marcovic-Plese, S.2    Lacet, B.3    Raus, J.4    Weiner, H.L.5    Hafler, D.A.6
  • 39
    • 0028220953 scopus 로고
    • Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping
    • Gorski J, Yassai M, Zhu X, Kissela B, Keever C, Flomenberg N: Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. J Immunol 152:5109, 1993
    • (1993) J Immunol , vol.152 , pp. 5109
    • Gorski, J.1    Yassai, M.2    Zhu, X.3    Kissela, B.4    Keever, C.5    Flomenberg, N.6
  • 40
    • 0033168349 scopus 로고    scopus 로고
    • Incomplete T-cell immune reconstitution in two major histocompatibility complex class II-deficiency/bare lymphocyte syndrome patients after HLA-identical sibling bone marrow transplantation
    • Godthelp BC, van Eggermond MCJA, Peijnenburg A, Tezcan I, van Lierde S, van Tol MJD, Vossen MJD, van den Elsen PJ: Incomplete T-cell immune reconstitution in two major histocompatibility complex class II-deficiency/bare lymphocyte syndrome patients after HLA-identical sibling bone marrow transplantation. Blood 94:348, 1999
    • (1999) Blood , vol.94 , pp. 348
    • Godthelp, B.C.1    Van Eggermond, M.C.J.A.2    Peijnenburg, A.3    Tezcan, I.4    Van Lierde, S.5    Van Tol, M.J.D.6    Vossen, M.J.D.7    Van Den Elsen, P.J.8
  • 41
    • 0032402158 scopus 로고    scopus 로고
    • Reconstitution of the T-cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants
    • Dumont-Girard F, Roux E, van Lier RA, Hale G, Helg, Chapuis B, Starobinski M, Roosnek E: Reconstitution of the T-cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants. Blood 92:4464, 1998
    • (1998) Blood , vol.92 , pp. 4464
    • Dumont-Girard, F.1    Roux, E.2    Van Lier, R.A.3    Hale, G.4    Helg5    Chapuis, B.6    Starobinski, M.7    Roosnek, E.8
  • 42
    • 0025354748 scopus 로고
    • Optimal conditions for directly sequencing double-stranded PCR products with Sequenase
    • Casanova J-L, Pannetier C, Jaulin C, Kourilsky P: Optimal conditions for directly sequencing double-stranded PCR products with Sequenase. Nucleic Acids Res 18:4028, 1990
    • (1990) Nucleic Acids Res , vol.18 , pp. 4028
    • Casanova, J.-L.1    Pannetier, C.2    Jaulin, C.3    Kourilsky, P.4
  • 43
    • 2642708403 scopus 로고    scopus 로고
    • Simultaneous detection of X and Y chromosomes by two-colour fluorescence in situ hybridisation in combination with immunophenotyping of single cells to document chimaerism after sex-mismatched bone marrow transplantation
    • Van Tol MDJ, Langlois van den Bergh R, Mesker W, Ouwerkerkvan Velzen MC, Vossen JM, Tanke HJ: Simultaneous detection of X and Y chromosomes by two-colour fluorescence in situ hybridisation in combination with immunophenotyping of single cells to document chimaerism after sex-mismatched bone marrow transplantation. Bone Marrow Transplant 21:497, 1998
    • (1998) Bone Marrow Transplant , vol.21 , pp. 497
    • Van Tol, M.D.J.1    Langlois Van Den Bergh, R.2    Mesker, W.3    Ouwerkerkvan Velzen, M.C.4    Vossen, J.M.5    Tanke, H.J.6
  • 45
    • 1842340825 scopus 로고
    • Organization and sequences of the diversity, joining and constant region genes of the human T-cell receptor β chain
    • Toyanaga B, Yoshikai Y, Vadasz V, Chin B, Mak TW: Organization and sequences of the diversity, joining and constant region genes of the human T-cell receptor β chain. Proc Natl Acad Sci USA 82:8624, 1985
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8624
    • Toyanaga, B.1    Yoshikai, Y.2    Vadasz, V.3    Chin, B.4    Mak, T.W.5
  • 49
    • 0031035896 scopus 로고    scopus 로고
    • Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation
    • Koehne G, Zeller W, Stockschlaeder M, Zander AR: Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 19:149, 1997
    • (1997) Bone Marrow Transplant , vol.19 , pp. 149
    • Koehne, G.1    Zeller, W.2    Stockschlaeder, M.3    Zander, A.R.4
  • 53
    • 0027221526 scopus 로고
    • + T cells contain cells with high levels of lymphocyte function-associated-antigen-1 expression, a phenotype of primed cells
    • + T cells contain cells with high levels of lymphocyte function-associated-antigen-1 expression, a phenotype of primed cells. J Immunol 150:429, 1993
    • (1993) J Immunol , vol.150 , pp. 429
    • Okumura, M.1    Fujii, Y.2    Inada, K.3    Nakahara, K.4    Matsuda, H.5
  • 55
    • 0023687670 scopus 로고
    • Abnormal distribution of T cell subsets in the thymus of cyclosporin A (CsA) treated mice
    • Hiramine C, Hojo K, Matsumoto H: Abnormal distribution of T cell subsets in the thymus of cyclosporin A (CsA) treated mice. Thymus 11:243, 1988
    • (1988) Thymus , vol.11 , pp. 243
    • Hiramine, C.1    Hojo, K.2    Matsumoto, H.3
  • 56
    • 0024392719 scopus 로고
    • The effects of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymic organ cultures treated with cyclosporin A
    • Kogushi A, Züniga-Pflücker JC, Sharrow SO, Kruisbeek AM, Shearer GM: The effects of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymic organ cultures treated with cyclosporin A. J Immunol 143.3134, 1989
    • (1989) J Immunol , vol.143 , pp. 3134
    • Kogushi, A.1    Züniga-Pflücker, J.C.2    Sharrow, S.O.3    Kruisbeek, A.M.4    Shearer, G.M.5
  • 58
    • 0030176090 scopus 로고    scopus 로고
    • T cell receptor clonal diversity following allogeneic marrow grafting
    • Akatsuka Y, Cerveny C, Hansen JA: T cell receptor clonal diversity following allogeneic marrow grafting. Hum Immunol 48:12, 1996
    • (1996) Hum Immunol , vol.48 , pp. 12
    • Akatsuka, Y.1    Cerveny, C.2    Hansen, J.A.3
  • 59
    • 0029922179 scopus 로고    scopus 로고
    • Analysis of T-cell repopulation after allogeneic bone marrow transplantation: Significant differences between recipients of T cell depleted and unmanipulated grafts
    • Roux E, Helg C, Dumont-Girard, Chapuis B, Jeannet M, Roosnek E: Analysis of T-cell repopulation after allogeneic bone marrow transplantation: Significant differences between recipients of T cell depleted and unmanipulated grafts. Blood 87:3984, 1996
    • (1996) Blood , vol.87 , pp. 3984
    • Roux, E.1    Helg, C.2    Dumont-Girard3    Chapuis, B.4    Jeannet, M.5    Roosnek, E.6
  • 60
    • 0029014308 scopus 로고
    • T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: Evidence for oligoclonal expansions in tumors and inflammatory diseases
    • Even J, Lim, A, Puisieux I, Ferradini L, Dietrich P-Y, Toubert A, Hercend T, Triebel F, Pannetier C, Kourilsky P: T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: Evidence for oligoclonal expansions in tumors and inflammatory diseases. Res Immunol 146:65, 1995
    • (1995) Res Immunol , vol.146 , pp. 65
    • Even, J.1    Lim, A.2    Puisieux, I.3    Ferradini, L.4    Dietrich, P.-Y.5    Toubert, A.6    Hercend, T.7    Triebel, F.8    Pannetier, C.9    Kourilsky, P.10
  • 62
    • 0028567520 scopus 로고
    • Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro
    • Masuko K, Kato T, Ikeda Y, Okubo M, Mizushima Y, Nishioka K, Yamamoto K: Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro. Int Immunol 6:1959, 1994
    • (1994) Int Immunol , vol.6 , pp. 1959
    • Masuko, K.1    Kato, T.2    Ikeda, Y.3    Okubo, M.4    Mizushima, Y.5    Nishioka, K.6    Yamamoto, K.7
  • 65
    • 0027527305 scopus 로고
    • Cyclosporin A and FK506: Molecular mechanisms of immunosuppression and probes for transplantation biology
    • Bierer BE, Holländer G, Fruman D, Burakoff SJ: Cyclosporin A and FK506: Molecular mechanisms of immunosuppression and probes for transplantation biology. Curr Opin Immunol 5:63,1993
    • (1993) Curr Opin Immunol , vol.5 , pp. 63
    • Bierer, B.E.1    Holländer, G.2    Fruman, D.3    Burakoff, S.J.4
  • 66
    • 0027988229 scopus 로고
    • Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory cells
    • Mousaki A, Rungger D: Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory cells. Blood 84:2612, 1994
    • (1994) Blood , vol.84 , pp. 2612
    • Mousaki, A.1    Rungger, D.2
  • 67
    • 0028323247 scopus 로고
    • Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T-lymphocyte clones reveals a limited TCR repertoire
    • Kalams SA, Johnson RP, Trocha AK, Dynan MJ, Ngo HS, D'Aquila RT, Kurnick JT, Walker BD: Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T-lymphocyte clones reveals a limited TCR repertoire. J Exp Med 179:1261, 1994
    • (1994) J Exp Med , vol.179 , pp. 1261
    • Kalams, S.A.1    Johnson, R.P.2    Trocha, A.K.3    Dynan, M.J.4    Ngo, H.S.5    D'Aquila, R.T.6    Kurnick, J.T.7    Walker, B.D.8
  • 70
    • 0032520770 scopus 로고    scopus 로고
    • A class I MHC-restricted response to a viral peptide is highly polyclonal despite stringent CDR3 selection: Implications for establishing memory T cell repertoires in real-world conditions
    • Naumov YN, Hogan KT, Naumova EN, Pagel JT, Gorski J: A class I MHC-restricted response to a viral peptide is highly polyclonal despite stringent CDR3 selection: Implications for establishing memory T cell repertoires in real-world conditions. J Immunol 160:2842, 1998
    • (1998) J Immunol , vol.160 , pp. 2842
    • Naumov, Y.N.1    Hogan, K.T.2    Naumova, E.N.3    Pagel, J.T.4    Gorski, J.5
  • 71
    • 0024439437 scopus 로고
    • Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells
    • Roberts JL, Volkman DJ, Buckley RH: Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells. J Immunol 143:1575, 1989
    • (1989) J Immunol , vol.143 , pp. 1575
    • Roberts, J.L.1    Volkman, D.J.2    Buckley, R.H.3
  • 72
    • 0029895686 scopus 로고    scopus 로고
    • Thymic involution with ageing obsolescence or good housekeeping
    • George AJT, Ritter MA: Thymic involution with ageing obsolescence or good housekeeping. Immunol Today 17:267, 1996
    • (1996) Immunol Today , vol.17 , pp. 267
    • George, A.J.T.1    Ritter, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.