Effect of interferon-γ/and glucose on major histocompatibility complex class I and class II expression by pancreatic β- and non-β-cells

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 7, 1997, Pages 2329-2336

  Pavlovic, Dejan ^a   Van De Winkel, Marnix ^a   Van Der Auwera, Bart ^a   Chen, Meng Chi ^a   Schuit, Frans ^a   Bouwens, Luc ^a   Pipeleers, Daniel ^a,b  

^a DIABETES RESEARCH CENTER   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 19 FRAGMENT; GAMMA INTERFERON; GLUCOSE;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PANCREAS CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; ANIMALS; BETA 2-MICROGLOBULIN; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUCOSE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; ISLETS OF LANGERHANS; KERATINS; MALE; MIDDLE AGED; PANCREAS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0030762472     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.7.2329     Document Type: Article

References (37)

1. Huber C, Irschick E. 1988 Cytokines in the regulation of allograft rejection. Bibl Cardiol. 43:103-110.
2. Percopo CM, Hooks JJ, Shinohara T, Caspi R, Detrick B. 1990 Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation. J Immunol. 145:4101-4107.
3. Niederwieser D, Aubock J, Troppmair J, et al. 1988 IFN-mediated induction of MHC antigen expression on human keratinocytes and its influence on in vitro alloimmune responses. J Immunol. 140:2556-2564.
4. Markmann JF, Tomaszewski J, Posselt AM, et al. 1990 The effect of islet cell culture in vitro at 24°C on graft survival and MHC antigen expression. Transplantation. 49:272-277.
5. Cearns-Spielman J, Cavender DE, Wood PJ. 1990 Interferon-gamma increases susceptibility of murine pancreatic beta cells to lysis by allogeneic cytotoxic T lymphocytes. Autoimmunity. 8:135-142.
6. Botazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble R. 1985 In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med. 313:353-360.
7. Foulis AK, Farquharson MA, Hardman R. 1987 Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin dependent) diabetes mellitus. Diabetologia. 30:333-343.
8. Somoza N, Vargas F, Roura-Mir C, et al. 1994 Pancreas in recent onset insulin-dependent diabetes mellitus. J Immunol. 153:1360-1377.
9. Itoh N, Hanafusa T, Miyazaki A, et al. 1993 Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest. 92:2313-2322.
10. Foulis AK, McGill M, Farquaharson MA. 1991 Insulitis in type 1 (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes, and interferon-γ containing cells. J Pathol. 165:97-103.
11. Dean BM, Walker R, Bone AJ, Baird JD, Cooke A. 1985 Pre-diabetes in the spontaneously diabetic BB / E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells. Diabetologia. 28:464-466.
12. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF. 1995 IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol. 154:4874-4882.
13. Zipris D, Greiner DL, Malkani S, Whalen B, Mordes JP, Rossini AA. 1996 Cytokine gene expression in islets and thyroids of BB rats: IFN-γ and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats. J Immunol. 156:1315-1321.
14. Pujol-Borrell R, Todd I, Doshi M, et al. 1987 HLA class II induction in human islet cells by interferon-γ plus tumor necrosis factor or lymphotoxin. Nature. 326:304-306.
15. Campbell IL, Bizilj K, Colman PG, Tuch BE, Harrison LC. 1985 Interferon-γ induces the expression of HLA-A,B,C but not HLA-DR on human pancreatic β-cells. J Clin Endocrinol Metab. 62:1101-1109.
16. Campbell IL, Wong GHW, Schrader JW, Harrison LC. 1985 Interferon-γ enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells. Diabetes. 34:1205-1209.
17. Leiter EH, Christianson GJ, Serreze DV, Ting AT, Worthen SM. 1989 MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice. J Exp Med. 170:1243-1262.
18. Wogensen L, Molony L, Gu D, Krahl T, Zhu S, Sarvetnick N. 1994 Postnatal anti-interferon-γ treatment prevents pancreatic inflammation in transgenic mice with β-cell expression of interferon-γ. J Interferon Res. 14:111-116.
19. Kay TWH, Campbell IL, Oxbrow L, Harrison LC. 1991 Overexpression of class I major histocompatibility complex accompanies insulitis in the nonobese diabetic mouse and is prevented by anti-interferon-γ antibody. Diabetologia. 34:779-785.
20. r islet cell autoantigen expression. Diabetes. 38:1326-1328.
21. 65 in human pancreatic islets. J Clin Endocrinol Metab. 75:1574-1576.
22. Pipeleers DG, In't Veld PA, Van De Winkel M, Maes. E, Schuit F, Gepts W. 1985 A new in vitro model for the study of pancreatic A and B cells. Endocrinology. 117:806-816.
23. Bouwens L, Braet F, Heimberg H. 1995 Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture. J Histochem Cytochem. 43:245-253.
24. Eizirik DL, Korbutt GS, Hellerström C. 1992 Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest. 90:1263-1268.
25. Ling Z, Pipeleers D. 1996 Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest. 98:2805-2812.
26. Bouwens L, Lu WG, De Krijger R. 1997 Proliferation in the human fetal endocrine pancreas. Diabetologia. 40:398-404.
27. Schüsler MH, Skoudy A, Ramaekers F, Real FX. 1992 Intermediate filaments as differentiation markers of normal pancreas and pancreas cancer. Am J Pathol. 140:559-568.
28. Bouwens L, Wang R, De Blay E, Pipeleers DG, Klöppel G. 1994 Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes. 43:1279-1283.
29. Wang AM, Doyle MV, Mark DF. 1989 Quantitation of mRNA by polymerase chain reaction. Proc Natl Acad Sci USA. 86:9717-9721.
30. Ibrahim L, Dominiquez M, Yacoub M. 1993 Primary human adult lung epithelial cells in vitro: response to interferon-gamma and cytomegalovirus. Immunology. 79:119-124.
31. Wang YC, Herskowitz A, Gu LB, et al. 1991 Influence of cytokines and immunosuppressive drugs on major histocompatibility complex class I/II expression by human cardiac myocytes in vitro. Hum Immunol. 31:123-133.
32. Satoh J, Paty DW, Kim SU. 1995 Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular adhesion molecule-1 in cultured fetal human astrocytes. Neurology. 45:367-373.
33. Sarvetnick N, Shizuru J, Liggitt D, et al. 1990 Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature. 346:844-847.
34. Pipeleers DG, Marichal M, Malaisse WJ. 1973 The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity. Endocrinology. 93:1001-1011.
35. Pipeleers D. 1992 Heterogeneity in pancreatic β-cells population. Diabetes. 41:777-781.
36. In't Veld P, Pipeleers DG. 1988 In situ analysis of pancreatic islets in rats developing diabetes: appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity. J Clin Invest. 82:1123-1128.
37. Pujol-Borrell R, Todd I, Doshi M, Gray D, Feldmann M, Botazzo GF. 1986 Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol. 65:128-139.