Sphingolipid regulation of female gonadal cell apoptosis

Annals of the New York Academy of Sciences

Volumn 905, Issue , 2000, Pages 209-220

  Morita, Yutaka ^a   Tilly, Jonathan L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE 1 PHOSPHATE;

APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELLULAR DISTRIBUTION; CONFERENCE PAPER; FEMALE; GERM CELL; HUMAN; HUMAN CELL; OOCYTE; OVARY CELL; SIGNAL TRANSDUCTION;

FALLOPIA;

EID: 0034102433     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06551.x     Document Type: Conference Paper

References (86)

1. 1. HANNUN, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859.
2. 2. AMUNDSON, S.A., T.G. MYERS & A.J. FORNACE, JR. 1998. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17: 3287-3299.
3. 3. BASU, S. & R. KOLESNICK. 1998. Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 17: 3277-3285.
4. 4. ADAMS, J.M. & S. CORY. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326.
5. 5. CRYNS, V. & J. YUAN. 1998. Proteases to die for. Genes Dev. 12: 1551-1570.
6. 6. GREEN, D.R. 1998. Apoptotic pathways: the roads to ruin. Cell 94: 695-698.
7. 7. GREEN, D.R. & J.C. REED. 1998. Mitochondria and apoptosis. Science 281: 1309-1312.
8. 8. KORSMEYER, S.J. 1998. BCL-2 family and the regulation of programmed cell death. Cancer Res. 59(suppl.): 1693s-1700s.
9. 9. REED, J.C. 1998. Bcl-2 family proteins. Oncogene 17: 3225-3236.
10. 10. THORNBERRY, N.A. & Y. LAZEBNIK. 1998. Caspases: enemies within. Science 281: 1312-1316.
11. 11. KOLESNICK, R.N. & M. KRONKE. 1998. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60: 643-665.
12. 12. SHAUL, P.W. & R.G. ANDERSON. 1998. Role of plasmalemmal caveolae in signal transduction. Am. J. Physiol. 275: 843-845.
13. 13. LIU, B., L.M. OBEID & Y.A. HANNUN. 1997. Sphingomyelinases in cell regulation. Semin. Cell Dev. Biol. 8: 311-322.
14. 14. LAVADE, T. & J.P. JAFFREZOU. 1999. Signalling sphingomyelinases: which, where, how, and why? Biochim. Biophys. Acta 1438: 1-17.
15. 15. BOSE, R., M. VERHEIJ, A. HAIMOVITZ-FREIDMAN, K. SCOTTO, Z. FUKS & R.N. KOLESNICK. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82: 405-414.
16. 16. MERRILL, A.H., JR., E.M. SCHMELZ, D.L. DILLEHAY, S. SPIEGEL, J.A. SHAYMAN, J.J. SCHROEDER, R.T. RILEY, K.A. VOSS & E. WANG. 1997. Sphingolipids - the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142: 208-225.
17. 17. KOLESNICK, R. & Y.A. HANNUN. 1999. Ceramide and apoptosis. Trends Biochem. Sci. 24: 224-225.
18. 18. SPIEGEL, S., O. CUVILLIER, L.C. EDSALL, T. KOHAMA, R. MENZELEEV, Z. OLAH, A. OLIVERA, G. PIRIANOV, D.M. THOMAS, Z. TU, J.R. VAN BROOKLYN & F. WANG. 1998. Sphingosine-1-phosphate in cell growth and cell death. Ann. N.Y. Acad. Sci. 845: 11-18.
19. 19. SPIEGEL, S. 1999. Sphingosine 1-phosphate: a prototype of a new class of second messengers. J. Leukocyte Biol. 65: 341-344.
20. 20. CUVILLIER, O., G. PIRIANOV, B. KLEUSER, P.G. VANEK, O.A. COSO, S. GUTKIND & S. SPIEGEL. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381: 800-803.
21. 21. HIRSHFIELD, A.N. 1991. Development of follicles in the mammalian ovary. Int. Rev. Cytol. 124: 43-101.
22. 22. GUMIENNY, T.L., E. LAMBIE, E. HARTWEIG, H.R. HORVTTZ & M.O. HENGARTNER. 1999. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germ line. Development 126: 1011-1022.
23. 23. MORITA, Y. & J.L. TILLY. 1999. Oocyte apoptosis: like sand through an hourglass. Dev. Biol. 213: 1-17.
24. 24. TILLY, J.L. & R. ROBLES. 1999. Apoptosis and its impact in clinical reproductive medicine. In Molecular Biology in Reproductive Medicine, pp. 79-101. Parthenon Pub. New York.
25. 25. COUCOUVANIS, E.C., S.W. SHERWOOD, C. CARSWELL-CRUMPTON, E.G. SPACK & P.P. JONES. 1993. Evidence that the mechanism of prenatal germ cell death in the mouse is apoptosis. Exp. Cell Res. 209: 238-247.
26. 26. RATTS, V.S., J.A. FLAWS, R. KOLP, C.M. SORENSON & J.L. TILLY. 1995. Ablation of bcl-2 gene expression decreases the number of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology 136: 3665-3668.
27. 27. DE POL, A., F. VACCINA, A. FORABOSCO, E. CAVAZZUTI & L. MARZONA. 1997. Apoptosis of germ cells during human prenatal oogenesis. Hum. Reprod. 12: 2235-2241.
28. 28. MORITA, Y., T.M. MANGANARO, X-J. TAO, S. MARTIMBEAU, P.K. DONAHOE & J.L. TILLY. 1999. Requirement for phosphatidylinositol-3′-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse. Endocrinology 140: 941-949.
29. 29. MORITA, Y. & J.L. TILLY. 1999. Segregation of retinoic acid effects on fetal ovarian germ cell mitosis versus apoptosis by requirement for new macromolecular synthesis. Endocrinology 140: 2696-2703.
30. 30. TILLY, J.L. & V.S. RATTS. 1996. Biological and clinical importance of ovarian cell death. Contemp. Obstet. Gynecol. 41: 59-86.
31. 31. BAKER, T.G. 1963. A quantitative and cytological study of germ cells in human ovaries. Proc. R. Soc. Lond. B158: 417-433.
32. 32. GOUGEON, A. 1996. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr. Rev. 17: 121-155.
33. 33. PEREZ, G.I., R. ROBLES, C.M. KNUDSON, J.A. FLAWS, S.J. KORSMEYER & J.L. TILLY. 1999. Prolongation of ovarian life span into advanced chronological age by Bax-deficiency. Nat. Genet. 21: 200-203.
34. 34. MORITA, Y., G.I. PEREZ, D.V. MARAVEI, K.I. TILLY & J.L. TILLY. 1999. Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro. Mol. Endocrinol. 13: 841-850.
35. 35. CHUN, S-Y, H. BILLIG, J.L. TILLY, I. FURUTA, A. TSAFRIRI & A.J.W. HSUEH. 1994. Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Endocrinology 135: 1845-1853.
36. long messenger ribonucleic acid levels. Endocrinology 136: 232-241.
37. 37. TILLY, J.L. & K.I. TILLY. 1995. Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology 136: 242-252.
38. 38. TILLY, J.L. 1996. Apoptosis and ovarian function. Rev. Reprod. 1: 162-172.
39. 39. YOSHIMURA, Y., S.A. TISCHKAU & J.M. BAHR. 1994. Destruction of the germinal disc region of an immature preovulatory follicle suppresses follicular maturation and ovulation. Biol. Reprod. 51: 229-233.
40. 40. YAO, H.H., K.K. VOLENTINE & J.M. BAHR. 1998. Destruction of the germinal disc region of an immature preovulatory chicken follicle induces atresia and apoptosis. Biol. Reprod. 59:516-521.
41. 41. FEREZ, G.I., C.M. KNUDSON, L. LEYKIN, S.J. KORSMEYER & J.L. TILLY. 1997. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat. Med. 3: 1228-1232.
42. 42. TILLY, J.L. 1998. Cell death and species propagation: molecular and genetic aspects of apoptosis in the vertebrate female gonad. In When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death, pp. 431-452. Wiley-Liss. New York.
43. 43. SPEED, R.M. 1988. The possible role of meiotic pairing anomalies in the atresia of human fetal oocytes. Hum. Genet. 78: 260-266.
44. 44. MITTWOCH, U. & S.K. MAHADEVAIAH. 1992. Unpaired chromosomes at meiosis: cause or effect of gametogenic insufficiency? Cytogenet. Cell Genet. 59: 274-279.
45. 45. CONLON, I. & M. RAFF. 1999. Size control in animal development. Cell 96: 235-244.
46. 46. MINTZ, B. & E.S. RUSSELL. 1957. Gene-induced embryological modification of primordial germ cells in the mouse. J. Exp. Zool. 134: 207-230.
47. 47. KENNEDY, S.G., A.J. WAGNER, S.D. CONZEN, J. JORDAN, A. BELLACOSA, P.N. TSICHLIS & N. HAY. 1997. The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11: 701-713.
48. 48. O'CONNOR, R. 1998. Survival factors and apoptosis. Adv. Biochem. Eng. Biotechnol. 62: 137-166.
49. 49. ZHOU, H., S.A. SUMMERS, M.J. BIRNBAUM & R.N. PITTMAN. 1998. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem. 273: 16568-16575.
50. 50. ZUNDEL, W. & A. GIACCIA. 1998. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev. 12: 1941-1946.
51. 51. SUMMERS, S.A., L.A. GARZA, H. ZHOU & M.J. BIRNBAUM. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18: 5457-5464.
52. 52. BERGERON, L., G.I. PEREZ, G. MACDONALD, L. SHI, Y. SUN, A. JURISICOVA, S. VARMUZA, K.E. LATHAM, J.A. SALTER, H. HARA, M.A. MOSKOWITZ, E. LI, A. GREENBERG, J.L. TILLY & J. YUAN. 1998. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12: 1304-1314.
53. 53. JURISICOVA, A., K.E. LATHAM, R.F. CASPER & S.L. VARMUZA. 1998. Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol. Reprod. Dev. 51: 243-253.
54. 54. GOETZL, E.J. & S. AN. 1998. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12: 1589-1598.
55. 55. GHAFOURIFAR, P., S.D. KLEIN, O. SCHUCHT, U. SCHENK, M. PRUSCHY, S. ROCHA & C. RICHTER. 1999. Ceramide induces cytochrome c release from isolated mitochondria: importance of mitochondrial redox state. J. Biol. Chem. 274: 6080-6084.
56. 56. LI, H. & J. YUAN. 1999. Deciphering the pathways of life and death. Curr. Opin. Cell Biol. 11: 261-266.
57. 57. ZOU, H., Y. LI, X. LIU & X. WANG. 1999. An APAF-1, cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274: 11549-11556.
58. 58. SANTANA, P., L. LLANES, I. HERNANDEZ, G. GALLARDO, J. QUINTANA, J. GONZALEZ, F. ESTEVEZ, C. RUIZ DE GALARRETA & L.F. FANJUL. 1995. Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells. Endocrinology 136: 2345-2348.
59. 59. SANTANA, P., L. LLANES, I. HERNANDEZ, I. GONZALEZ-ROVAYNA, C. TABRAUE, J. GONZALEZ-REYES, J. QUINTANA, F. ESTEVEZ. C.M. RUIZ DE GALARRETA & L.F. FANJUL. 1996. Interleukin-1β stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Endocrinology 137: 2480-2489.
60. 60. FOGHI, A., A. RAVANDI, K.J. TEERDS, H. VAN DER DONK, A. KUKSIS & J. DORRINGTON. 1998. Fas-induced apoptosis in rat theca/interstitial cell signals through sphingomyelin-ceramide pathway. Endocrinology 139: 2041-2047.
61. 61. TOKUMURA, A., M. MIYAKE, Y. NlSHIOKA, S. YAMANO, T. AONO & K. FUKUZAWA. 1999. Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of in vitro fertilization patients. Biol. Reprod. 61: 195-199.
62. 62. BUDNIK, L.T. & A.K. MUKHOPADNYAY. 1997. Functional lysophosphatidic acid receptor in bovine luteal cells. FEBS Lett. 419: 4-8.
63. 63. KOBAYASHI, T., S. YAMANO, S. MURAYAMA, H. ISHIKAWA, A. TOKUMURA & T. AONO. 1994. Effect of lysophosphatidic acid on the preimplantation development of mouse embryos. FEBS Lett. 351: 38-40.
64. 64. WITTY, J.P., J.T. BRIDGHAM & A.L. JOHNSON. 1996. Induction of apoptotic cell death in hen granulosa cells by ceramide. Endocrinology 137: 5269-5277.
65. 65. SANTANA, P., L.A. PENA, A. HAIMOVITZ-FREIDMAN, S. MARTIN, D. GREEN, M. MCLOUCHLIN, C. CORDON-CARDO, E.H. SCHUCHMAN, Z. FUKS & R.N. KOLESNICK. 1996. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86: 189-199.
66. 66. HUANG, C., W.Y. MA, M. DING, G.T. BOWDEN & Z. DONG. 1997. Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 272: 27753-27757.
67. 67. TILLY, K.I., G.I. PEREZ & J.L. TILLY. 1996. Ceramide-induced apoptosis in ovarian follicles: kinetic analysis and modulation by potassium chloride efflux (abstract). Mol. Biol. Cell 7: 194.
68. 68. KAIPIA, A., S-Y. CHUN, K. EISENHAUER & A.J.W. HSUEH. 1996. Tumor necrosis factor-a and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology 137: 4864-4870.
69. 69. TILLY, K.I., G.I. PEREZ, X-J. TAO, L.M. OBEID & J.L. TILLY. 1997. Evidence of a role for ceramide and the stress-activated protein kinases, JNK and p38, in ovarian follicular atresia (abstract). In Proceedings from the 79th Annual Meeting of the Endocrine Society.
70. 70. MARTIMBEAU, S. & J.L. TILLY. 1997. Physiological cell death in endocrine-dependent tissues: an ovarian perspective. Clin. Endocrinol. 46: 241-254.
71. 71. RUBLES, R., X-J. TAO, A.M. TRBOVICH, D.V. MARAVEI, R. NAHUM, G.I. PEREZ, K.I. TILLY & J.L. TILLY. 1999. Localization, regulation, and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary. Endocrinology 140: 2641-2644.
72. 72. FLAWS, J.A., K. KUGU, A.M. TRBOVICH, A. DESANTI, K.I. TILLY, A.N. HIRSHFIELD & J.L. TILLY. 1995. Interleukin-1β-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Endocrinology 136: 5042-5053.
73. 73. BOONE, D.L. & B.K. TSANG. 1998. Caspase-3 in the rat ovary: localization and possible role in follicular atresia and luteal regression. Biol. Reprod. 58: 1533-1539.
74. 74. KUGU, K., V.S. RATTS, G.N. PIQUETTE, K.I. TILLY, X-J. TAO, S. MARTIMBEAU, G.W. ABERDEEN, S. KRAJEWSKI, J.C. REED, G.J. PEPE, E.D. ALBRECHT & J.L. TILLY. 1998. Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary. Cell Death Differ. 5: 67-76.
75. 75. MARAVEI, D.V., A.M. TRBOVICH, G.I. PEREZ, K.I. TILLY, D. BANACH, R.V. TALANIAN, W.W. WONG & J.L. TILLY. 1997. Cleavage cytoskeletal proteins by caspases during ovarian cell death: evidence that cell-free systems do not always mimic apoptotic events in intact cells. Cell Death Differ. 4: 707-712.
76. 76. WAXMAN, J. 1983. Chemotherapy and the adult gonad: a review. J. R. Soc. Med. 76: 144-148.
77. 77. FAMILIARI, G., A. CAGGIATI, S.A. NOTTOLA, M. ERMINI, M.R. DI BENEDETTO & P.M. MOTTA. 1993. Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin's disease. Hum. Reprod. 8: 2080-2087.
78. 78. REICHMAN, B.S. & K.B. GREEN. 1994. Breast cancer in young women: effect of chemotherapy on ovarian function, fertility, and birth defects. J. Natl. Cancer Inst. Monogr. 16: 125-129.
79. 79. RIED, H.L. & N. JAFFE. 1994. Radiation-induced changes in long-term survivors of childhood cancer after treatment with radiation therapy. Semin. Roentgenol. 29: 6-14.
80. 80. TAKIZAWA, K., I. YOKOO, Y. SHIMA, Y. INOU, M. SATO, T. IGUCHI & Y. TAKEDA. 1989. Quantitative evaluation for murine oocyte toxicity following intraperitoneal treatment with chemotherapeutic agents. Acta Obstet. Gynaecol. Jpn. 41: 715-722.
81. 81. SHIMA, Y. 1994. Quantitative study on the effect of oncostatic toxicity on murine fertility. Acta Obstet. Gynaecol. Jpn. 46: 589-596.
82. 82. HORINOUCHI, K., S. ERLICH, D.P. PERL, K. FERLINZ, C.L. BISGAIER, K. SANDHOFF, R.J. DESNICK, C.L. STEWART & E.H. SCHUCHMAN. 1995. Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nat. Genet. 10: 288-293.
83. 83. JAFFREZOU, J.P., T. LEVADE, A. BETTAIEB, N. ANDRIEU, C. BEZOMBES, N. MAESTRE, S. VERMEERSCH, A. ROUSSE & G. LAURENT. 1996. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J. 15: 2417-2424.
84. 84. BROWN, J.M. & B.C. WOUTERS. 1999. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59: 1391-1399.
85. 85. TILLY, J.L. & A.L. JOHNSON. 1999. Chemotherapy and apoptosis in the ovary: cancer treatment comes with a price. In Apoptosis and Cancer Chemotherapy, pp. 257-273. Humana Press. Totowa, New Jersey.
86. 86. REYNOLDS, T. 1999. Cell death genes may hold clues to preserving fertility after chemotherapy. J. Natl. Cancer Inst. 91: 664-666.