Differential modulation by estradiol of p-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells

Anticancer Research

Volumn 22, Issue 4, 2002, Pages 2253-2259

  Zampieri, Luigi ^a   Bianchi, Pepita ^a   Ruff, Paul ^a   Arbuthnot, Patrick ^a  

^a UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

AP1; Breast cancer; Doxorubicin; Estradiol; Flow cytometry; Multidrug resistance; P glycoprotein; Sp1

Indexed keywords

DOXORUBICIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; CORRELATION ANALYSIS; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 0036331937     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: Relationship to MDR1, MnSOD, and TNF gene expression
2. Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: Correlation with clinico-pathological features
3. Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance
4. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
5. The biology of breast tumor progression. Acquisition of hormone independence and resistance to cytotoxic drugs
6. Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp 170 expression and its possible functional significance
7. Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression
8. Effect of tamoxifen on the multidrug-resistant phenotype in human breast cancer cells: Isobologram, drug accumulation, and M(r) 170,000 glycoprotein (gp170) binding studies
9. Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues
10. Prognostic significance of oestrogen receptor beta in breast cancer
11. The estrogen receptor family
12. Identification of estrogen-receptor beta2, a functional variant of estrogen-receptor beta expressed in normal rat tissues
13. Differential ligand activation of estrogen-receptors ERalpha and ERbeta at AP1 sites
14. Ligand-, cell-, and estrogen-receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements
15. Regulation of multidrug resistance through the cAMP and EGF signalling pathways
16. Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome
17. Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells
18. Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence
19. Multi-platform, multi-site instrumentation and reagent standardization
20. Quantitative fluorescence flow cytometry: A comparison of the three techniques for direct and indirect immunofluorescence
21. Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin
22. The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2
23. Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells
24. Selective loss of estrogen receptor beta in malignant human colon
25. Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer
26. Cross-talk between peptide growth factor and estrogen receptor signaling pathways
27. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
28. P-glycoprotein expression in the Golgi apparatus of multidrug-resistant cells
29. Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells
30. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer
31. Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer
32. Coexpression of estrogen receptor alpha and beta: Poor prognostic factors in human breast cancer?
33. SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity
34. The human multidrug resistance gene: Sequences upstream and downstream of the initiation site influence transcription
35. Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr 1 gene in vivo
36. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
37. DNA looping and Sp1 multimer links: A mechanism for transcriptional synergism and enhancement
38. DNA looping between sites for transcriptional activation: Self-association of DNA-bound Sp1