-
1
-
-
0037082324
-
Target validation of G-protein coupled receptors
-
A. Wise Target validation of G-protein coupled receptors Drug Discov. Today 7 2002 235 246
-
(2002)
Drug Discov. Today
, vol.7
, pp. 235-246
-
-
Wise, A.1
-
2
-
-
2142851264
-
Lysophospholipid receptors: Signaling and biology
-
I. Ishii Lysophospholipid receptors: signaling and biology Annu. Rev. Biochem. 73 2004 321 354
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 321-354
-
-
Ishii, I.1
-
3
-
-
2442658976
-
Lysophospholipid G protein-coupled receptors
-
B. Anliker, and J. Chun Lysophospholipid G protein-coupled receptors J. Biol. Chem. 279 2004 20555 20558
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20555-20558
-
-
Anliker, B.1
Chun, J.2
-
4
-
-
0038004740
-
Targeting JNK for therapeutic benefit: From junk to gold?
-
A.M. Manning, and R.J. Davis Targeting JNK for therapeutic benefit: from junk to gold? Nat. Rev. Drug Discov. 2 2003 554 565
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 554-565
-
-
Manning, A.M.1
Davis, R.J.2
-
6
-
-
18944372230
-
Rho kinase, a promising drug target for neurological disorders
-
B.K. Mueller Rho kinase, a promising drug target for neurological disorders Nat. Rev. Drug Discov. 4 2005 387 398
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 387-398
-
-
Mueller, B.K.1
-
7
-
-
0036356038
-
Sphingosine kinases: A novel family of lipid kinases
-
H. Liu Sphingosine kinases: a novel family of lipid kinases Prog. Nucleic Acid Res. Mol. Biol. 71 2002 493 511
-
(2002)
Prog. Nucleic Acid Res. Mol. Biol.
, vol.71
, pp. 493-511
-
-
Liu, H.1
-
8
-
-
20944443148
-
Organ transplantation - How much of the promise has been realized?
-
R.I. Lechler Organ transplantation - how much of the promise has been realized? Nat. Med. 11 2005 605 613
-
(2005)
Nat. Med.
, vol.11
, pp. 605-613
-
-
Lechler, R.I.1
-
9
-
-
0028372227
-
Fungal metabolites. Part 11. a potent immunosuppressive activity found in Isaria sinclairii metabolite
-
T. Fujita Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite J. Antibiot. (Tokyo) 47 1994 208 215
-
(1994)
J. Antibiot. (Tokyo)
, vol.47
, pp. 208-215
-
-
Fujita, T.1
-
10
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
V. Brinkmann The immune modulator FTY720 targets sphingosine 1-phosphate receptors J. Biol. Chem. 277 2002 21453 21457
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
-
11
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
S. Mandala Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists Science 296 2002 346 349
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
-
12
-
-
30044441314
-
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
-
(in press)
-
Wei, S.H. et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. (in press)
-
Nat. Immunol.
-
-
Wei, S.H.1
-
13
-
-
3242796768
-
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
-
G. Cinamon Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone Nat. Immunol. 5 2004 713 720
-
(2004)
Nat. Immunol.
, vol.5
, pp. 713-720
-
-
Cinamon, G.1
-
14
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
M. Matloubian Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature 427 2004 355 360
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
-
15
-
-
2442561611
-
1, on T-cells controls thymic emigration
-
1, on T-cells controls thymic emigration J. Biol. Chem. 279 2004 15396 15401
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15396-15401
-
-
Allende, M.L.1
-
16
-
-
2442679391
-
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors
-
M.H. Graler, and E.J. Goetzl The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors FASEB J. 18 2004 551 553
-
(2004)
FASEB J.
, vol.18
, pp. 551-553
-
-
Graler, M.H.1
Goetzl, E.J.2
-
17
-
-
0034120178
-
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
-
D.D. Pinschewer FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory J. Immunol. 164 2000 5761 5770
-
(2000)
J. Immunol.
, vol.164
, pp. 5761-5770
-
-
Pinschewer, D.D.1
-
18
-
-
11144353922
-
3, respectively, regulate lymphocyte recirculation and heart rate
-
3, respectively, regulate lymphocyte recirculation and heart rate J. Biol. Chem. 279 2004 13839 13848
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13839-13848
-
-
Sanna, M.G.1
-
19
-
-
0036773971
-
FTY720: Targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
-
V. Brinkmann, and K.R. Lynch FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity Curr. Opin. Immunol. 14 2002 569 575
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 569-575
-
-
Brinkmann, V.1
Lynch, K.R.2
-
20
-
-
0037379202
-
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment
-
M. Fujino Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment J. Pharmacol. Exp. Ther. 305 2003 70 77
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, pp. 70-77
-
-
Fujino, M.1
-
21
-
-
3242683494
-
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
-
M. Webb Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice J. Neuroimmunol. 153 2004 108 121
-
(2004)
J. Neuroimmunol.
, vol.153
, pp. 108-121
-
-
Webb, M.1
-
22
-
-
0036830526
-
Thalamic neurodegeneration in multiple sclerosis
-
A. Cifelli Thalamic neurodegeneration in multiple sclerosis Ann. Neurol. 52 2002 650 653
-
(2002)
Ann. Neurol.
, vol.52
, pp. 650-653
-
-
Cifelli, A.1
-
23
-
-
0035941415
-
Sphingolipid mediators in cardiovascular cell biology and pathology
-
T. Levade Sphingolipid mediators in cardiovascular cell biology and pathology Circ. Res. 89 2001 957 968
-
(2001)
Circ. Res.
, vol.89
, pp. 957-968
-
-
Levade, T.1
-
24
-
-
0037704148
-
Lipid receptors in cardiovascular development
-
N. Osborne, and D.Y. Stainier Lipid receptors in cardiovascular development Annu. Rev. Physiol. 65 2003 23 43
-
(2003)
Annu. Rev. Physiol.
, vol.65
, pp. 23-43
-
-
Osborne, N.1
Stainier, D.Y.2
-
25
-
-
0033783522
-
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
-
Y. Liu Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation J. Clin. Invest. 106 2000 951 961
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 951-961
-
-
Liu, Y.1
-
26
-
-
0242411518
-
1 acts within endothelial cells to regulate vascular maturation
-
1 acts within endothelial cells to regulate vascular maturation Blood 102 2003 3665 3667
-
(2003)
Blood
, vol.102
, pp. 3665-3667
-
-
Allende, M.L.1
-
27
-
-
3142744111
-
3 function coordinately during embryonic angiogenesis
-
3 function coordinately during embryonic angiogenesis J. Biol. Chem. 279 2004 29367 29373
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 29367-29373
-
-
Kono, M.1
-
28
-
-
23944450417
-
Regulation of vascular reactivity by established and emerging GPCRs
-
J.J. Maguire, and A.P. Davenport Regulation of vascular reactivity by established and emerging GPCRs Trends Pharmacol. Sci. 26 2005 448 454
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 448-454
-
-
Maguire, J.J.1
Davenport, A.P.2
-
29
-
-
0037162054
-
Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate
-
W. Siess Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate Biochim. Biophys. Acta 1582 2002 204 215
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, pp. 204-215
-
-
Siess, W.1
-
30
-
-
0043020630
-
Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques
-
E. Rother Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques Circulation 108 2003 741 747
-
(2003)
Circulation
, vol.108
, pp. 741-747
-
-
Rother, E.1
-
31
-
-
0035860831
-
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
-
M.J. Kluk, and T. Hla Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration Circ. Res. 89 2001 496 502
-
(2001)
Circ. Res.
, vol.89
, pp. 496-502
-
-
Kluk, M.J.1
Hla, T.2
-
32
-
-
0035853107
-
Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation
-
D. Zohlnhofer Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: detection of FK506-binding protein 12 upregulation Circulation 103 2001 1396 1402
-
(2001)
Circulation
, vol.103
, pp. 1396-1402
-
-
Zohlnhofer, D.1
-
33
-
-
0037178737
-
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: Differential role in vasoconstriction
-
F. Coussin Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction Circ. Res. 91 2002 151 157
-
(2002)
Circ. Res.
, vol.91
, pp. 151-157
-
-
Coussin, F.1
-
34
-
-
0038730511
-
3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate
-
3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate Eur. J. Pharmacol. 469 2003 125 134
-
(2003)
Eur. J. Pharmacol.
, vol.469
, pp. 125-134
-
-
Salomone, S.1
-
38
-
-
0344585385
-
Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720
-
E. Sawicka Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720 J. Immunol. 171 2003 6206 6214
-
(2003)
J. Immunol.
, vol.171
, pp. 6206-6214
-
-
Sawicka, E.1
-
39
-
-
5644287793
-
In vitro and in vivo modulation of vascular barrier integrity by sphingosine1-phosphate: Mechanistic insights
-
B. McVerry, and J. Garcia In vitro and in vivo modulation of vascular barrier integrity by sphingosine1-phosphate: mechanistic insights Cell. Signal. 17 2005 131 139
-
(2005)
Cell. Signal.
, vol.17
, pp. 131-139
-
-
McVerry, B.1
Garcia, J.2
-
40
-
-
0036285240
-
Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model
-
K. Konishi Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model J. Heart Lung Transplant. 21 2002 692 700
-
(2002)
J. Heart Lung Transplant.
, vol.21
, pp. 692-700
-
-
Konishi, K.1
-
41
-
-
0036035993
-
The roles of sphingosine-1-phosphate in asthma
-
P.S. Jolly The roles of sphingosine-1-phosphate in asthma Mol. Immunol. 38 2002 1239 1245
-
(2002)
Mol. Immunol.
, vol.38
, pp. 1239-1245
-
-
Jolly, P.S.1
-
42
-
-
0035348292
-
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
-
A.J. Ammit Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma FASEB J. 15 2001 1212 1214
-
(2001)
FASEB J.
, vol.15
, pp. 1212-1214
-
-
Ammit, A.J.1
-
43
-
-
0036738085
-
Sphingosine 1-phosphate as a therapeutic agent
-
S. Spiegel, and R. Kolesnick Sphingosine 1-phosphate as a therapeutic agent Leukemia 16 2002 1596 1602
-
(2002)
Leukemia
, vol.16
, pp. 1596-1602
-
-
Spiegel, S.1
Kolesnick, R.2
-
44
-
-
0034799675
-
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
-
J.G. Garcia Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement J. Clin. Invest. 108 2001 689 701
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 689-701
-
-
Garcia, J.G.1
-
45
-
-
21544473152
-
3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF
-
3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF Proc. Natl. Acad. Sci. U. S. A. 102 2005 9270 9275
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 9270-9275
-
-
Gon, Y.1
-
46
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
H. Azuma Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models Cancer Res. 62 2002 1410 1419
-
(2002)
Cancer Res.
, vol.62
, pp. 1410-1419
-
-
Azuma, H.1
-
47
-
-
10344231428
-
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation
-
T.K. Lee FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation Carcinogenesis 25 2004 2397 2405
-
(2004)
Carcinogenesis
, vol.25
, pp. 2397-2405
-
-
Lee, T.K.1
-
48
-
-
17844382139
-
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway
-
M. Yang G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway Proc. Natl. Acad. Sci. U. S. A. 102 2005 6027 6032
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 6027-6032
-
-
Yang, M.1
-
49
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
P. Xia An oncogenic role of sphingosine kinase Curr. Biol. 10 2000 1527 1530
-
(2000)
Curr. Biol.
, vol.10
, pp. 1527-1530
-
-
Xia, P.1
-
50
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
K.J. French Discovery and evaluation of inhibitors of human sphingosine kinase Cancer Res. 63 2003 5962 5969
-
(2003)
Cancer Res.
, vol.63
, pp. 5962-5969
-
-
French, K.J.1
-
51
-
-
0042887042
-
The emerging role of lysophosphatidic acid in cancer
-
G.B. Mills, and W.H. Moolenaar The emerging role of lysophosphatidic acid in cancer Nat. Rev. Cancer 3 2003 582 591
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 582-591
-
-
Mills, G.B.1
Moolenaar, W.H.2
-
52
-
-
0037131366
-
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
-
A. Tokumura Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase J. Biol. Chem. 277 2002 39436 39442
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39436-39442
-
-
Tokumura, A.1
-
53
-
-
1542359873
-
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
-
M. Umezu-Goto Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production J. Cell Biol. 158 2002 227 233
-
(2002)
J. Cell Biol.
, vol.158
, pp. 227-233
-
-
Umezu-Goto, M.1
-
54
-
-
23844465897
-
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D
-
S. Jansen Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D J. Cell Sci. 118 2005 3081 3089
-
(2005)
J. Cell Sci.
, vol.118
, pp. 3081-3089
-
-
Jansen, S.1
-
55
-
-
0034642507
-
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells
-
S.W. Nam Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells Oncogene 19 2000 241 247
-
(2000)
Oncogene
, vol.19
, pp. 241-247
-
-
Nam, S.W.1
-
56
-
-
0035884290
-
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor
-
S.W. Nam Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor Cancer Res. 61 2001 6938 6944
-
(2001)
Cancer Res.
, vol.61
, pp. 6938-6944
-
-
Nam, S.W.1
-
57
-
-
10744223639
-
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1
-
T. Yamada Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1 J. Biol. Chem. 279 2004 6595 6605
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 6595-6605
-
-
Yamada, T.1
-
58
-
-
0037134949
-
Plasma lysophosphatidic acid concentration and ovarian cancer
-
D.L. Baker Plasma lysophosphatidic acid concentration and ovarian cancer J. Am. Med. Assoc. 287 2002 3081 3082
-
(2002)
J. Am. Med. Assoc.
, vol.287
, pp. 3081-3082
-
-
Baker, D.L.1
-
59
-
-
3142660497
-
Lysophospholipids are potential biomarkers of ovarian cancer
-
R. Sutphen Lysophospholipids are potential biomarkers of ovarian cancer Cancer Epidemiol. Biomarkers Prev. 13 2004 1185 1191
-
(2004)
Cancer Epidemiol. Biomarkers Prev.
, vol.13
, pp. 1185-1191
-
-
Sutphen, R.1
-
60
-
-
0036196268
-
Lysophosphatidic acid and its role in reproduction
-
L.T. Budnik, and A.K. Mukhopadhyay Lysophosphatidic acid and its role in reproduction Biol. Reprod. 66 2002 859 865
-
(2002)
Biol. Reprod.
, vol.66
, pp. 859-865
-
-
Budnik, L.T.1
Mukhopadhyay, A.K.2
-
61
-
-
3142685946
-
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
-
M. Inoue Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling Nat. Med. 10 2004 712 718
-
(2004)
Nat. Med.
, vol.10
, pp. 712-718
-
-
Inoue, M.1
-
62
-
-
0033955969
-
Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission
-
K. Renback Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission Mol. Brain Res. 75 2000 350 354
-
(2000)
Mol. Brain Res.
, vol.75
, pp. 350-354
-
-
Renback, K.1
-
63
-
-
0344417883
-
Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice
-
K. Renback Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice Neurosci. Lett. 270 1999 59 61
-
(1999)
Neurosci. Lett.
, vol.270
, pp. 59-61
-
-
Renback, K.1
-
64
-
-
0031963295
-
Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression
-
S. Love Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression Brain Pathol. 8 1998 1 11
-
(1998)
Brain Pathol.
, vol.8
, pp. 1-11
-
-
Love, S.1
-
65
-
-
0034981484
-
Schizophrenia as a neurodevelopmental disorder
-
R.M. Bilder Schizophrenia as a neurodevelopmental disorder Curr. Opin. Pyschiatry 14 2001 9 15
-
(2001)
Curr. Opin. Pyschiatry
, vol.14
, pp. 9-15
-
-
Bilder, R.M.1
-
66
-
-
0024583797
-
Quantification, characterization and fatty acid composition of lysophosphatidic acid in different rat tissues
-
A.K. Das, and A.K. Hajra Quantification, characterization and fatty acid composition of lysophosphatidic acid in different rat tissues Lipids 24 1989 329 333
-
(1989)
Lipids
, vol.24
, pp. 329-333
-
-
Das, A.K.1
Hajra, A.K.2
-
67
-
-
0031042001
-
Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues
-
Y. Yatomi Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues FEBS Lett. 404 1997 173 174
-
(1997)
FEBS Lett.
, vol.404
, pp. 173-174
-
-
Yatomi, Y.1
-
68
-
-
0034551689
-
Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology
-
N. Fukushima Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology Dev. Biol. 228 2000 6 18
-
(2000)
Dev. Biol.
, vol.228
, pp. 6-18
-
-
Fukushima, N.1
-
69
-
-
0028849449
-
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)
-
H. Kawagoe Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2) Genomics 30 1995 380 384
-
(1995)
Genomics
, vol.30
, pp. 380-384
-
-
Kawagoe, H.1
-
70
-
-
0037201937
-
Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis
-
C. McGiffert Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis FEBS Lett. 531 2002 103 108
-
(2002)
FEBS Lett.
, vol.531
, pp. 103-108
-
-
McGiffert, C.1
-
71
-
-
0032494278
-
Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain
-
J.A. Weiner Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain J. Comp. Neurol. 398 1998 587 598
-
(1998)
J. Comp. Neurol.
, vol.398
, pp. 587-598
-
-
Weiner, J.A.1
-
72
-
-
0034162958
-
Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA
-
J.J. Contos, and J. Chun Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA Genomics 64 2000 155 169
-
(2000)
Genomics
, vol.64
, pp. 155-169
-
-
Contos, J.J.1
Chun, J.2
-
73
-
-
0344011597
-
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
-
M.A. Kingsbury Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding Nat. Neurosci. 6 2003 1292 1299
-
(2003)
Nat. Neurosci.
, vol.6
, pp. 1292-1299
-
-
Kingsbury, M.A.1
-
74
-
-
0034700050
-
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
-
J.J. Contos Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior Proc. Natl. Acad. Sci. U. S. A. 97 2000 13384 13389
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 13384-13389
-
-
Contos, J.J.1
-
76
-
-
0345863390
-
LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease
-
S.M. Harrison LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease Mol. Cell. Neurosci. 24 2003 1170 1179
-
(2003)
Mol. Cell. Neurosci.
, vol.24
, pp. 1170-1179
-
-
Harrison, S.M.1
-
77
-
-
0026581360
-
Gating and habituation of the startle reflex in schizophrenic patients
-
D.L. Braff Gating and habituation of the startle reflex in schizophrenic patients Arch. Gen. Psychiatry 49 1992 206 215
-
(1992)
Arch. Gen. Psychiatry
, vol.49
, pp. 206-215
-
-
Braff, D.L.1
-
78
-
-
2542451853
-
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
-
G. Corfas Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia Nat. Neurosci. 7 2004 575 580
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 575-580
-
-
Corfas, G.1
-
79
-
-
0035836642
-
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
-
Y. Hakak Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia Proc. Natl. Acad. Sci. U. S. A. 98 2001 4746 4751
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4746-4751
-
-
Hakak, Y.1
-
80
-
-
0031927229
-
A rat G protein-coupled receptor selectively expressed in myelin-forming cells
-
J. Allard A rat G protein-coupled receptor selectively expressed in myelin-forming cells Eur. J. Neurosci. 10 1998 1045 1053
-
(1998)
Eur. J. Neurosci.
, vol.10
, pp. 1045-1053
-
-
Allard, J.1
-
81
-
-
18344397194
-
3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
-
3-mediated lysophosphatidic acid signalling in embryo implantation and spacing Nature 435 2005 104 108
-
(2005)
Nature
, vol.435
, pp. 104-108
-
-
Ye, X.1
-
82
-
-
0033034459
-
Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of in vitro fertilization patients
-
A. Tokumura Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of in vitro fertilization patients Biol. Reprod. 61 1999 195 199
-
(1999)
Biol. Reprod.
, vol.61
, pp. 195-199
-
-
Tokumura, A.1
-
83
-
-
0033786639
-
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
-
Y. Morita Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy Nat. Med. 6 2000 1109 1114
-
(2000)
Nat. Med.
, vol.6
, pp. 1109-1114
-
-
Morita, Y.1
-
84
-
-
0034102433
-
Sphingolipid regulation of female gonadal cell apoptosis
-
Y. Morita, and J.L. Tilly Sphingolipid regulation of female gonadal cell apoptosis Ann. N. Y. Acad. Sci. 905 2000 209 220
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.905
, pp. 209-220
-
-
Morita, Y.1
Tilly, J.L.2
-
85
-
-
0037203319
-
Sphingolipids, apoptosis, cancer treatments and the ovary: Investigating a crime against female fertility
-
J.L. Tilly, and R.N. Kolesnick Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility Biochim. Biophys. Acta 1585 2002 135 138
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, pp. 135-138
-
-
Tilly, J.L.1
Kolesnick, R.N.2
-
86
-
-
0034926280
-
Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase
-
W. Gogarten Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase Biol. Reprod. 65 2001 401 406
-
(2001)
Biol. Reprod.
, vol.65
, pp. 401-406
-
-
Gogarten, W.1
-
87
-
-
0018909989
-
Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregnant rats
-
A. Tokumura Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregnant rats Arch. Int. Pharmacodyn. Ther. 245 1980 74 83
-
(1980)
Arch. Int. Pharmacodyn. Ther.
, vol.245
, pp. 74-83
-
-
Tokumura, A.1
-
88
-
-
0017366933
-
Evidence for a role for prosaglandins in the initiation of blastocyst implantation in the rat
-
T.G. Kennedy Evidence for a role for prosaglandins in the initiation of blastocyst implantation in the rat Biol. Reprod. 16 1977 286 291
-
(1977)
Biol. Reprod.
, vol.16
, pp. 286-291
-
-
Kennedy, T.G.1
-
89
-
-
0022293197
-
Involvement of prostaglandins in implantation in the pregnant mouse
-
K. Kinoshita Involvement of prostaglandins in implantation in the pregnant mouse Adv. Prostaglandin Thromboxane Leukot. Res. 15 1985 605 607
-
(1985)
Adv. Prostaglandin Thromboxane Leukot. Res.
, vol.15
, pp. 605-607
-
-
Kinoshita, K.1
-
90
-
-
0033600761
-
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
-
K. Bandoh Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid J. Biol. Chem. 274 1999 27776 27785
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27776-27785
-
-
Bandoh, K.1
-
91
-
-
18244420024
-
Role of phospholipases during sperm acrosomal exocytosis
-
E.R. Roldan Role of phospholipases during sperm acrosomal exocytosis Front. Biosci. 3 1998 D1109 D1119
-
(1998)
Front. Biosci.
, vol.3
-
-
Roldan, E.R.1
-
92
-
-
0346996444
-
Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level
-
J. Yue Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level Cell. Signal. 16 2004 385 399
-
(2004)
Cell. Signal.
, vol.16
, pp. 385-399
-
-
Yue, J.1
-
93
-
-
2342430250
-
Obesity, insulin resistance, and cardiovascular disease
-
G. Reaven Obesity, insulin resistance, and cardiovascular disease Recent Prog. Horm. Res. 59 2004 207 223
-
(2004)
Recent Prog. Horm. Res.
, vol.59
, pp. 207-223
-
-
Reaven, G.1
-
94
-
-
13844314223
-
Fat cells: Afferent and efferent messages define new approaches to treat obesity
-
M. Lafontan Fat cells: afferent and efferent messages define new approaches to treat obesity Annu. Rev. Pharmacol. Toxicol. 45 2005 119 146
-
(2005)
Annu. Rev. Pharmacol. Toxicol.
, vol.45
, pp. 119-146
-
-
Lafontan, M.1
-
95
-
-
0035004560
-
Lysophosphatidic acid synthesis and release
-
C. Pages Lysophosphatidic acid synthesis and release Prostaglandins Other Lipid Mediat. 64 2001 1 10
-
(2001)
Prostaglandins Other Lipid Mediat.
, vol.64
, pp. 1-10
-
-
Pages, C.1
-
96
-
-
17644413626
-
Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor γ2
-
M.F. Simon Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor γ2 J. Biol. Chem. 280 2005 14656 14662
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14656-14662
-
-
Simon, M.F.1
-
97
-
-
0038043168
-
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity
-
G. Ferry Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity J. Biol. Chem. 278 2003 18162 18169
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18162-18169
-
-
Ferry, G.1
-
98
-
-
0037422595
-
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
-
T.M. McIntyre Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist Proc. Natl. Acad. Sci. U. S. A. 100 2003 131 136
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 131-136
-
-
McIntyre, T.M.1
-
99
-
-
0035966064
-
1 (EDG2) phospholipid growth factor receptors
-
1 (EDG2) phospholipid growth factor receptors J. Biol. Chem. 276 2001 49213 49220
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 49213-49220
-
-
Wang, D.A.1
-
100
-
-
0141570981
-
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
-
H. Ohta Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors Mol. Pharmacol. 64 2003 994 1005
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 994-1005
-
-
Ohta, H.1
-
101
-
-
0036434445
-
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
-
M. Osada Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist Biochem. Biophys. Res. Commun. 299 2002 483 487
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 483-487
-
-
Osada, M.1
-
102
-
-
0036205659
-
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
-
K. Budde First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients J. Am. Soc. Nephrol. 13 2002 1073 1083
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1073-1083
-
-
Budde, K.1
-
103
-
-
15244343497
-
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer
-
A. Boucharaba Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer J. Clin. Invest. 114 2004 1714 1725
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1714-1725
-
-
Boucharaba, A.1
-
104
-
-
7444219945
-
Chronic pain and microglia: The role of ATP
-
K. Inoue Chronic pain and microglia: the role of ATP Novartis Found. Symp. 261 2004 55 64
-
(2004)
Novartis Found. Symp.
, vol.261
, pp. 55-64
-
-
Inoue, K.1
-
105
-
-
13944280988
-
G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
-
J. Radeff-Huang G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival J. Cell. Biochem. 92 2004 949 966
-
(2004)
J. Cell. Biochem.
, vol.92
, pp. 949-966
-
-
Radeff-Huang, J.1
-
106
-
-
2342437623
-
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
-
K. Hama Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1 J. Biol. Chem. 279 2004 17634 17639
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 17634-17639
-
-
Hama, K.1
-
107
-
-
27144452068
-
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells
-
E. Malchinkhuu Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1- phosphate in glioma cells Oncogene 24 2005 6676 6688
-
(2005)
Oncogene
, vol.24
, pp. 6676-6688
-
-
Malchinkhuu, E.1
-
108
-
-
3042523481
-
Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway
-
D. Bian Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway Cancer Res. 64 2004 4209 4217
-
(2004)
Cancer Res.
, vol.64
, pp. 4209-4217
-
-
Bian, D.1
-
109
-
-
15444373513
-
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
-
T. Sanchez PTEN as an effector in the signaling of antimigratory G protein-coupled receptor Proc. Natl. Acad. Sci. U. S. A. 102 2005 4312 4317
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 4312-4317
-
-
Sanchez, T.1
-
110
-
-
12144285600
-
Proteases, extracellular matrix, and cancer: A workshop of the path B study section
-
Y.A. DeClerck Proteases, extracellular matrix, and cancer: a workshop of the path B study section Am. J. Pathol. 164 2004 1131 1139
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1131-1139
-
-
Declerck, Y.A.1
-
111
-
-
15444368022
-
Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells
-
H. Li Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells J. Biol. Chem. 280 2005 10564 10571
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 10564-10571
-
-
Li, H.1
-
112
-
-
0034705477
-
2+ influx in human platelets
-
2+ influx in human platelets J. Biol. Chem. 275 2000 19159 19166
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19159-19166
-
-
Maschberger, P.1
-
113
-
-
0035800886
-
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids
-
K. Hayashi Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids Circ. Res. 89 2001 251 258
-
(2001)
Circ. Res.
, vol.89
, pp. 251-258
-
-
Hayashi, K.1
-
114
-
-
9644260561
-
The role of sphingosine-1-phosphate in smooth muscle contraction
-
K.R. Watterson The role of sphingosine-1-phosphate in smooth muscle contraction Cell. Signal. 17 2005 289 298
-
(2005)
Cell. Signal.
, vol.17
, pp. 289-298
-
-
Watterson, K.R.1
-
115
-
-
0033609118
-
Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid
-
J.A. Weiner, and J. Chun Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid Proc. Natl. Acad. Sci. U. S. A. 96 1999 5233 5238
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 5233-5238
-
-
Weiner, J.A.1
Chun, J.2
-
116
-
-
0038660660
-
Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells
-
Y. Li Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells J. Biol. Chem. 278 2003 9585 9591
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9585-9591
-
-
Li, Y.1
-
117
-
-
0343820101
-
Role of lysophosphatidic acid and rho in glioma cell motility
-
T.J. Manning Jr Role of lysophosphatidic acid and rho in glioma cell motility Cell Motil. Cytoskeleton 45 2000 185 199
-
(2000)
Cell Motil. Cytoskeleton
, vol.45
, pp. 185-199
-
-
Manning Jr., T.J.1
-
118
-
-
0036679066
-
2+-α-actinin and polymerization by rho
-
2+-α-actinin and polymerization by rho Mol. Biol. Cell 13 2002 2692 2705
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2692-2705
-
-
Fukushima, N.1
-
119
-
-
0031008341
-
Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium
-
F.W. Holtsberg Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium J. Neurochem. 69 1997 68 75
-
(1997)
J. Neurochem.
, vol.69
, pp. 68-75
-
-
Holtsberg, F.W.1
-
120
-
-
0035884770
-
Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling
-
J.A. Weiner Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling J. Neurosci. 21 2001 7069 7078
-
(2001)
J. Neurosci.
, vol.21
, pp. 7069-7078
-
-
Weiner, J.A.1
|