Human T Cell Leukemias with Continuous V(D)J Recombinase Activity for TCR-δ Gene Deletion

Journal of Immunology

Volumn 159, Issue 9, 1997, Pages 4341-4349

  Breit, Timo M ^a   Verschuren, Martie C M ^a   Wolvers Tettero, Ingrid L M ^a   Van Gastel Mol, Ellen J ^a   Hählen, Karel ^a   Van Dongen, Jacques J M ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; LYMPHOCYTE ANTIGEN RECEPTOR; RECOMBINASE;

ARTICLE; GENE DELETION; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGY; T CELL LEUKEMIA;

DNA NUCLEOTIDYLTRANSFERASES; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT, T-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; LEUKEMIA, T-CELL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; VDJ RECOMBINASES;

EID: 0031279132     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Foon, K. A., and R. F. Todd III. 1986. Immunologic classification of leukemia and lymphoma. Blood 68:1.
2. Van Dongen, J. J. M., and I. L. M. Wolvers-Tettero. 1991. Analysis of immunoglobulin and T cell receptor genes. I. Basic and technical aspects. Clin. Chim. Acta 198:1.
3. Breit, T. M., I. L. M. Wolvers-Tettero, and J. J. M. Van Dongen. 1994. Phenotypic and genotypic characteristics of human early T-cell differentiation: the T-cell acute lymphoblastic leukaemia model. Res. Immunol. 145:139.
4. Van Dongen, J. J. M., W. M. Comans-Bitter, I. L. M. Wolvers-Tettero, and J. Borst. 1990. Development of human T lymphocytes and their thymus dependency. Thymus 16:207.
5. Alt, F. W., and D. Baltimore. 1982. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl. Acad. Sci. USA 79:4118.
6. Lewis, S. M. 1994. The mechanisms of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27.
7. De Villartay, J.-P., R. D. Hockett, D. Coran, S. J. Korsmeyer, and D. I. Cohen. 1988. Deletion of the human T-cell receptor δ-gene by a site-specific recombination. Nature 335:170.
8. Hockett, R. D., J.-P. De Villartay, K. Pollock, D. G. Poplack, D. I. Cohen, and S. J. Korsmeyer. 1988. Human T-cell antigen receptor (TCR) δ-chain locus and elements responsible for its deletion are within the TCR α-chain locus. Proc. Natl. Acad. Sci. USA 85:9694.
9. Hockett, R. D. J., G. Nunez, and S. J. Korsmeyer. 1989. Evolutionary comparison of murine and human δ T-cell receptor deleting elements. New Biol. 1:266.
10. Isobe, M., G. Russo, F. G. Haluska, and C. M. Croce. 1988. Cloning of the gene encoding the δ subunit of the human T-cell receptor reveals its physical organization within the α-subunit locus and its involvement in chromosome translocations in T-cell malignancy. Proc. Natl. Acad. Sci. USA 85:3933.
11. De Villartay, J.-P., D. Lewis, R. Hockett, T. A. Waldmann, S. J. Korsmeyer, and D. I. Cohen. 1987. Deletional rearrangement in the human T-cell receptor α-chain locus. Proc. Natl. Acad. Sci. USA 84:8608.
12. Breit, T. M., I. L. M. Wolvers-Tettero, A. J. J. C. Bogers, R. R. De Krijger, J. W. Wladimiroff, and J. J. M. Van Dongen. 1994. Rearrangements of the human TCRD-deleting elements. Immunogenetics 40:70.
13. Verschuren, M. C. M., I. L. M. Wolvers-Tettero, T. M. Breit, J. Noordzij, E. R. Van Wering, and J. J. M. Van Dongen. 1997. Preferential rearrangements of the T cell receptor-δ-deleting elements in human T cells. J. Immunol. 158: 1208.
14. Breit, T. M., E. J. Mol, I. L. M. Wolvers-Tettero, W. D. Ludwig, E. R. van Wering, and J. J. M. van Dongen. 1993. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor αβ lineage: T cell receptor δ gene deletion mechanism affects multiple genes. J. Exp. Med. 177:965.
15. Brown, L., J. T. Cheng, Q. Chen, M. J. Siciliano, W. Crist, G. Buchanan, and R. Baer. 1990. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9:3343.
16. Aplan, P. D., D. P. Lombardi, A. M. Ginsberg, J. Cossman, V. L. Bertness, and I. R. Kirsch. 1990. Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science 250:1426.
17. Macintyre, E. A., L. Smit, J. Ritz, I. R. Kirsch, and J. L. Strominger. 1992. Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor αβ lineage. Blood 80:1511.
18. Breit, T. M., I. L. M. Wolvers-Tettero, and J. J. M. Van Dongen. 1994. Lineage specific demethylation of tal-1 gene breakpoint region determines the frequency of tal-1 deletions in αβ lineage T-cells. Oncogene 9:1847.
19. Verschuren, M. C. M., C. J. L. Van Bergen, E. J. Van Gastel-Mol, A. J. J. C. Bogers, and J. J. M. Van Dongen. 1996. A DNA binding protein in human thymocytes recognizes the TCR-δ deleting element ψJα. J. Immunol. 156:3806.
20. Minowada, J., K. Kohno, Y. Matsuo, H. G. Drexler, T. Ohnuma, W. J. Tax, and M. B. Brenner. 1989. Characteristics of 27 human T-cell leukemia cell lines with/without T-cell receptors of T3-Tiαβ or T3-Tiγδ complex. Haematol. Bluttransfus. 32:233.
21. Drexler, H. G., R. A. F. Macleod, A. Borkhardt, and J. W. G. Janssen. 1995. Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines. Leukemia 9:480.
22. Van Dongen, J. J. M., H. J. Adriaansen, and H. Hooijkaas. 1987. Immunological marker analysis of cells in the various hematopoietic differentiation stages and their malignant counterparts. In Application of Monoclonal Antibodies in Tumor Pathology. D. J. Ruiter, G. J. Fleuren, and S. O. Warnaar, eds. Martinus Nijhoff, Dordrecht, The Netherlands, p. 87.
23. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning, a Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
24. Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035.
25. Ichihara, Y., M. Hirai, and Y. Kurosawa. 1992. Sequence and chromosome assignment to 11p13-p12 of human RAG genes. Immunol. Lett. 33:277.
26. Koop, B. F., L. Rowen, K. Wang, C. L. Kuo, D. Seto, J. A. Lenstra, S. Howard, W. Shan, P. Deshpande, and L. Hood. 1994. The human T-cell receptor TCRAC/ TCRDC (Cα/Cδ) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19:478.
27. Breit, T. M., I. L. M. Wolvers-Tettero, A. Beishuizen, M.-A. J. Verhoeven, E. R. Van Wering, and J. J. M. Van Dongen. 1993. Southern blot patterns, frequencies and junctional diversity of T-cell receptor δ gene rearrangements in acute lymphoblastic leukemia. Blood 82:3063.
28. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
29. Benham, F. J., S. Hodgkinson, and K. E. Davies. 1984. A glyceraldehyde-3-phosphate dehydrogenase pseudogene on the short arm of the human X-chromosomes defines a multigene family. EMBO J. 3:2635.
30. Koning, H., M. R. M. Baert, R. De Groot, H. J. Neijens, and H. F. J. Savelkoul. 1995. Analysis of cytokine gene expression in stimulated T cells of small children by semi-quantitative PCR. Mediat. Inflamm. 4:196.
31. Breit, T. M., I. L. M. Wolvers-Tettero, K. Hählen, E. R. Van Wering, and J. J. M. Van Dongen. 1991. Extensive junctional diversity of γδ T-cell receptors expressed by T-cell acute lymphoblastic leukemias: implications for the detection of minimal residual disease. Leukemia 5:1076.
32. Hochstenbach, F., and M. B. Brenner. 1989. T-cell receptor δ-chain can substitute for α to form a βδ heterodimer. Nature 340:562.
33. Hochstenbach, F., and M. B. Brenner. 1990. Newly identified γδ and βδ T-cell receptors. J. Clin. Immunol. 10:1.
34. Livak, F., and D. G. Schatz. 1996. T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16:609.
35. + T-lymphocytes associated with neutropenia and trombocytopenia. Leukemia 6:410.
36. Van Dongen, J. J. M., T. M. Breit, H. J. Adriaansen, A. Beishuizen, and H. Hooijkaas. 1992. Detection of minimal residual disease in acute leukemia by immunological marker analysis and polymerase chain reaction. Leukemia 6(Suppl. 1):47.
37. De Villartay, J.-P., D. Mossalayi, R. De Chasseval, A. Dalloul, and P. Debré. 1991. The differentiation of human pro-thymocytes along the TCR-αβ pathway in vitro is accompanied by the site-specific deletion of the TCR-δ locus. Int. Immunol. 3:1301.
38. De Villartay, J. P., A. B. Pullman, R. Andrade, E. Tschachler, O. Colamenici, L. Neckers, D. I. Cohen, and J. Cossman. 1989. γδ lineage relationship within a consecutive series of human precursor T-cell neoplasms. Blood 74:2508.
39. Villey, I., D. Caillol, F. Selz, P. Ferrier, and J. P. De Villartay. 1996. Defect in rearrangements of the most 5′ TCR-Jα following targeted deletion of T early α (TEA): implications for TCR α locus accessibility. Immunity 5:331.
40. Bird, J., N. Galili, M. Link, D. Stites, and J. Sklar. 1988. Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J. Exp. Med. 168:229.
41. Beishuizen, A., K. Hählen, A. Hagemeijer, M. A. J. Verhoeven, H. Hooijkaas, H. J. Adriaansen, I. L. M. Wolvers-Tettero, E. R. Van Wering, and J. J. M. Van Dongen. 1991. Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia 5:657.
42. Hansen-Hagge, T. E., S. Yokota, H. J. Reuter, K. Schwarz, and C. R. Bartram. 1992. Human common acute lymphoblastic leukemia-derived cell lines are competent to recombine their T-cell receptor δ/α regions along a hierarchically ordered pathway. Blood 80:2353.