Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, IKr, and the underlying hERG ion channel

Basic Research in Cardiology

Volumn 99, Issue 4, 2004, Pages 279-287

  Thomas, Dierk ^a   Kiehn, Johann ^a   Katus, Hugo A ^a   Karle, Christoph A ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Adrenergic (ant)agonists; Arrhythmia; HERG; K channel; Long QT syndrome

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; HEART RECEPTOR; ISOPRENALINE; NIFEDIPINE; NISOLDIPINE; POTASSIUM CHANNEL HERG;

ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; EMOTIONAL STRESS; EXERCISE; GENOTYPE; HEART ARRHYTHMIA; HEART RHYTHM; ISCHEMIC HEART DISEASE; LONG QT SYNDROME; NONHUMAN; PATHOPHYSIOLOGY; PHYSICAL STRESS; POTASSIUM CURRENT; REGULATORY MECHANISM; REVIEW;

EID: 3142687701     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-004-0474-7     Document Type: Review

References (86)

1. Kr potassium channels and is associated with cardiac arrhythmia. Cell 97: 175-187
2. + channel gating by activation of a G protein-coupled receptor and protein kinase C. J Physiol 511: 333-346
3. Bender JS (1996) Supraventricular tachyarrhythmias in the surgical intensive care unit: an under-recognized event. Am Surg 62: 73-75
4. + channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. Circ Res 89: 1168-1176
5. Breithardt OA, Flachskampf FA, Klues HG (1998) Life threatening acute complications of dobutamine-atropine stress echocardiography: a case report. Z Kardiol 87: 492-498
6. Brodde OE, Michel MC (1999) Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 51: 651-689
7. Busch AE, Eigenberger B, Jurkiewicz NK, Salata JJ, Pica A, Suessbrich H, Lang F (1998) Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. Br J Pharmacol 123: 23-30
8. Carmeliet E (1993) Mechanisms and control of repolarization. Eur Heart J 14 (Suppl H): 3-13
9. Cui J, Kagan A, Qin D, Mathew J, Melman YF, McDonald TV (2001) Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J Biol Chem 276: 17244-17251
10. + channel by dual pathways. Curr Biol 10: 671-674
11. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803
12. Dabrowska B, Pruszczyk P, Dabrowski A, Feltynowski T, Wocial B, Januszewicz W (1995) Influence of alpha-adrenergic blockade on ventricular arrhythmias, QTc interval and heart rate variability in pheochromocytoma. J Hum Hypertens 9: 925-929
13. Ficker E, Thomas D, Viswanathan PC, Dennis AT, Priori SG, Napolitano C, Memmi M, Wible BA, Kaufman ES, Ivengar S, Schwartz PJ, Rudy Y, Brown AM (2000) Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome. Am J Physiol 279: H1748-H1756
14. Gusovsky F, Gutkind JS (1991) Selective effects of activation of protein kinase C isoenzymes on cyclic AMP accumulation. Mol Pharmacol 39:124-129
15. Kr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J Physiol 522: 391-402
16. Hjalmarson A (1997) Effects of beta blockade on sudden cardiac death during acute myocardial infarction and the postinfarction period. Am J Cardiol 80: 35J-39J
17. Hjalmarson A (1999) Prevention of sudden cardiac death with beta blockers. Clin Cardiol 22: V11-V15
18. Hsu C, Yang SL, Hsu SP, Hsu HK, Liu MS (1997) Differential activation of protein kinase A in various regions of myocardium during sepsis. J Surg Res 71: 161-165
19. Iost N, Virag L, Opincariu, M, Szecsi J, Varro A, Papp JG (1998) Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 40: 508-515
20. Janse MJ, Wit AL (1989) Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev 69: 1049-1169
21. Jiang M, Dun W, Fan JS, Tseng GN (1999) Use-dependent 'agonist' effect of azimilide on the HERG channel. J Pharmacol Exp Ther 291: 1324-1336
22. + channel activity. EMBO J 21: 1889-1898
23. Kamarck T, Jennings JR (1991) Biobehavioral factors in sudden cardiac death. Psychol Bull 109: 42-75
24. Kang JX, Leaf A (1995) Prevention and termination of beta-adrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes. Biochem Biophys Res Commun 208: 629-636
25. + current is inhibited by beta 1-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways. Cardiovasc Res 53: 355-362
26. 3-adrenoceptors to the KvLQT1/MinK potassium channel. J Biol Chem 275: 26743-26747
27. 4-adrenoceptor pharmacology. Naunyn-Schmiedeberg's Arch Pharmacol 363: 87-93
28. Kaumann AJ, Molenaar P (1997) Modulation of human cardiac function through 4 β-adrenoceptor populations. Naunyn-Schmiedeberg's Arch Pharmacol 355: 667-681
29. Keating MT, Sanguinetti MC (2001) Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104: 569-580
30. Kendall MJ (1999) Possible mechanisms of action in the positive effect of β blockers in heart failure. Heart 82: IV5-IV7
31. Kiehn J (2000) Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A. Trends Cardiovasc Med 10: 205-209
32. Kiehn J, Karle C, Thomas D, Yao X, Brachmann J, Kübler W (1998) HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J Biol Chem 273: 25285-25291
33. Kiehn J, Lacerda AE, Wible BA, Brown AM (1996) Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. Circulation 94: 2572-2579
34. Kiehn J, Thomas D, Karle CA, Schöls W, Kübler W (1999) Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn-Schmiedeberg's Arch Pharmacol 359: 212-219
35. Kihara H, Terai H, Kihara Y, Kihara T, Takahashi H, Kosuda A, Shimomoto M, Fukunishi M, Tanaka T (1997) Pheochromocytoma of the left retroperitoneal paraganglion associated with torsade de pointes: a case report. J Cardiol 30: 37-44
36. 1-adrenergic system and arrhythmias in ischaemic heart disease. Eur Heart J 12 (suppl F): 88-98
37. Lacerda AE, Kramer J, Shen KZ, Thomas D, Brown AM (2001) Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs. Eur Heart J 3: K23-K30
38. Lei M, Brown HF, Terrar DA (2000) Modulation of delayed rectifier potassium current, IK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol 85: 27-35
39. Lerman BB, Belardinelli L, West GA, Berne RM, DiMarco JP (1986) Adenosinesensitive ventricular tachycardia: evidence suggesting cAMP-mediated triggered activity. Circulation 74: 270-280
40. Lerman BB, Stein KM, Markowitz SM (1996) Adenosine-sensitive ventricular tachycardia: a conceptual approach. J Cardiovasc Electrophysiol 7: 559-569
41. + current by protein kinase C and protein kinase A. Circ Res 83: 995-1002
42. Lown B. Sudden cardiac death: biobehavioral perspective (1987) Circulation 76: I186-I196
43. Magyar J, Iost N, Körtvely A, Banyasz T, Virag L, Szigligeti P, Varro A, Opincariu M, Szecsi J, Papp JG, Nanasi PP (2000) Effects on endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes. Pfügers Arch-Eur J Physiol 441: 144-149
44. Mazur A, Roden DM, Anderson ME (1999) Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. Circulation 100: 2437-2442
45. McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA, Fishman GI (1997) A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature 388: 289-292
46. McNeill AJ, Adgey AA, Wilson C (1992) Recurrent ventricular arrhythmias complicating myocardial infarction in the presence of pheochromocytoma. Am Heart J 67: 97-98
47. 1-adrenergic receptor regulation: basic science and clinical implications. Pharmacol Therapeut 88: 281-309
48. Moss AJ, Zareba W, Hall J, Schwartz PJ, Crampton RS, Benhorin J, Vincent GM, Locati EH, Priori SG, Napolitano C, Medina A, Zhang L, Robinson JL, Timothy K, Towbin JA, Andrews ML (2000) Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome. Circulation 101: 616-623
49. Naccarelli GV, Goldstein RA (1989) Electrophysiology of phosphodiesterase inhibitors. Am J Cardiol 63: 35A-40A
50. Napolitano C, Priori S, Schwartz P (1994) Torsade de pointes. Mechanisms and management. Drugs 47:51-65
51. Nuttall SL, Toescu V, Kendall MJ (1999) The incidence of sudden death in postmyocardial infarction beta blocker trials. J Clin Pharm Ther 24: 237-239
52. Packer M (1989) Effect of phosphodiesterase inhibitors on survival of patients with congestive heart failure. Am J Cardiol 63: 41A-45A
53. 1-adrenergic receptors: new insights and directions. J Pharmacol Exp Ther 298:403-410
54. Priori S, Aliot E, Blomstrom-Lundqvist C, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, Camm AJ, Cappato R, Cobbe SM, DiMario C, Maron BJ, McKenna WJ, Pedersen AK, Ravens U, Schwartz PJ, Trusz-Gluza M, Vardas P, Wellens HJ, Zipes DP (2001) Task force on sudden cardiac death of the European Society of Cardiology. Eur Heart J 22: 1374-1450
55. Priori S, Napolitano C, Paganini V, Cantu F, Schwartz PJ (1997) Molecular biology of the long QT syndrome: impact on management Pacing Clin Electrophysiol 20: 2052-2057
56. Poldermans D, Fioretti PM, Boersma E, Forster T, van Urk H, Cornel JH, Arnese M, Roelandt RT (1994) Safety of dobutamine-atropine stress echocardiography in patients with suspected or proven coronary artery disease. Am J Cardiol 73: 456-459
57. Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, Vincent M (1996) Multiple mechanisms in the long QT syndrome. Current knowledge, gaps, and future directions. The SADS foundation task force on LQTS. Circulation 94:1996-2012
58. Ron D, Kazanietz MG (1999) New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13: 1658-1676
59. +-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A 93: 2208-2212
60. Sanguinetti MC, Jiang C, Curran ME, Keating MT (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81: 299-307
61. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PK (1991) Isoproterenol antagonizes prolongation of refractory period by class III antiarrhythmic agent in guinea pig myocytes. Circ Res 69: 77-84
62. Schäfer R, Wolfsen I, Behrens S, Weinsberg F, Bauer CK, Schwarz JR (1999) The erg-like potassium current in rat lactotrophs. J Physiol 518: 401-416
63. Schaffer P, Pelzmann B, Bernhart E, Lang P, Machler H, Rigler B, Koidl B (1999) Repolarizing currents in ventricular myocytes from young patients with tetralogy of Fallot. Cardiovasc Res 43: 332-343
64. Kr currents in a case report of drug-induced cardiac arrhythmia. Br J Pharmacol 137: 892-900
65. + currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol 532: 143-163
66. Schwartz PJ, Priori SG, Napolitano C (2000) The long QT syndrome. In: Cardiac electrophysiology: from cell to bedside (3rd ed.), edited by Zipes DP and Jalife J. Philadelphia, USA: Saunders, 597-615
67. Shimizu K, Miura Y, Meguro Y, Noshiro T, Ohzeki T, Kusakari T, Akama H, Watanabe T, Hunma H, Imai Y (1992) QT prolongation with torsade de pointes in pheochromocytoma. Am Heart J 124: 235-239
68. + current. FEBS Lett 495: 154-158
69. + channel. Open-channel block by methanesulfonanilides. Circ Res 78:499-503
70. Sugita S, Baxter DA, Byrne JH (1997) Modulation of a cAMP/protein kinase A cascade by protein kinase C in sensory neurons of Aphysia. J Neurosci 17: 7237-7244
71. Sun ZH, Swan H, Viitasalo M, Toivonen L (1998) Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome. J Am Coll Cardiol 31: 1400-1405
72. Teerlink JR, Massie BM (1999) Beta-adrenergic blocker mortality trials in congestive heart failure. Am J Cardiol 84: 94R-102R
73. Thomas D, Gut B, Wendt-Nordahl G, Kiehn J (2002) The antidepressant drug fluoxetine is an inhibitor of human ethera-go-go-related gene (HERG) potassium channels. J Pharmacol Exp Ther 300: 543-548
74. Thomas D, Kiehn J, Katus HA, Karle CA (2003) Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): Molecular mechanisms and restoration of intracellular protein processing. Cardiovasc Res 60: 239-245
75. Thomas D, Wendt-Nordahl G, Röckl K, Ficker E, Brown AM, Kiehn J (2001) High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J Pharmacol Exp Ther 297: 753-76
76. Thomas D, Zhang W, Karle CA, Kathofer S, Schols W, Kubler W, Kiehn J (1999) Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J Biol Chem 274: 27457-27462
77. Thomas D, Zhang W, Wu K, Wimmer AB, Gut B, Wendt-Nordahl G, Kathofer S, Kreye VAW, Katus HA, Schoels W, Kiehn J, Karle CA (2003) Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein. Cardiovasc Res 59: 14-26
78. + current of guinea pig ventricular cells through activation of protein kinase C. Circ Res 71: 1441-1446
79. Varriale P, Ramaprasad S (1995) Septic cardiomyopathy as a cause of long QT syndrome. J Electrocardiol 28: 327-329
80. Viskin S (1999) Long QT syndromes and torsade de pointes. Lancet 354: 1625-1633
81. Walsh KB, Kass RS (1988) Regulation of a heart potassium channel by protein kinase A and C. Science 242: 67-69
82. Wang Z, Fermini B, Nattel S (1994) Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res 28: 1540-1546
83. Warmke JW, Ganetzky B (1994) A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A 91: 3438-3442
84. Weerapura M, Nattel S, Chartier D, Caballero R, Hebert TE (2002) A comparison of currents carried by HERG, with and without coexpression of MiRP1,and the native rapid delayed rectifier current. Is MiRP1 the missing link? J Physiol 540: 15-27
85. Wei Z, Thomas D, Karle CA, Kathofer S, Schenkel J, Kreye VA, Ficker E, Wible BA, Kiehn J (2002) Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line. Chin Med J 115:668-676
86. Yang SL, Hsu C, Lue SI, Hsu HK, Liu MS (1997) Protein kinase A activity is increased in rat heart during late hypodynamic phase of sepsis. Shock 8: 68-72