Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A

Journal of Biological Chemistry

Volumn 274, Issue 39, 1999, Pages 27457-27462

  Thomas, Dierk ^a   Zhang, Wei ^a   Karle, Christoph A ^a   Kathöfer, Sven ^a   Schöls, Wolfgang ^a   Kübler, Wolfgang ^a   Kiehn, Johann ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP PHOSPHODIESTERASE; FORSKOLIN; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; GENE MUTATION; HEART REPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; REGULATORY MECHANISM; XENOPUS;

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATION TRANSPORT PROTEINS; CELL MEMBRANE; CONSENSUS SEQUENCE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; FORSKOLIN; HUMANS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHOSPHORYLATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN FOLDING; RECOMBINANT PROTEINS; SEQUENCE DELETION; TRANS-ACTIVATORS; XENOPUS LAEVIS;

EID: 0033600758     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.39.27457     Document Type: Article

References (28)

1. Carmeliet, E. (1993) Eur. Heart J. 14, Suppl. H, 3-13
2. Warmke, J. E., and Ganetzky, B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3438-3442
3. Sanguinetti, M. C., Changan, J., Curran, M. E., and Keating, M. T. (1995) Cell 81, 1-20
4. Trudeau, M. C., Warmke, J. W., Ganetzky, B., and Robertson, G. A. (1995) Science 269, 92-95
5. Kiehn, J., Lacerda, A. E., Wible, B., and Brown, A. M. (1996) Circulation 94, 2572-2579
6. Spector, P. S., Curran, M. E., Keating, M. T., and Sanguinetti, M. C. (1996) Circ. Res. 78, 499-503
7. Kiehn, J., Thomas, D., Karle, C. A., Schöls, W., and Kubler, W. (1999) Naunyn-Schmiedeberg's Arch. Pharmacol. 359, 212-219
8. Sanguinetti, M. C., Curran, M. E., Spector, P. S., and Keating, M. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2208-2212
9. Roden, D. M., Lazzara, R., Rosen, M., Schwartz, P. J., Towbin, J., and Vincent, G. M. (1996) Circulation 94, 1996-2012
10. Walsh, K. B., and Kass, R. S. (1988) Science 242, 67-69
11. Seamon, K. B., Padgett, W., and Daly, J. W. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 3363-3367
12. Beavo, J. A. (1998) Adv. Second Messenger Phosphoprotein Res. 22, 1-38
13. Kiehn, J., Karle C., Thomas D., Yao X., Brachmann J., and Kubler, W. (1998) J. Biol. Chem. 273, 25285-25291
14. Sanguinetti, M. C., and Jurkiewicz, N. K. (1990) J. Gen. Physiol. 98, 195-215
15. Palma, E., Yu, Z., Fishman, G. I., and McDonald, T. V. (1998) Circulation 98, Suppl. I, 57
16. Darbon, J. M., Valette, A., and Bayard, F. (1986) Biochem. Pharmacol. 35, 2683-2686
17. Sun, Z. H., Swan, H., Viitasalo, M., and Toivonen, L. (1998) J. Am. Coll. Cardiol. 31, 1400-1405
18. Kang, J. X., and Leaf, A. (1995) Biochem. Biophys. Res. Commun. 208, 629-636
19. Lerman, B. B., Belardinelli, L., West, G. A., Berne, R. M., and DiMarco, J. P. (1986) Circulation 74, 270-280
20. Hsu, C., Yang, S. L., Hsu, S. P., Hsu, H. K., and Liu, M. S. (1997) J. Surg. Res. 71, 161-165
21. Bender, J. S. (1996) Am. Surg. 62, 73-75
22. Yang, S. L., Hsu, C., Lue, S. I., Hsu, H. K., and Liu, M. S. (1997) Shock 8, 68-72
23. Varriale, P., and Ramaprasad, S. (1995) J. Electrocardiol. 28, 327-329
24. Saman, S., Coetzee, W. A., and Opie, L. H. (1988) J. Mol. Cell. Cardiol. 20, 91-95
25. Priori, S. G., Napolitano, C., Paganini, V., Cantu, F., and Schwartz, P. J. (1997) PACE 20, 2052-2057
26. Zhou, J. T., Zheng, L. R., and Liu, W. Y. (1992) PACE 15, 2164-2168
27. Naccarelli, G. V., and Goldstein, R. A. (1989) Am. J. Cardiol. 63, 35A-40A
28. Packer, M. (1989) Am. J. Cardiol. 63, 41A-45A