Distinct contributions of CD4+ and CD8+ naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors

Blood

Volumn 100, Issue 5, 2002, Pages 1915-1918

  Eyrich, Matthias ^a,b   Croner, Tanja ^a,b   Leiler, Christine ^a,b   Lang, Peter ^a,b   Bader, Peter ^a,b   Klingebiel, Thomas ^a,b   Niethammer, Dietrich ^a,b   Schlegel, Paul G ^a,b,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; DONOR; HELPER CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MEMORY CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; T LYMPHOCYTE SUBPOPULATION;

EID: 0036721356     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-11-0005     Document Type: Article

References (22)

1. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity
2. T-cell repertoire complexity after allogenelc bone marrow transplantation
3. T-cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell-depleted or unmanipulated grafts: Evaluation of overall and antigen-specific T-cell repertoires
4. + hematopeietic progenitors
5. A prospective analysis of the pattern of immune reconstitution in a paediatric cohort following transplantation of positively selected human leucocyte antigen-disparate haematopoietic stem cells from parental donors
6. Pathways of T-cell regeneration in mice and humans: Implications for bone marrow transplantation and immunotherapy
7. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
8. Improvements in repertoire analysis by CDR3 size spectratyping: Bifamily PCR
9. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: Correlation with immune status
10. Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimedsm
11. The organization of mature T-cell pools
12. + circulating alpha/beta T-cell repertoires are equally complex and are characterized by different levels of steady-state TCR expression
13. Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing
14. + T cells: Costimulatory requirements and role in memory formation
15. Cutting edge: Naive T cells masquerading as memory cells
16. Stable clonal expansion of T cells induced by bone marrow transplantation
17. + subset in normal human subjects
18. T-cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic-independent progeny
19. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
20. Enhancement of thymopoiesis after bone marrow transplant by in vivo interieukin-7
21. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation
22. Mixed hematopoietic chimerism after allogeneic bone marrow transplantation: The impact of quantitative PCR analysis for prediction of relapse and graft rejection in children