Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution

Lancet

Volumn 355, Issue 9218, 2000, Pages 1875-1881

  Douek, Daniel C ^a   Vescio, Robert A ^b   Betts, Michael R ^a   Brenchley, Jason M ^a   Hill, Brenna J ^a   Zhang, Lan ^b   Berenson, James R ^b   Collins, Robert H ^a   Koup, Richard A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; GRANULOCYTE COLONY STIMULATING FACTOR; PREDNISONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LYMPHOCYTE COUNT; LYMPHOPOIESIS; MULTICENTER STUDY; MULTIPLE MYELOMA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS FUNCTION;

EID: 0034720664     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)02293-5     Document Type: Article

References (31)

1. Keever C.A., Small T.N., Flomenberg N.et al. Immune reconstitution following bone marrow transplantation. comparison of recipients of T-cell depleted marrow with recipients of conventional marrow grafts Blood. 73:1989;1340-1350.
2. Bomberger C., Singh-Jairam M., Rodey G.et al. Lymphoid reconstitution after autologous PBSC transplantation with FACS-sorted CD34+ hematopoietic progenitors. Blood. 91:1998;2588-2600.
3. Weinberg K., Annett G., Kasbyap A., Lenarsky C., Forman S., Parkman R. The effect of thymic function on immunocompetence following bone marrow transplantation. Biol Blood Marrow Transplant. 1:1995;18-23.
4. Mackall C., Fleisher T., Brown M.et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 332:1995;143-149.
5. Storek J., Witherspoon R., Storb R. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant. 16:1995;416-425.
6. Hakim F., Cepeda R., Kaimei S.et al. Constraints on CD4 recovery postchemotherapy in adults. thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells Blood. 90:1997;3789-3798.
7. de Gast G., Verdonck L., Middledorp J.et al. Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft. Blood. 66:1985;428-431.
8. Heitger A., Neu N., Kern H.et al. Essential role of the thymus to reconstitute naïve (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation. Blood. 90:1997;850-857.
9. Mackall C., Fleisher T., Brown M.et al. Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 89:1997;3700-3707.
10. Small T.N., Papadopoulos E.B., Boulad F.et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation. effect of patient age and donor leukocyte infusions Blood. 93:1999;467-480.
11. Tough D.F., Sprent J. Turnover of naïve- and memory-phenotype T cells. J Exp Med. 179:1994;1127-1135.
12. Mclean A., Michie C. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci USA. 92:1995;3707-3711.
13. Soares M.V., Borthwick N.J., Maini M.K., Janossy G., Salmon M., Akbar A.N. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naïve repertoire. J Immunol. 161:1998;5909-5917.
14. Picker L., Treer J., Ferguson-Darnell B., Collins P., Buck D., Terstappen L. Control of lymphocyte recirculation in man. J Immunol. 150:1993;1105-1121.
15. Young J.L., Ramage J.M., Gaston J.S., Beverley P.C. In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naïve T cells. Eur J Immunol. 27:1997;2383-2390.
16. Livak F., Schatz D. T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Moll Cell Biol. 16:1996;609-618.
17. Douek D.C., McFarland R.D., Keiser P.H.et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:1998;690-695.
18. Vescio R., Schiller G., Stewart A.K.et al. Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. Blood. 93:1999;1858-1868.
19. Gorochov G., Debre P., Leblond V., Sadat-Sowti B., Sigaux F., Autran B. Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation. Blood. 83:1994;587-595.
20. Mackall C., Bare D., Granger L., Sharrow S., Titus J., Gress R. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing. J Immunol. 156:1996;4609-4616.
21. Mackall C., Punt J., Morgan P., Farr A., Gress R. Thymic function in young/old chimeras. substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution Eur J Immunol. 28:1998;1886-1893.
22. Dreger P., Viehmann K., Steinmann J., et al G.-C.S.F. mobilized peripheral blood progenitor cells for allogeneic transplantation. comparison of T cell depletion strategies using different CD34+ selection systems or CAMPATH-1 Exp Hematol. 23:1995;147-154.
23. Arstila T.P., Casrouge A., Baron V., Even J., Kanellopoulos J., Kourilsky P. A direct estimate of the human alphabeta T cell receptor diversity. Science. 286:1999;958-961.
24. Jamieson B.D., Douek D.C., Killian S.et al. Generation of functional thymocytes in the human adult. Immunity. 10:1999;569-575.
25. Saito H., Kanamori Y., Takemaori T.et al. Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science. 280:1998;275-278.
26. Sato K., Ohtsuka K., Hasegawa K.et al. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J Exp Med. 182:1995;759-767.
27. Garcia-Ojeda M., Dejbakhsh-Jones S., Weissman I., Strober S. An alternate pathway for T cell development supported by the bone marrow microenvironment. recapitulation of thymic maturation J Exp Med. 187:1998;1813-1823.
28. McCune J., Loftus R., Schmidt D.et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 101:1998;2301-2308.
29. Markert M.L., Boeck A., Hale L.P.et al. Transplantation of thymus tissue in complete DiGeorge syndrome. N Engl J Med. 341:1999;1180-1189.
30. Roux E., Helg C., Dumont-Girard F., Chapuis B., Jeannet M., Roosnek E. Analysis of T-cell repopopulation after allogeneic bone marrow transplantation. significant differences between recipients of T-cell depleted and unmanipulated grafts Blood. 87:1996;3984-3992.
31. Bolotin E., Smogorzewska M., Smith S., Widmer M., Weinberg K. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood. 88:1996;1887-1894.