Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells

Diabetologia

Volumn 47, Issue 6, 2004, Pages 998-1008

  Movahedi, B ^a   Van De Casteele, M ^a   Caluwe N ^a   Stange G ^a   Breckpot, K ^b   Thielemans, K ^b   Vreugdenhil, G ^c   Mathieu, C ^d   Pipeleers, D ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Apoptosis; Diabetes mellitus; Insulin; Islets of Langerhans; Pancreas

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN OXIDE; PROTEIN PRECURSOR; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL DAMAGE; CELL INTERACTION; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DENDRITIC CELL; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; PANCREAS CELL; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STRESS;

EID: 3142699932     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1426-3     Document Type: Article

References (48)

1. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633
2. Pipeleers D, Ling Z (1992) Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 8:209-227
3. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PG, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313:353-360
4. Mon Y, Suko M, Okudaira H et al. (1986) Preventive effects of cyclosporine on diabetes in NOD mice. Diabetologia 29:244-247
5. Held W, MacDonald HR, Weissman IL, Hess MW, Mueller C (1990) Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes. Proc Natl Acad Sci USA 87:2239-2243
6. Rabinovitch A (1994) Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43:613-621
7. Welsh M, Welsh N, Bendtzen K et al. (1995) Comparison of mRNA contents of interleukin-1 beta and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38:153-160
8. Pilstrom B, Bjork L, Bohme J (1997) Monokine-producing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase. J Autoimmun 10:147-155
9. Mandrup-Poulsen T (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005-1029
10. McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett JA (1996) Cytokines and nitric oxide in islet inflammation and diabetes. Proc Soc Exp Biol Med 211:24-32
11. Yang XD, Tisch R, Singer SM et al. (1994) Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 180:995-1004
12. Kagi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, Mak TW (1999) TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J Immunol 162:4598-4605
13. Green EA, Eynon EE, Flavell RA (1998) Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 9:733-743
14. Green EA, Flavell RA (1999) Tumor necrosis factor-alpha and the progression of diabetes in non- obese diabetic mice. Immunol Rev 169:11-22
15. Green EA, Flavell RA (2000) The temporal importance of TNFalpha expression in the development of diabetes. Immunity 12:459-469
16. Christen U, Wolfe T, Mohrle U et al. (2001) A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis. J Immunol 166:7023-7032
17. Pavlovic D, Winkel M van de, Auwera B van der et al. (1997) Effect of interferon-gamma and glucose on major histocompatibility complex class I and class II expression by pancreatic beta- and non-beta-cells. J Clin Endocrinol Metab 82:2329-2336
18. Pavlovic D, Chen MC, Bouwens L, Eizirik DL, Pipeleers D (1999) Contribution of ductal cells to cytokine responses by human pancreatic islets. Diabetes 48:29-33
19. Pipeleers D, Hoorens A, Marichal-Pipeleers M, Van de Casteele M, Bouwens L, Ling Z (2001) Role of pancreatic beta-cells in the process of beta-cell death. Diabetes 50 [Suppl 1]:S52-S57
20. Bouwens L, Pipeleers DG (1998) Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia 41:629-633
21. Ling Z, Pipeleers DG (1996) Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 98:2805-2812
22. Keymeulen B, Ling Z, Gorus FK et al. (1998) Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41:452-459
23. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138
24. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C (2003) The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 14:33-43
25. Pipeleers DG, in't Veld PA, Van de Winkel M, Maes E, Schuit FC, Gepts W (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117:806-816
26. Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D (1996) Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574
27. Pipeleers D, Van de Winkel M (1986) Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci USA 83:5267-5271
28. Romani N, Reider D, Heuer M et al. (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 196:137-151
29. Tuyaerts S, Noppe SM, Corthals J et al. (2002) Generation of large numbers of dendritic cells in a closed system using Cell Factories. J Immunol Methods 264:135-151
30. Jonuleit H, Kuhn U, Muller G et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27:3135-3142
31. Breckpot K, Dullaers M, Bonehill A et al. (2003) Lentivirally transduced dendritic cells as a tool for cancer immunotherapy. J Gene Med 5:654-667
32. Dinter A, Berger EG (1998) Golgi-disturbing agents. Histochem Cell Biol 109:571-590
33. Shurety W, Merino-Trigo A, Brown D, Hume DA, Stow JL (2000) Localization and post-Golgi trafficking of tumor necrosis factor-alpha in macrophages. J Interferon Cytokine Res 20:427-438
34. Cuenda A, Rouse J, Doza YN et al. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233
35. Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML (1998) Evidence for involvement of the proteasome complex (26S) and NfkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 47:583-591
36. Bennett BL, Sasaki DT, Murray BW et al. (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98:13681-13686
37. Heitmeier MR, Arnush M, Scarim AL, Corbett JA (2001) Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes. J Biol Chem 276:11151-11158
38. Raingeaud J, Gupta S, Rogers JS et al. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen- activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270:7420-7426
39. Hoorens A, Pipeleers D (1999) Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 42:55-59
40. Mandrup-Poulsen T, Helqvist S, Wogensen LD et al. (1990) Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol 164:169-193
41. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL (1997) Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138:2610-2614
42. Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J (1987) Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol 139:4077-4082
43. Yamaguchi Y, Tsumura H, Miwa M, Inaba K (1997) Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow. Stem Cells 15:144-153
44. Rieser C, Bock G, Klocker H, Bartsch G, Thurnher M (1997) Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J Exp Med 186:1603-1608
45. Zhou LJ, Tedder TF (1996) CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA 93:2588-2592
46. Pukel C, Baquerizo H, Rabinovitch A (1988) Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 37:133-136
47. Grewal IS, Grewal KD, Wong FS, Picarella DE, Janeway CA Jr, Flavell RA (1996) Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J Exp Med 184:1963-1974
48. Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG (2000) Interleukin-1 beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis. Diabetes 49:340-345