Preferential Rearrangements of the T Cell Receptor-δ-Deleting Elements in Human T Cells

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1208-1216

  Verschuren, Martie C M ^a   Wolvers Tettero, Ingrid L M ^a   Breit, Timo M ^a   Noordzij, Jeroen ^a   Van Wering, Elisabeth R ^b   Van Dongen, Jacques J M ^a,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Dutch Childhood Leukemia Study Group   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELE; ARTICLE; CELL CULTURE; GENE DELETION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOLOGY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRENATAL DEVELOPMENT; REGULATORY SEQUENCE; SOUTHERN BLOTTING; T LYMPHOCYTE; THYMUS;

ALLELES; BASE SEQUENCE; BLOTTING, SOUTHERN; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, DELTA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; T-LYMPHOCYTES; THYMUS GLAND; TUMOR CELLS, CULTURED;

EID: 0031065162     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Raulet, D. H. 1989. The structure, function, and molecular genetics of the γ/δ̈ T cell receptor. Annu. Rev. Immunol. 7:175.
2. Van Dongen, J. J. M., and I. L. M. Wolvers-Tettero. 1991. Analysis of immunoglobulin and T cell receptor genes. I. Basic and technical aspects. Clin. Chim. Acta 198:1.
3. Schatz, D. G., M. A. Oettinger, and M. S. Schlissel. 1992. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 10:359.
4. Lewis, S. M. 1994. The mechanisms of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27.
5. Eastman, Q. M., T. M. J. Leu, and D. G. Schatz. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380:85.
6. Satyanarayana, K., S. Hata, P. Devlin, M. G. Roncarolo, J. E. De Vries, H. Spits, J. L. Strominger, and M. S. Krangel. 1988. Genomic organization of the human T-cell antigen-receptor αlδ locus. Proc. Natl. Acad. Sci. USA 85:8166.
7. De Villartay, J.-P., R. D. Hockett, D. Coran, S. J. Korsmeyer, and D. I. Cohen. 1988. Deletion of the human T-cell receptor δ-gene by a site-specific recombination. Nature 335:170.
8. Van Dongen, J. J. M., W. M. Comans-Bitter, I. L. M. Wolvers-Tettero, and J. Borst. 1990. Development of human T lymphocytes and their thymus-dependency. Thymus 16:207.
9. De Villartay, J.-P., D. Mossalayi, R. De Chasseval, A. Dalloul, and P. Debré. 1991. The differentiation of human pro-thymocytes along the TCR-α/β pathway in vitro is accompanied by the site-specific deletion of the TCR-δ locus. Int. Immunol. 3:1301.
10. Hockett, R. D. J., G. Nunez, and S. J. Korsmeyer. 1989. Evolutionary comparison of murine and human δ T-cell receptor deleting elements. New Biol. 1:266.
11. Breit, T. M., I. L. M. Wolvers-Tettero, A. J. J. C. Bogers, R. R. De Krijger, J. W. Wladimiroff, and J. J. M. Van Dongen. 1994. Rearrangements of the human TCRD-deleting elements. Immunogenetics 40:70.
12. Begley, C. G., P. D. Aplan, M. P. Davey, J.-P. De Villartay, D. I. Cohen, T. A. Waldmann, and I. R. Kirsch. 1989. Demonstration of δrec-pseudo Jα rearrangement with deletion of the δ locus in a human stem-cell leukemia. J. Exp. Med. 170:339.
13. Breit, T. M., I. L. M. Wolvers-Tettero, K. Hählen, E. R. Van Wering, and J. J. M. Van Dongen. 1991. Limited combinatorial repertoire of γδ T-cell receptors expressed by T-cell acute lymphoblastic leukemias. Leukemia 5:116.
14. Breit, T. M., I. L. M. Wolvers-Tettero, K. Hählen, E. R. Van Wering, and J. J. M. Van Dongen. 1991. Extensive junctional diversity of γδ T-cell receptors expressed by T-cell acute lymphoblastic leukemias: implications for the detection of minimal residual disease. Leukemia 5:1076.
15. Hara, J., Y. Takihara, K. Yumura-Yagi, S. Ishihara, A. Tawa, T. W. Mak, E. W. Gelfand, S. Okada, and K. Kawa-Ha. 1991. Differential usage of δ recombining element and Vδ genes during T-cell ontogeny. Blood 78:2075.
16. Van der Stoep, N., R. De Krijger, J. Bruining, F. Koning, and P. Van den Elsen. 1990. Analysis of early fetal T-cell receptor δ chain in humans. Immunogenetics 32:331.
17. Breit, T. M., I. L. M. Wolvers-Tettero, A. Beishuizen, M.-A. J. Verhoeven, E. R. Van Wering, and J. J. M. Van Dongen. 1993. Southern blot patterns, frequencies and junctional diversity of T-cell receptor δ gene rearrangements in acute lymphohlastic leukemia. Blood 82:3063.
18. Breit, T. M., and J. J. M. Van Dongen. 1994. Unravelling human T-cell receptor junctional region sequences. Thymus 22:177.
19. Koop, B. F., L. Rowen, K. Wang, C. L. Kuo, D. Seto, J. A. Lenstra, S. Howard, W. Shan, P. Deshpande, and L. Hood. 1994. The human T-cell receptor TCRAC/ TCRDC (Cα/Cδ) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19:478.
20. Burnett, R. C., R. Espinosa, T. B. Shows, R. L. Eddy, M. M. LeBeau, J. D. Rowley, and M. O. Diaz. 1993. Molecular analysis of a t(11;14)(q23;1) from a patient with null-cell acute lymphoblastic leukemia. Genes Chromosomes & Cancer 7:38.
21. Giachino, C., M. P. Rocci, M. Bottaro, G. Matullo, G. De Libero, and N. Migone. 1994. T cell receptor Vδ2-Cα transcripts are present in the thymus but virtually absent in the periphery. J. Immunol. 153:1637.
22. Minowada, J., K. Kohno, Y. Matsuo, H. G. Drexler, T. Ohnuma, W. J. Tax, and M. B. Brenner. 1989. Characteristics of 27 human T-cell leukemia cell lines with/without T-cell receptors of T3-Tiαβ or T3-Tiγδ complex. Haematol. Bluttransfus. 32:233.
23. Drexler, H. G., R. A. F. Macleod, A. Borkhardt, and J. W. G. Janssen. 1995. Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines. Leukemia 9:480.
24. Van Dongen, J. J. M., H. J. Adriaansen, and H. Hooijkaas. 1988. Immunophenotyping of leukaemias and non-Hodgkin's lymphomas: immunological markers and their CD codes. Neth. J. Med. 33:298.
25. De Villartay, J.-P., D. Lewis, R. Hockett, T. A. Waldmann, S. J. Korsmeyer, and D. I. Cohen. 1987. Deletional rearrangement in the human T-cell receptor α-chain locus. Proc. Natl. Acad. Sci. USA 84:86011.
26. Hockett, R. D., J.-P. De Villartay, K. Pollock, D. G. Poplack, D. I. Cohen, and S. J. Korsmeyer. 1988. Human T-cell antigen receptor (TCR) δ-chain locus and elements responsible for its deletion are within the TCR α-chain locus. Proc. Natl. Acad. Sci. USA 85:9694.
27. Krangel, M. S., H. Yssel, C. Brocklehurst, and H. Spits. 1990. A distinct wave of human T cell receptor γ/δ lymphocytes in the early fetal thymus: evidence for controlled gene rearrangements and cytokine production. J. Exp. Med. 172:847.
28. - γ/δ T cells. J. Exp. Med. 177:425.
29. McVay, L. D., S. R. Carding, K. Bottomly, and A. C. Hayday. 1991. Regulated expression and structure of T cell receptor γ/δ transcripts in human thymic ontogeny. EMBO J. 10:83.
30. Gauss, G. H., and M. R. Lieber. 1996. Mechanistic constraints on diversity in human V(D)J recombination. Mol. Cell. Biol. 16:258.
31. + peripheral lymphocyte subset. The Vδ1 gene segment is expressed with either Cα or Cδ. J. Exp. Med. 171:1171.
32. Sottini, A., L. Imberti, G. Fiordalisi, and D. Primi. 1991. Use of variable human Vδ genes to create functional T cell receptor a chain transcripts. Eur. J. Immunol. 21:2455.
33. Miossec, C., A. Caignard, L. Ferradini, S. Roman-Roman, F. Faure, H. Michalaki, F. Triebel, and T. Hercend. 1991. Molecular characterization of human T cell receptor α chains including a Vδ1-encoded variable segment. Eur. J. Immunol. 21:1061.
34. Peyrat, M. A., F. Davodeau, I. Houde, F. Romagne, A. Necker, C. Leget, J. P. Cervoni, N. Cerf-Bensussan, H. Vie, M. Bonneville, and M. M. Hallet. 1995. Repertoire analysis of human peripheral blood lymphocytes using a human Vδ3 region-specific monoclonal antibody. Characterization of dual T cell receptor (TCR) δ-chain expressors and αβ T cells expressing Vδ3JαCα-encoded TCR chains. J. Immunol. 155:3060.
35. Moss, P. A. H., W. M. C. Rosenberg, E. Zintzaras, and J. I. Bell. 1993. Characterization of the human T cell receptor a-chain repertoire and demonstration of a genetic influence on Vα usage. Eur. J. Immunol. 23:1153.
36. Loh, E. Y., S. Cwirla, A. T. Seranni, J. H. Phillips, and L. L. Lanier. 1988. Human T-cell-receptor δ chain: genomic organization, diversity, and expression in populations of cells. Proc. Natl. Acad. Sci. USA 85:9714.
37. Takihara, Y., D. Tkachuk, E. Michalopoulos, E. Champagne, J. Reimann, M. Minden, and T. W. Mak. 1988. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell δ-chain locus. Proc. Natl. Acad. Sci. USA 85:6097.
38. Dariavach, P., and M.-P. LeFranc. 1989. First genomic sequence of the human T-cell receptor δ2 gene (TRDV2). Nucleic Acids Res. 17:4880.
39. Hata, S., M. Clabby, P. Devlin, H. Spits, J. E. De Vries, and M. S. Krangel. 1989. Diversity and organization of human T cell receptor δ variable gene segments. J. Exp. Med. 169:41.