Delayed recovery of CDR3 complexity of the T-cell receptor-β chain in recipients of allogeneic bone marrow transplants who had virus-associated interstitial pneumonia: Monitor of T-cell function by CDR3 spectratyping

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 1, 2000, Pages S32-S39

  Hirokawa, Makoto ^a   Horiuchi, Takahiro ^a   Kitabayashi, Atsushi ^a   Kawabata, Yoshinari ^a   Matsutani, Takaji ^a,b   Suzuki, Ryuji ^a,b   Chihara, Junichi ^a   Miura, Akira B ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marrow transplantation; Diversity; Spectratyping; T cell

Indexed keywords

COMPLEMENTARY DNA; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; AMINO ACID SEQUENCE; ARTICLE; CELL FUNCTION; CELL REGENERATION; CLINICAL ARTICLE; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOCOMPETENCE; INTERSTITIAL PNEUMONIA; MALE; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BONE MARROW TRANSPLANTATION; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOCOMPETENCE; IMMUNOGLOBULIN VARIABLE REGION; LUNG DISEASES, INTERSTITIAL; MALE; NORMAL DISTRIBUTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPECTROMETRY, FLUORESCENCE; T-LYMPHOCYTES;

EID: 0033927647     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.106638     Document Type: Article

References (23)

1. Meer JW, Guiot HF, Broek PJ, Furth R. Infections in bone marrow transplant recipients. Semin Hematol. 21:1984;123-140.
2. Zaia JA. Infections. In: Blume KG, Petz LD, editors. Clinical bone marrow transplantation. New York: Churchill Livingstone. 1983;131-176.
3. Lum LG. The kinetics of immune reconstitution after human marrow transplantation. Blood. 69:1987;369-380.
4. Parkman R, Weinberg K. Immunological reconstitution following hematopoietic stem cell transplantation. In: Thomas ED, Blume KG, Forman SJ, editors. Hematopoietic cell transplantation. Malden (MA): Blackwell Science. 1999;704-711.
5. Seddik M, Seemayer TA, Lapp WS. T cell functional defect associated with thymic epithelial cell injury induced by a graft-versus-host reaction. Transplantation. 29:1980;61-66.
6. Seddik M, Seemayer TA, Lapp WS. The graft-versus-host reaction and immune function. Transplantation. 37:1984;281-286.
7. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med. 314:1986;729-735.
8. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation. 18:1974;295-304.
9. Boeckh M, Bowden RA, Goodrich JM, Pettinger M, Meyers JD. Cytomegalovirus antigen detection in peripheral blood leukocytes after allogeneic marrow transplantation. Blood. 80:1992;1358-1364.
10. Yau JC, Dimopoulas MA, Huan SD, Tarrand JJ, Spencer V, Spitzer G. Prophylaxis of cytomegalovirus infection with ganciclovir in allogeneic marrow transplantation. Eur J Haematol. 47:1991;371-376.
11. Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci USA. 90:1993;4319-4323.
12. Cochet M, Pannetier C, Regnault A, Darche S, Leclerc C, Kourilsky P. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur J Immunol. 22:1992;2639-2647.
13. Pannetier C, Even J, Kourilsky P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today. 16:1995;176-181.
14. Matsutani T, Yoshioka T, Tsuruta Y, Iwagami S, Suzuki R. Analysis of TCRAV and TCRBV repertoires in healthy individuals by microplate hybridization assay. Hum Immunol. 56:1997;57-69.
15. Yoshioka T, Matsutani T, Iwagami S, Tsuruta Y, Kaneshige T, Toyosaki T. Quantitative analysis of the usage of human T cell receptor alpha and beta chain variable regions by reverse dot blot hybridization. J Immunol Methods. 201:1997;145-155.
16. Sullivan KM, Meyers JD, Flournoy N, Storb R, Thomas ED. Early and late interstitial pneumonia following human bone marrow transplantation. Int J Cell Cloning. 4:1986;107-121.
17. Meyers JD, Flournoy N, Thomas ED. Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years' experience. Rev Infect Dis. 4:1982;1119-1132.
18. Mackall CL, Hakim FT, Gress RE. T-cell regeneration: all repertoires are not created equal. Immunol Today. 18:1997;245-251.
19. Girard F, Roux E, van Lier RA, Hale G, Helg C, Chapuis B. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood. 92:1998;4464-4471.
20. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood. 82:1993;2585-2594.
21. + hematopoietic progenitors. Blood. 91:1998;2588-2600.
22. Gorski J, Yassai M, Zhu X, Kissella B, Keever C, Flomenberg N. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. J Immunol. 152:1994;5109-5119.
23. Small TN, Papadopoulos EB, Boulad F, Black P, Malaspina H, Childs BH. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 93:1999;467-480.