Role of pancreatic β-cells in the process of β-cell death

Diabetes

Volumn 50, Issue SUPPL. 1, 2001, Pages

  Pipeleers, Daniel ^a   Hoorens, Anne ^a   Marichal Pipeleers, Miriam ^a   Van De Casteele, Mark ^a   Bouwens, Luc ^a   Ling, Zhidong ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; NITRIC OXIDE; RADICAL;

ANIMAL CELL; APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CYTOTOXICITY; HUMAN; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; RAT;

EID: 0035129049     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2007.s52     Document Type: Conference Paper

References (43)

1. Pathologic anatomy of the pancreas in juvenile diabetes mellitus
2. Autoimmunity in juvenile diabetics and their families
3. Pancreatic beta cells in insulin-dependent diabetes
4. Prevalence of residual beta-cell function in insulin-dependent diabetics in relation to age at onset and duration of diabetes
5. Action of toxic drugs on islet cells
6. The role of interleukin-1 in the pathogenesis of IDDM
7. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
8. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis
9. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis
10. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
11. Pancreatic B cells possess defense mechanisms against cell-specific toxicity
12. Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
13. Death of the pancreatic B-cell
14. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
15. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
16. Antioxidant therapy for the prevention of type I diabetes
17. Determinants of the selective toxicity of alloxan to the pancreatic B cell
18. Pancreatic islet glucose metabolism and regulation of insulin secretion
19. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans: Evidence for the beta-cell as a source and site of action of nitric oxide
20. Interaction of interleukin-1 with islet beta-cells: Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression
21. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
22. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
23. Contribution of ductal cells to cytokine responses by human pancreatic islets
24. IL-1 produced and released endogenously within human islets inhibits beta cell function
25. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
26. Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
27. Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas
28. Heterogeneity in pancreatic beta-cell population
29. Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis
30. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
31. Nicotinamide: Potential for the prevention of type 1 diabetes?
32. Reversal of streptozotocin diabetes with nicotinamide
33. Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis: An observation in nonobese diabetic (NOD) mice
34. Nicotinamide in type 1 diabetes: Mechanism of action revisited
35. A new in vitro model for the study of pancreatic A and B cells
36. Extra-insular beta-cells associated with ductules are frequent in adult human pancreas
37. New perspectives on the microvasculature of the islets of Langerhans in the rat
38. Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
39. A role for macrophages in the pathogenesis of type 1 diabetes
40. A regulatory defect of constitutive NO-synthase in islet endothelial cells correlates with probability of disease manifestation in BBdp rats
41. Implantation of standardized β-cell grafts in a liver segment of insulin-dependent diabetic patients: Graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
42. Effect of interferon-gamma and glucose on major histocompatibility complex class I and class II expression by pancreatic beta- and non-beta-cells