Systemic administration of calmodulin antagonist W-7 or protein kinase a inhibitor H-8 prevents torsade de pointes in rabbits

Circulation

Volumn 100, Issue 24, 1999, Pages 2437-2442

  Mazur, Alexander ^a,b   Roden, Dan M ^a   Anderson, Mark E ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calmodulin kinase; Long QT syndrome; Torsade de pointes

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL STIMULATING AGENT; CALMODULIN INHIBITOR; CLOFILIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; METHOXAMINE; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BLOOD PRESSURE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; HEART RATE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RABBIT; TORSADE DES POINTES;

EID: 0032764067     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.24.2437     Document Type: Article

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